Journal of Traditional Medical Complementary Therapies

.: REVIEW
Antimikrobiyal Olarak Kullanılan Bazı Uçucu Yağların Antiviral Özellikleri ve Aromaterapi Uygulamaları
Antiviral Properties of Some Essential Oils Used as Antimicrobial Agents and Aromatherapy Applications
Aslı YAZICIOĞLUa, Hatice Betül BİNGÖLa
aPlatform Essencia, İstanbul, TÜRKİYE
J Tradit Complem Med. 2021;4(1):98-108
doi: 10.5336/jtracom.2020-75721
Article Language: TR
Full Text
ÖZET
Uçucu yağlar (esansiyel yağlar da denir); aromatik bitkilerin çiçek, yaprak, kök, tohum, kabuk, reçine, odun, ot veya yumru gibi farklı organlarında oluşan ve sekonder metabolitler olarak adlandırılan bileşenlerin, distilasyon (damıtma) veya mekanik presleme (narenciye türleri) yöntemlerine maruz kalarak son ürün hâline getirilmesi ile elde edilirler. Uçucu yağlar başta terpenler (monoterpen, seskiterpen ve nadiren diterpenler), onların oksijenli türevleri ve fenilpropanoitler ve bazen de yağ asitleri olmak üzere çok sayıda bileşenden oluşurlar. Pek çok uçucu yağ ve bu yağlarda bulunan bileşenler, in vitro/in vivo çalışmalar ve klinik araştırmalar ile teyit edilmiş biyoaktiviteye sahip olup; analjezik, antiinflamatuar, antibakteriyel, antifungal, antiviral ve antioksidan etkileri ile bilinirler. Uçucu yağlardan ilaç, kozmetik, veterinerlik, gıda ve tarım gibi pek çok alanda faydalanılmaktadır. Uçucu yağların iyi ve sağlıklı olma hâlini destekleyici, koruyucu ve tedavi amaçlı sistemli ve kontrollü kullanımları aromaterapi olarak adlandırılmaktadır. Söz konusu yağlar asıl olarak solunum yolu ve cilt üzerinden kullanılmakta olup, dâhilen de uygulanabilmektedir. Uçucu yağlardan hazırlanan kapsül, supozituvar, ovül gibi ürünlerin sistemik uygulamalarıyla öne çıkan medikal aromaterapi, fitoterapinin özel bir alanı olarak değerlendirilebilir. Bu derlemede, Türkiye'de yetişen veya yaygın olarak kullanılan aromatik bitkilerden elde edilen uçucu yağların başta HSV-1, HSV-2, influenza, şiddetli akut solunum sendromu ve Orta Doğu solunum sendromu olmak üzere insanlarda enfeksiyona sebep olan virüslere karşı antiviral aktivitelerinin araştırıldığı çalışmalar sunulmuştur. Ayrıca uçucu yağların antiviral etki mekanizması değerlendirilmiş olup, potansiyel uygulamalar üzerine görüş bildirilmiştir.

Anahtar Kelimeler: Uçucu yağlar; terpenler; aromaterapi; tıbbi bitkiler; antiviral ajanlar
ABSTRACT
Essential oils are obtained as final products through exposure to distillation or mechanical pressing (types of citrus) of components called secondary metabolites which are synthesized in different parts of aromatic plants, such as flowers, leaves, roots, seeds, bark, resin, wood, grass, or rhizomes. Essential oils consist of many components, primarily terpenes (monoterpen, sesquiterpene and rarely diterpenes), their oxygenated derivatives, phenylpropanoids and some fatty acids. Many essential oils and components found in these oils have bioactivity confirmed by in vitro/in vivo studies and clinical research and are known for their analgesic, anti-inflammatory, antibacterial, antifungal, antiviral and antioxidant effects. Essential oils are used in many fields such as veterinary medicine, agriculture, food, cosmetics and medicine. Therapeutic use of essential oils that support the well-being and health is named as aromatherapy, and can be applied internally as well as through the respiratory tract and skin. On the other hand, medical aromatherapy, which stands out with the systemic applications of products such as capsules, suppositories, ovules prepared from essential oils, can be considered as a special area of phytotherapy. This review is focused on the antiviral activity of essential oils derived from the medicinal and aromatic plants grown or commonly used in Turkey against viruses that cause infections in humans including HSV-1, HSV-2, influenza virus, severe acute respiratory syndrome and middle east respiratory syndrome. In addition, the antiviral mechanism of essential oils has been evaluated and opinions have been stated on potential applications.

