Turkiye Klinikleri Journal of Internal Medical Sciences

Kortikosteroidler (Glukokortikoidler ve Mineralokortikoidler)
CORTICOSTEROIDS (GLUCOCORTICOIDS AND MINERALOCORTICOIDS)
Zeynep Sevim ERCAN,aBerna MERCAN ALIŞIRa
aTıbbi Farmakoloji AD, Gazi Üniversitesi, Tıp Fakültesi, ANKARA
Turkiye Klinikleri J Int Med Sci 2005;1(35):73-7
Article Language: TR
ÖZET
ACTH uyarısı ile kortizol ve diğer doğal glukokortikoidler, adrenal korteksin zona fasiculata ve zona reticularis tabakalarından, mineralokortikoidler ise zona glomeruloza tabakasında kolesterolden sentez edilmektedir. Glukokortikoidler protein olan reseptörler aracılığıyla etkilerini gösterirler. Glukokortikoidler organizmada birçok hücrenin fonksiyonlarını etkilerler ve kullanılan doza bağlı olarak anabolik ve katabolik etki yaparlar. Glukokortikoidlerin tedavide önem taşıyan antiinflamatuar ve immünsupresif etkileri vardır. Birçok hastalığın tedavisinde kullanılmalarına rağmen önemli yan etkileri bulunmaktadır. Adrenokortikal hormon sentezini inhibe eden veya reseptörlerini antagonize eden Metirapon, Aminoglutetimid, Mifepriston, Spironolakton gibi birçok ilaç tedavide kullanılmaktadır.

Anahtar Kelimeler: Glukokortikoid, mineralokortikoid, kortikosteroid
ABSTRACT
Cortisol and another glucocorticoids are synthesized in zona fasiculata and zona reticularis layers while mineralocorticoids are synthesized from cholesterol in zona glomerulosa layer by the stimulation of ACTH in the adrenal cortex. Effects of glucocorticoids are mediated by spesific receptors which are protein. They influence most functions of the cell and produce either anabolic or catabolic effect which depends on the dose used. Glucocorticoids have antiinflammatory and immunosupressive effects which are used for therapeutic purposes. Although they are widely used for the treatment of many diseases, they have serious side effects. Drugs which inhibit the synthesis of adrenocorticol hormones or antagonize receptors such as Metyrapone, Aminoglutethimide, Mifepriston, Spironolactone are used in the treatment of various diseases.

Keywords: Glucocorticoid, mineralocorticoid, corticosteroid

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