Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
Effect of Using Rotational and Reciprocating Single File Systems with Different Tapered Coronal Flaring Instruments on Dentinal Crack Formation: An In Vitro Study
Farklı Taperlı Koronal Genişletme Enstrümanlarının Rotasyonel ve Resiprokal Tek Eğe Sistemlerindeki Dentin Çatlağı Oluşumuna Etkisinin İncelenmesi: İn Vitro Çalışma
Esin ÖZLEKa, Gizem KADIa, Furkan EVRENDİLEKa
aDepartment of Endodontics, Van Yüzüncü Yıl University Faculty of Dentistry, Van, TURKIYE
Turkiye Klinikleri J Dental Sci. 2022;28(1):105-12
doi: 10.5336/dentalsci.2021-82764
Article Language: EN
Full Text
ABSTRACT
 Objective: The purpose of this study was to evaluate the effect of using single-file with different tapered coronal flaring files on dentinal crack. Material and Methods: Human extracted mandibular premolars (n=128) were selected and divided into four groups (n=32) based on the coronal flaring instruments; Group 1, One Flare; Group 2, Endoflare; Group 3, Gates Glidden Drills; Group 4, Control Group. Specimens divided into four subgroups based on the single file system (n=8): Subgroup A, HyFlex EDM: Subgroup B, Reciproc Blue: Subgroup C, One Shape: Subgroup D, WaveOne Gold. All roots were then sectioned at 3, 6, and 9 mm from the apex. The sections were inspected under a stereo-microscope at 2.5X and 5X to determine the presence of microcracks. The data were analyzed using the chi-square test (p=0.05). Results: There was no statistically significant difference between the distributions of dentinal cracks caused by the use of single-file systems with different coronal flaring files (p>0.05). There was no statistically significant difference between the distributions of dentinal cracks according to single file systems (p>0.05). There was also no statistically significant difference between the distributions of dentinal cracks according to coronal flaring files (p>0.05). Conclusion: The use of coronal flaring instruments combinations with single file systems reduced the observation of dentin cracks. One Flare files caused less dentinal cracks than the other instruments test.

Keywords: Coronal flaring; microcracks; single-file systems; One Flare; WaveOne Gold
ÖZET
 Amaç: Bu çalışmanın amacı, farklı taperlı koronal genişletme enstrümanlarının rotasyonel ve resiprokal tek eğe sistemleri ile kullanımının dentin çatlağı üzerine etkisini değerlendirmektir. Gereç ve Yöntemler: Çalışmada 128 adet tek köklü mandibular premolar diş koronal genişletme için kullanılacak enstrümanlara göre 4 ana gruba (n=32) ayrılmıştır: Grup 1, One Flare; Grup 2, Endoflare; Grup 3, Gates Glidden drills; Grup 4, Kontrol Grup. Daha sonra örnekler kök kanal şekillendirilmesinde kullanılacak tek eğe sistemlerine göre 4 alt gruba (n=8) ayrılmıştır: Alt Grup A, HyFlex EDM; Alt Grup B, Reciproc Blue; Alt Grup C, One Shape; Alt Grup D, WaveOne Gold. Tüm örneklerden kök ucundan 3, 6 ve 9 mm uzaklıklarda kesitler alınmıştır. Kesitler, mikro çatlakların varlığını belirlemek için bir stereo-mikroskop altında 2,5X ve 5X'de incelenmiştir. Veriler ki-kare testi kullanılarak analiz edilmiştir (p=0,05). Bulgular: Tek eğe sistemlerinin farklı koronal flaring eğeler ile kullanmasıyla oluşan dentin çatlaklarının dağılımları arasında istatistiksel olarak anlamlı bir fark yoktur (p>0,05). Tek eğe sistemlerine göre dentin çatlaklarının dağılımları arasında da istatistiksel olarak anlamlı bir fark bulunmamıştır (p>0,05). Bununla birlikte, koronal genişletme eğelerine göre dentin çatlaklarının dağılımları arasında istatistiksel olarak anlamlı bir fark yoktur (p>0,05). Sonuç: Tek eğe sistemlerinin koronal flaring estrümanları ile beraber kullanımının dentin çatlaklarının gözlemlenmesini azaltmıştır. One Flare eğeler, diğer koronal genişletme enstrümanlarına göre daha az dentin çatlağına neden olmuştur.