Keywords: Essential oils; terpenes; aromatherapy; aromatic and medicinal plants; antiviral agents
REFERENCES:
  1. Erichsen-Brown C. Use of Plants for the Past 500 years. 1st ed. Aurora: Breezy Creeks Press; 1979.
  2. Guenther E. The essential oils vol. IV. 1st ed. New York: D.Van Nostrand; 1950.
  3. Nakatsu T, Lupo AT, Chinn JW, Kang RKL. Biological activity of essential oils and their constituents. Stud. Nat. Prod. Chem. 2000;21:571-631. [Crossref] 
  4. Breitmaier A. Sesquiterpenes, Diterpenes, Sesterterpenes. Terpenes: Flavors, Fragrances, Pharmaca, Pheromones. 1st ed. Weinheim: WILEY-VCH; 2006. p. 43-86. [Crossref] 
  5. de Rapper S, Van Vuuren SF, Kamatou GP, Viljoen AM, Dagne E. The additive and synergistic antimicrobial effects of select frankincense and myrrh oils--a combination from the pharaonic pharmacopoeia. Lett Appl Microbiol. 2012;54(4):352-8. [Crossref]  [PubMed] 
  6. Koo M. A bibliometric analysis of two decades of aromatherapy research. BMC Res Notes. 2017;10(1):46. [Crossref]  [PubMed]  [PMC] 
  7. Cos P, Vlietinck AJ, Berghe DV, Maes L. Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'. J Ethnopharmacol. 2006;106(3):290-302. [Crossref]  [PubMed] 
  8. Edris AE. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytother Res. 2007;21(4):308-23. [Crossref]  [PubMed] 
  9. Adorjan B, Buchbauer G. Biological properties of essential oils: an updated review. Flavour Frag J. 2010;25(6):407-26. [Crossref] 
  10. Raut JS, Karuppayil SM. A status review on the medicinal properties of essential oils. Ind Crops Prod. 2014;62:250-64. [Crossref] 
  11. Mancianti F, Ebani VV. Special issue: Biological activity of essential oils. Molecules. 2020;25(3):678-82. [Crossref]  [PubMed]  [PMC] 
  12. Herman RA, Ayepa E, Shittu S, Fomet SS, Wang J. Essential oils and their applications - a mini review. Adv Nutr Food Sci. 2019;4(4). [Crossref] 
  13. Upadhyay RK. Essential Oils: Anti-microbial, antihelmintic, antiviral, anticancer and anti-insect properties. J. Appl. Biosci. 2010;36(1):1-22. [Link] 
  14. Damian P, Damian K. Aromatherapy: Scent and psyche: Using essential oils for physical and emotional well-being. 1st ed. Rochester: Inner Traditions Bear & Co; 1995.
  15. Belaiche P, Girault M. Traité de phytotherapie er d'aromatherapie. Vol 3. 1st ed. Gynécologie, Paris: Maloine; 1979.
  16. İşcan G. Antibacterial and anticandidal activities of common essential oil constituents. Rec. Nat. Prod. 2017;11(4):374-88. [Link] 
  17. Mickymaray S. Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens. Antibiotics (Basel). 2019;8(4):257. [Crossref]  [PubMed]  [PMC] 
  18. Fierascu RC, Fierascu I, Ortan A, Georgiev MI, Sieniawska E. Innovative approaches for recovery of phytoconstituents from medicinal/aromatic plants and biotechnological production. Molecules. 2020;25(2):309. [Crossref]  [PubMed]  [PMC] 
  19. Chattopadhyay D, Naik TN. Antivirals of ethnomedicinal origin: structure-activity relationship and scope. Mini Rev Med Chem. 2007;7(3):275-301. [Crossref]  [PubMed] 
  20. Ganesan A. The impact of natural products upon modern drug discovery. Curr Opin Chem Biol. 2008;12(3):306-17. [Crossref]  [PubMed] 
  21. Harvey AL. Natural products as a screening resource. Curr Opin Chem Biol. 2007;11(5):480-4. [Crossref]  [PubMed] 
  22. Pourghanbari G, Nili H, Moattari A, Mohammadi A, Iraji A. Antiviral activity of the oseltamivir and Melissa officinalis L. essential oil against avian influenza A virus (H9N2). Virusdisease. 2016;27(2):170-8. [Crossref]  [PubMed]  [PMC] 
  23. Janssen AM, Scheffer JJ, Baerheim Svendsen A. Antimicrobial activity of essential oils: a 1976-1986 literature review. Aspects of the test methods. Planta Med. 1987;53(5):395-8. [Crossref]  [PubMed] 
  24. Cohen S, Au S, Panté N. How viruses access the nucleus. Biochim Biophys Acta. 2011;1813(9):1634-45. [Crossref]  [PubMed] 
