Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
Demographic and Histopathological Features of Oral Mucosa Lesions in Kırşehir Region: A Retrospective Cross-Sectional Study
Kırşehir Yöresinde Oral Mukoza Lezyonlarının Demografik ve Histopatolojik Özellikleri: Retrospektif Kesitsel Bir Çalışma
Emine Müge ACARa, Asuman KİLİTCİb
aClinic of Dermatology, VM Medical Park Keçiören Hospital, Ankara, Türkiye
bDepartment of Pathology, Düzce University Faculty of Medicine, Düzce, Türkiye
Turkiye Klinikleri J Dermatol. 2022;32(2):89-96
doi: 10.5336/dermato.2021-87149
Article Language: EN
Full Text
ABSTRACT
 Objective: The aim of this study was to evaluate the histopathological findings of the excised lesions from oral mucosa and determine the type and frequency of oral mucosa diseases in Kırşehir region. Material and Methods: The histopathology results of 237 patients with oral mucosa lesions who administered to Kırşehir Training and Research Hospital Dermatology Outpatient Clinic and underwent incisional or excisional biopsy between December 2014 and July 2018 were retrospectively evaluated. The demographic characteristics of the patients, disease duration, localisation and frequency of the lesions, the frequency of benign and malignant lesions were recorded. Results: Ninety three (39.2%) male and 144 (60.8%) female patients were recruited in our study. The mean age of the patients was 44.33±1.21 years. A total of 237 oral mucosa lesions were detected. The most common benign lesions were intradermal nevi (n=56, 23.6%) followed by inflammatory granulation tissue (n=25, 10.5%), fibromas (n=26, 11%), mucocele (n=21, 8.9%), pyogenic granuloma (n=16, 6.7%), irritation fibromas (n=14, 5.9%), squamous papilloma (n=8, 3.4%), verruca vulgaris (n=6, 2.5%), lichen planus (n=6, 2.5%), hemangiomas (n=5, 2.1%). The most common malignant lesions were squamous cell carcinoma (n=9, 3.8%) and basal cell carcinoma (n=7, 2.9%), followed by lymphoma (n=1, 0.4%) and basosquamous cell carcinoma (n=1, 0.4%). Conclusion: In our study, the vast majority (92.8%) of the lesions detected in oral mucosa were benign lesions while malignant lesions constituted a small proportion. Gaining knowledge about the distribution of oral mucosal diseases may contribute to prevention and treatment of these diseases.

Keywords: Oral mucosa; lesion; demographic; biopsy; histopathology; retrospective
ÖZET
 Amaç: Bu çalışmanın amacı, Kırşehir yöresinde oral mukozadan eksize edilen lezyonların histopatolojik bulgularının değerlendirilerek oral mukoza hastalıklarının tipi ve sıklığının saptanmasıdır. Gereç ve Yöntemler: 2014 Aralık-Temmuz 2018 arasında Kırşehir Eğitim ve Araştırma Hastanesi dermatoloji polikliniğine oral mukoza lezyonları nedeniyle başvurup insizyonel ya da eksizyonel biyopsi işlemi uygulanan 237 hastanın lezyonlarının histopatoloji sonuçları retrospektif olarak değerlendirildi. Hastaların demografik özellikleri, hastalık süreleri, lezyonların lokalizasyonları, görülme sıklığı, benign ve malign lezyon sıklığı kaydedildi. Bulgular: Çalışmaya 93 (%39,2) erkek, 144 (%60,8) kadın hasta dâhil edildi. Hastaların yaş ortalaması 44,33±1,21 olarak saptandı. Tüm hastalarda toplam 237 oral mukoza lezyonu saptandı. En sık görülen benign lezyonlar intradermal nevüsler (n=56, %23,6) idi. Bunları sırasıyla inflamatuar granülasyon dokusu (n=25, %10,5), fibromlar (n=26, %11), mukosel (n=21, %8,9), piyojenik granüloma (n=16, %6,7), irritasyon fibromu (n=14, %5,9), skuamöz papillom (n=8, %3,4), verruka vulgaris (n=6, %2,5), liken planus (n=6, %2,5), hemanjiyom (n=5, %2,1) takip ediyordu. En sık görülen malign lezyonlar skuamöz hücreli karsinom (n=9, 3.8%) ve bazal hücreli karsinom (n=7, %2,9) olarak saptandı. Bunları lenfoma (n=1, %0,4) ve bazoskuamöz hücreli karsinom (n=1, %0,4) izlemekteydi. Sonuç: Çalışmada, oral mukozada saptanan lezyonların büyük çoğunluğu benign lezyonlardı (%92,8). Malign lezyonlar lezyonların az bir kısmını oluşturmaktaydı. Oral mukoza hastalıklarının dağılımıyla ilgili bilgi edinilmesi bu hastalıkların önlenmesi ve tedavisine katkı sağlayabilecektir.

Anahtar Kelimeler: Oral mukoza; lezyon; demografik; biyopsi; histopatoloji; retrospektif
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