Anahtar Kelimeler: Koronal genişletme; microçatlak; tek eğe sistemleri; One Flare; WaveOne Gold
REFERENCES:
  1. Ehrhardt IC, Zuolo ML, Cunha RS, De Martin AS, Kherlakian D, Carvalho MC, et al. Assessment of the separation incidence of mtwo files used with preflaring: prospective clinical study. J Endod. 2012;38(8):1078-81. [Crossref]  [PubMed] 
  2. Ataya M, Ha JH, Kwak SW, Abu-Tahun IH, El Abed R, Kim HC. Mechanical Properties of Orifice Preflaring Nickel-titanium Rotary Instrument Heat Treated Using T-Wire Technology. J Endod. 2018;44(12):1867-71. [Crossref]  [PubMed] 
  3. Ha JH, Kim SK, Kwak SW, El Abed R, Bae YC, Kim HC. Debris extrusion by glide-path establishing endodontic instruments with different geometries. J Dent Sci. 2016;11(2):136-40. [Crossref]  [PubMed]  [PMC] 
  4. Arslan H, Karataş E, Capar ID, Ozsu D, Doğanay E. Effect of ProTaper Universal, Endoflare, Revo-S, HyFlex coronal flaring instruments, and Gates Glidden drills on crack formation. J Endod. 2014;40(10):1681-3. [Crossref]  [PubMed] 
  5. De-Deus G, Brandão MC, Barino B, Di Giorgi K, Fidel RA, Luna AS. Assessment of apically extruded debris produced by the single-file ProTaper F2 technique under reciprocating movement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(3):390-4. [Crossref]  [PubMed] 
  6. Pedullà E, Genovesi F, Rapisarda S, La Rosa GR, Grande NM, Plotino G, et al. Effects of 6 Single-File Systems on Dentinal Crack Formation. J Endod. 2017;43(3):456-61. [Crossref]  [PubMed] 
  7. Özyürek T, Yılmaz K, Uslu G. Shaping Ability of Reciproc, WaveOne GOLD, and HyFlex EDM Single-file Systems in Simulated S-shaped Canals. J Endod. 2017;43(5):805-9. [Crossref]  [PubMed] 
  8. Silva EJ, Carapiá MF, Lopes RM, Belladonna FG, Senna PM, Souza EM, et al. Comparison of apically extruded debris after large apical preparations by full-sequence rotary and single-file reciprocating systems. Int Endod J. 2016;49(7):700-5. [Crossref]  [PubMed] 
  9. Borges ÁH, Damião MS, Pereira TM, Filho GS, Miranda-Pedro FL, Luiz de Oliveira da Rosa W, et al. Influence of Cervical Preflaring on the Incidence of Root Dentin Defects. J Endod. 2018;44(2):286-91. [Crossref]  [PubMed] 
  10. Liu R, Kaiwar A, Shemesh H, Wesselink PR, Hou B, Wu MK. Incidence of apical root cracks and apical dentinal detachments after canal preparation with hand and rotary files at different instrumentation lengths. J Endod. 2013;39(1):129-32. [Crossref]  [PubMed] 
  11. Shemesh H, Bier CA, Wu MK, Tanomaru-Filho M, Wesselink PR. The effects of canal preparation and filling on the incidence of dentinal defects. Int Endod J. 2009;42(3):208-13. [Crossref]  [PubMed] 
  12. Bier CA, Shemesh H, Tanomaru-Filho M, Wesselink PR, Wu MK. The ability of different nickel-titanium rotary instruments to induce dentinal damage during canal preparation. J Endod. 2009;35(2):236-8. [Crossref]  [PubMed] 
  13. Liu R, Hou BX, Wesselink PR, Wu MK, Shemesh H. The incidence of root microcracks caused by 3 different single-file systems versus the ProTaper system. J Endod. 2013;39(8):1054-6. [Crossref]  [PubMed] 
  14. Özyürek T. Cyclic Fatigue Resistance of Reciproc, WaveOne, and WaveOne Gold Nickel-Titanium Instruments. J Endod. 2016;42(10):1536-9. [Crossref]  [PubMed] 
  15. Serafin M, De Biasi M, Franco V, Angerame D. In vitro comparison of cyclic fatigue resistance of two rotary single-file endodontic systems: OneCurve versus OneShape. Odontology. 2019;107(2):196-201. [Crossref]  [PubMed] 
