Journal of Literature Pharmacy Sciences

Baikaleinin Apoptozis Üzerine Etkisi
Effect of Baikalein on Apoptosis
Ecenur ÖZKULa, Elvan YILMAZ AKYÜZb
aBahçeşehir Üniversitesi Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, İstanbul, TÜRKİYE
bSağlık Bilimleri Üniversitesi Hamidiye Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, İstanbul, TÜRKİYE
J Lit Pharm Sci. 2021;10(1):21-8
doi: 10.5336/pharmsci.2020-76522
Article Language: TR
ÖZET
Kökünde 50'den fazla flavonoid izole edilebilen Scutellaria türleri üzerinde son yıllarda çok sayıda araştırma yapılmaktadır. Fizyolojik aktivitesinden sorumlu en önemli aktif bileşeni ise baikalein olarak bildirilmiştir. Baikaleinin pek çok olumlu etkisinin yanında üzerine en çok çalışılan özelliği antikanserojen özellikleridir. En önemli aktivitesinin ise apoptozis üzerindeki olumlu etkileri olduğu düşünülmektedir. Apoptoz sürecinin planlı ilerlemesi, kanser gelişimi ve ilerlemesinde önemli bir süreçtir. Bu nedenle apoptoz birçok tedavi stratejisinin hedefidir. Baikaleinin ilk mekanizması hücrede proapoptotik, antiapoptotik Bcl-2 ailesi proteinlerinin oranını regüle ederek hücrenin apoptoza eğilimini düzenlemesidir. Radikal oksijen türleri aracılığıyla apoptozisi düzenlemesi ise diğer bir antikanser etki mekanizması olarak değerlendirilmektedir. Tanımlanmış olan diğer mekanizması ise apoptoz, büyüme inhibisyonu ve hücre döngüsünün durdurulmasında yer alan genlerin ekspresyonunu düzenleyen tümör baskılayıcı bir protein olan p53'ü yukarı regüle etmesidir. