Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Investigation of the Effect of Parathyroid Hormone on Corneal Clarity
Paratiroid Hormonun Kornea Saydamlığı Üzerine Etkisinin İncelenmesi
Ali Mert KOÇERa, Mehmet Ali ŞEKEROĞLUa, Çağatay Emir ÖNDERb, Şerife Mehlika KUŞKONMAZb
aClinic of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, TURKEY
bClinic of Endocrinology, Ankara Training and Research Hospital, Ankara, TURKEY
Turkiye Klinikleri J Ophthalmol. 2021;30(2):107-14
doi: 10.5336/ophthal.2020-79038
Article Language: EN
Full Text
ABSTRACT
 Objective: To evaluate the corneal clarity of the patients with surgically induced hypoparathyroidism (SIH) and compare these results with those of age-matched healthy control subjects. Material and Methods: Fourty six female patients with SIH and 36 age-matched healthy female subjects were enrolled in this prospective study. In order to evaluate the corneal clarity of the patients, corneal densitometry was measured with densitometry software of Scheimpflug corneal topography (Pentacam® HR, Wetzlar, Germany). For densitometry analysis, the 12-mm diameter area of the cornea was subdivided into four concentric radial zones (0 to 2, 2 to 6, 6 to 10, 10 to 12 mm) and also into anterior, central, and posterior layers based on corneal depth. Corneal densitometry measurements were examined, and only the data from the right eyes of the participants were used for statistical analysis. Results: The corneal densitometry measurements of the SIH and control group were similar for all concentric radial zones and corneal depths except the central 0-2 mm (p=0.011), posterior 0-2 mm (p=0.003), posterior 2-6 mm (p=0.011) and total thickness 0-2 mm (p=0.028), of all were statistically significantly lower in SIH group. There was a statistically significant positive correlation between the posterior 10-12 mm corneal densitometry and serum parathyroid hormone levels in the SIH group (p=0.024; r=0.321). Conclusion: This study shows that the corneal clarity of the patients with SIH subjects under the sufficient postoperative treatment was similar when compared to the healthy control.

Keywords: Calcium; corneal densitometry; hypoparathyroidism
ÖZET
 Amaç: Bu çalışmada, cerrahi olarak indüklenen hipoparatiroidizmi olan hastaların kornea saydamlığını değerlendirmek ve bu sonuçları, yaş uyumlu sağlıklı kontrol grubuyla karşılaştırmak amaçlanmıştır. Gereç ve Yöntemler: Prospektif olarak düzenlenen bu çalışmaya, cerrahi olarak indüklenen hipoparatiroidizmi olan 46 kadın hasta ile yaş uyumlu 36 sağlıklı kadın gönüllü dâhil edildi. Hastaların kornea saydamlığı, Scheimpflug kornea topografisinin (Pentacam® HR, Wetzlar, Almanya) kornea dansitometrisi özelliği kullanılarak belirlendi. Dansitometri analizi için 12 mm'lik kornea alanı 4 eş merkezli radyal bölgeye (0-2, 2-6, 6-10, 10-12 mm) ve kornea kalınlığına göre anterior, santral ve posterior katmanlara ayrıldı. Kornea dansitometri ölçümleri incelendi ve istatistiksel analiz için katılımcıların sadece sağ gözlerinden alınan veriler kullanıldı. Bulgular: Cerrahi olarak indüklenen hipoparatiroidizm grubunda istatistiksel olarak anlamlı düşük saptanan santral 0-2 mm (p=0,011), posterior 0-2 mm (p=0,003), posterior 2-6 mm (p=0,011) korneal dansitometri ve toplam korneal kalınlık 0-2 mm (p=0,028) değerleri dışındaki diğer ölçümler, kontrol grubu ile benzerdi. Hipoparatroidizm grubunda 10-12 mm korneal dansitometri değeri ile serum paratiroid hormon düzeyi arasında istatistiksel olarak anlamlı pozitif korelasyon saptandı (p=0,024; r=0,321). Sonuç: Bu çalışma, cerrahi olarak indüklenen hipoparatiroidizmi olan hastaların kornea saydamlığının, yeterli postoperatif tedavi altında sağlıklı kontroller ile benzer olduğunu göstermektedir.

Anahtar Kelimeler: Kalsiyum; korneal dansitometri; hipoparatiroidizm
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