Journal of Traditional Medical Complementary Therapies

.: ORIGINAL RESEARCH
Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials
Akupunkturun, Obez Kadınlardaki Kolesterol, Antioksidan ve Oksidan Parametreler Üzerine Etkileri: Klinik Deneyler
Şebnem Setenay MİTa, Çınar SEVERCANb, Ersel GEÇİOĞLUa, Ayşe Banu ÇAYCI SİVRİc, Canan YILMAZc, Funda GÜÇELc, Cemal ÇEVİKd
aGazi University Faculty of Medicine, Acupuncture and Complementary Medicine Center, Ankara, Türkiye
bDepartment of Biochemistry, Zonguldak Bülent Ecevit University Faculty of Pharmacy, Zonguldak, Türkiye
cDepartment of Medical Biochemistry, Gazi University Medicine Faculty, Ankara, Türkiye
dDepartment of Medical Biochemistry, Lokman Hekim University Medicine Faculty, Ankara, Türkiye
J Tradit Complem Med. 2022;5(2):96-105
doi: 10.5336/jtracom.2021-87383
Article Language: EN
Full Text
ABSTRACT
 Objective: Obesity has a profound adverse impact on health care systems. Acupuncture has been shown to have beneficial effects on obesity. The aim of this study is to investigate the effects of acupuncture on serum oxidative stress parameters in obese women. Material and Methods: During the study, 20 obese patients had acupuncture treatment, and as a control group, 20 obese patients had sham acupuncture treatment. Serum samples were taken from each patient before the first session and at the end of the 10th session and serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol, malondialdehyde (MDA), advanced oxidation protein products (AOPP), the serum activity of superoxide dismutase enzyme (SOD) and glutathione peroxidase enzyme (GPx) were measured. Results: Changes in the serum levels of TG, HDL, MDA, AOPP and activity of SOD after the treatment compared to before the treatment in both acupuncture and sham acupuncture treated groups were found insignificant (p>0.05). On the other hand, the TC and LDL levels were observed to decrease significantly in comparison to the before-treatment values in both the acupuncture and sham acupuncture groups (p<0.05). In addition to this, the GPx activity significantly increased only as a result of the acupuncture treatment (p<0.05). Conclusion: The results of our study indicated that acupuncture treatment may be effective in reducing cholesterol levels and increasing the activity of antioxidant enzymes.

Keywords: Acupuncture; obesity; cholesterol; oxidative stress; antioxidants
ÖZET
 Amaç: Obezite, bireyin sağlığı üzerinde olumsuz etkiye sahiptir. Akupunktur tedavisinin obezite üzerinde olumlu etkileri olduğu gösterilmiştir. Bu çalışmanın amacı, obez kadınlarda akupunkturun serum oksidatif stres parametreleri üzerindeki etkilerini araştırmaktır. Gereç ve Yöntemler: Çalışma süresince 20 obez bireye akupunktur tedavisi, kontrol grubu olarak 20 obez bireye sham akupunktur tedavisi uygulanmıştır. Her hastadan ilk seans öncesi ve 10. seans sonunda serum örnekleri alınarak toplam kolesterol [total cholesterol (TC)], trigliseridler (TG), yüksek yoğunluklu lipoprotein [high-density lipoprotein (HDL)] kolesterol ve düşük yoğunluklu lipoprotein [low-density lipoprotein (LDL)] kolesterol serum seviyeleri alınmıştır. Alınan serum örnekleri üzerinden kolesterol, malondialdehit (MDA), ileri oksidasyon protein ürünleri [advanced oxidation protein products (AOPP)], süperoksit dismutaz enzimi (SOD) ve glutatyon peroksidaz enzimi (GPx) serum aktivitesi ölçülmüştür. Bulgular: Hem akupunktur hem de sham akupunktur uygulanan gruplarda tedavi öncesi ile karşılaştırıldığında, tedavi sonrası serum TG, HDL, MDA, AOPP ve SOD aktivitesindeki farkın anlamlılığı bulunamamıştır (p>0,05). Buna rağmen hem akupunktur hem de sham akupunktur gruplarında TC ve LDL düzeylerinin tedavi öncesi değerlere göre anlamlı derecede düştüğü gözlenmiştir (p<0,05). Ek olarak, GPx aktivitesi sadece akupunktur tedavisi sonucunda anlamlı olarak artmıştır (p<0,05). Sonuç: Çalışmamızın sonuçları, akupunktur tedavisinin kolesterol düzeylerini düşürmede ve antioksidan enzimlerin aktivitesini artırmada etkili olabileceğini göstermiştir.

Anahtar Kelimeler: Akupunktur; obezite; kolesterol; oksidatif stres; antioksidanlar
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