  25. Swamy MK, Akhtar MS, Sinniah UR. Antimicrobial properties of plant essential oils against human pathogens and their mode of action: an updated review. Evid Based Complement Alternat Med. 2016;2016:3012462. [Crossref]  [PubMed]  [PMC] 
  26. Yatim N, Albert ML. Dying to replicate: the orchestration of the viral life cycle, cell death pathways, and immunity. Immunity. 2011;35(4):478-90. [Crossref]  [PubMed] 
  27. De Clercq E. In search of a selective antiviral chemotherapy. Clin Microbiol Rev. 1997;10(4):674-93. [Crossref]  [PubMed]  [PMC] 
  28. De Clercq E. Antiviral drugs in current clinical use. J Clin Virol. 2004;30(2):115-33. [Crossref]  [PubMed] 
  29. Lou Z, Sun Y, Rao Z. Current progress in antiviral strategies. Trends Pharmacol Sci. 2014;35(2):86-102. [Crossref]  [PubMed]  [PMC] 
  30. Reichling J, Koch C, Stahl-Biskup E, Sojka C, Schnitzler P. Virucidal activity of a beta-triketone-rich essential oil of Leptospermum scoparium (manuka oil) against HSV-1 and HSV-2 in cell culture. Planta Med. 2005;71(12):1123-7. [Crossref]  [PubMed] 
  31. Sivropoulou A, Nikolaou C, Papanikolaou E, Kokkini S, Lanaras T, Arsenakis M. Antimicrobial, cytotoxic, and antiviral activities of salvia fructicosa essential oil. J Agric Food Chem. 1997;45(8):3197-201. [Crossref] 
  32. Minami M, Kita M, Nakaya T, Yamamoto T, Kuriyama H, Imanishi J. The inhibitory effect of essential oils on herpes simplex virus type-1 replication in vitro. Microbiol Immunol. 2003;47(9):681-4. [Crossref]  [PubMed] 
  33. Orhan İE, Özçelik B, Kartal M, Kan Y. Antimicrobial and antiviral effects of essential oils from selected Umbelliferae and Labiatae plants and individual essential oil components. Turk J Biol. 2012;36(3):239-46. [Link] 
  34. Romeilah RM, Fayed SA, Mahmoud GI. Chemical compositions, antiviral and antioxidant activities of seven essential oils. J. Appl. Sci. Res. 2010;6(1):50-62. [Link] 
  35. Brand Y, Linares VR, Betancur L, Duran-Garcia DC. Antiviral activity of Colombian Labiatae and Verbenaceae family essential oils and monoterpenes on Human Herpes viruses. J Essent Oil Res. 2016;28(2):130-7. [Crossref] 
  36. Benencia F, Courrèges MC. Antiviral activity of sandalwood oil against Herpes simplex viruses-1 and -2. Phytomedicine. 1999;6(2):119-23. [Crossref] 
  37. Schuhmacher A, Reichling J, Schnitzler P. Virucidal effect of peppermint oil on the enveloped viruses herpes simplex virus type 1 and type 2 in vitro. Phytomedicine. 2003;10(6-7):504-10. [Crossref]  [PubMed] 
  38. Garozzo A, Timpanaro R, Bisignano B, Furneri PM, Bisignano G, Castro A. In vitro antiviral activity of Melaleuca alternifolia essential oil. Lett Appl Microbiol. 2009;49(6):806-8. [Crossref]  [PubMed] 
  39. Schnitzler P, Schön K, Reichling J. Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture. Pharmazie. 2001;56(4):343-7. [PubMed] 
  40. Astani A, Reichling J, Schnitzler P. Comparative study on the antiviral activity of selected monoterpenes derived from essential oils. Phytother Res. 2010;24(5):673-9. [Crossref]  [PubMed]  [PMC] 
  41. Carson CF, Ashton L, Dry L, Smith DW, Riley TV. Melaleuca alternifolia (tea tree) oil gel (6%) for the treatment of recurrent herpes labialis. J Antimicrob Chemother. 2001;48(3):450-1. [Crossref]  [PubMed] 
  42. Groves MJ. Genital Herpes: A Review. Am Fam Physician. 2016;93(11):928-34. [PubMed] 
  43. Koch C, Reichling J, Schneele J, Schnitzler P. Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine. 2008;15(1-2):71-8. [Crossref]  [PubMed] 
  44. Allahverdiyev A, Duran N, Ozguven M, Koltas S. Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2. Phytomedicine. 2004;11(7-8):657-61. [Crossref]  [PubMed] 
  45. Setzer WN. Essential oils as complementary and alternative medicines for the treatment of influenza. Am Journal Essent Oil. 2016;4(4):16-22. [Link] 