  16. Pirani C, Iacono F, Generali L, Sassatelli P, Nucci C, Lusvarghi L, et al. HyFlex EDM: superficial features, metallurgical analysis and fatigue resistance of innovative electro discharge machined NiTi rotary instruments. Int Endod J. 2016;49(5):483-93. [Crossref]  [PubMed] 
  17. Yoldas O, Yilmaz S, Atakan G, Kuden C, Kasan Z. Dentinal microcrack formation during root canal preparations by different NiTi rotary instruments and the self-adjusting file. J Endod. 2012;38(2):232-5. [Crossref]  [PubMed] 
  18. Bürklein S, Tsotsis P, Schäfer E. Incidence of dentinal defects after root canal preparation: reciprocating versus rotary instrumentation. J Endod. 2013;39(4):501-4. [Crossref]  [PubMed] 
  19. Kim HC, Lee MH, Yum J, Versluis A, Lee CJ, Kim BM. Potential relationship between design of nickel-titanium rotary instruments and vertical root fracture. J Endod. 2010;36(7):1195-9. [Crossref]  [PubMed] 
  20. Shen Y, Tra C, Hieawy A, Wang Z, Haapasalo M. Effect of Torsional and Fatigue Preloading on HyFlex EDM Files. J Endod. 2018;44(4):643-7. [Crossref]  [PubMed] 
  21. Dane A, Capar ID, Arslan H, Akçay M, Uysal B. Effect of different torque settings on crack formation in root dentin. J Endod. 2016;42(2):304-6. [Crossref]  [PubMed] 
  22. Karataş E, Gündüz HA, Kırıcı DÖ, Arslan H, Topçu MÇ, Yeter KY. Dentinal crack formation during root canal preparations by the twisted file adaptive, ProTaper Next, ProTaper Universal, and WaveOne instruments. J Endod. 2015;41(2):261-4. [Crossref]  [PubMed] 
  23. Shantiaee Y, Dianat O, Mosayebi G, Namdari M, Tordik P. Effect of root canal preparation techniques on crack formation in root dentin. J Endod. 2019;45(4):447-52. [Crossref]  [PubMed] 
  24. De-Deus G, Belladonna FG, Silva EJNL, Souza EM, Carvalhal JCA, Perez R, et al. Micro-CT assessment of dentinal micro-cracks after root canal filling procedures. Int Endod J. 2017;50(9):895-901. [Crossref]  [PubMed] 
  25. Fráter M, Jakab A, Braunitzer G, Tóth Z, Nagy K. The potential effect of instrumentation with different nickel titanium rotary systems on dentinal crack formation-An in vitro study. PLoS One. 2020;15(9):e0238790. [Crossref]  [PubMed]  [PMC] 
  26. Ceyhanli KT, Erdilek N, Tatar I, Celik D. Comparison of ProTaper, RaCe and Safesider instruments in the induction of dentinal microcracks: a micro-CT study. Int Endod J. 2016;49(7):684-9. [Crossref]  [PubMed] 
  27. Zuolo ML, De-Deus G, Belladonna FG, Silva EJ, Lopes RT, Souza EM, et al. Micro-computed Tomography Assessment of Dentinal Micro-cracks after Root Canal Preparation with TRUShape and Self-adjusting File Systems. J Endod. 2017;43(4):619-22. [Crossref]  [PubMed] 
  28. Bayram HM, Bayram E, Ocak M, Uygun AD, Celik HH. Effect of protaper gold, self-adjusting file, and XP-endo Shaper instruments on dentinal microcrack formation: A micro-computed tomographic study. J Endod. 2017;43(7):1166-9. [Crossref]  [PubMed] 
  29. Çapar İD, Gök T, Uysal B, Keleş A. Comparison of microcomputed tomography, cone beam tomography, stereomicroscopy, and scanning electron microscopy techniques for detection of microcracks on root dentin and effect of different apical sizes on microcrack formation. Microsc Res Tech. 2019;82(10):1748-55. [Crossref]  [PubMed] 

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