  46. Battaglia S. The Complete Guide to Aromatherapy. 3rd ed. Brisbane: Black Pepper Creative; 2018.
  47. Vimalanathan S, Hudson J. Anti-influenza virus activity of essential oils and vapors. Am Journal Essent Oil. 2014;2(1):47-53. [Link] 
  48. Wu S, Patel KB, Booth LJ, Metcalf JP, Lin HK, Wu W. Protective essential oil attenuates influenza virus infection: an in vitro study in MDCK cells. BMC Complement Altern Med. 2010;10:69. [Crossref]  [PubMed]  [PMC] 
  49. Brochot A, Guilbot A, Haddioui L, Roques C. Antibacterial, antifungal, and antiviral effects of three essential oil blends. Microbiologyopen. 2017;6(4):e00459. [Crossref]  [PubMed]  [PMC] 
  50. Pyankov OV, Usachev EV, Pyankova O, Agranovski IE. Inactivation of airborne influenza virus by tea tree and eucalyptus oils. Aerosol Sci Tech. 2012;46(12):1295-302. [Crossref] 
  51. Usachev EV, Pyankov, OV, Usacheva OV, Agranovski IE. Antiviral activity of tea tree and eucalyptus oil aerosol and vapor. J Aerosol Sci. 2013;59:22-30. [Crossref] 
  52. Wen CC, Kuo YH, Jan JT, Liang PH, Wang SY, Liu HG, et al. Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med Chem. 2007;50(17):4087-95. [Crossref]  [PubMed] 
  53. Won JN, Lee SY, Song DS, Poo H. Antiviral activity of the plant extracts from Thuja orientalis, Aster spathulifolius, and Pinus thunbergii against influenza virus A/PR/8/34. J Microbiol Biotechnol. 2013;23(1):125-30. [Crossref]  [PubMed] 
  54. Ulasli M, Gurses SA, Bayraktar R, Yumrutas O, Oztuzcu S, Igci M, et al. The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family. Mol Biol Rep. 2014;41(3):1703-11. [Crossref]  [PubMed]  [PMC] 
  55. Loizzo MR, Saab AM, Tundis R, Statti GA, Menichini F, Lampronti I, et al. Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species. Chem Biodivers. 2008;5(3):461-70. [Crossref]  [PubMed]  [PMC] 
  56. Barbour EK, Yaghi RK, Jaber LS, Shaib HA, Harakeh S. Safety and antiviral activity of essentail oil against avian influenza and Newcastle disease viruses. Intern J. Appl Res Vet Med. 2010;8(1):60-4. [Link] 
  57. Jackwood MW, Rosenbloom R, Petteruti M, Hilt DA, McCall AW, Williams SM. Avian coronavirus infectious bronchitis virus susceptibility to botanical oleoresins and essential oils in vitro and in vivo. Virus Res. 2010;149(1):86-94. [Crossref]  [PubMed]  [PMC] 
  58. Schnitzler P, Koch C, Reichling J. Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood. Antimicrob Agents Chemother. 2007;51(5):1859-62. [Crossref]  [PubMed]  [PMC] 
  59. Reichling J, Schnitzler P, Suschke U, Saller R. Essential oils of aromatic plants with antibacterial, antifungal, antiviral, and cytotoxic properties--an overview. Forsch Komplementmed. 2009;16(2):79-90. [Crossref]  [PubMed] 
  60. Astani A, Reichling J, Schnitzler P. Screening for antiviral activities of isolated compounds from essential oils. Evid Based Complement Alternat Med. 2011;2011:253643. [Crossref]  [PubMed]  [PMC] 
  61. Siddiqui YM, Ettayebi M, Haddad A, Al-Ahdal MN . Effect of essential oils on the enveloped viruses: antiviral activity of oregano and clove oils on herpes simplex virus type 1 and Newcastle disease virus. Medical Science Research. 1996:24(3):185-6. [Link] 

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"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com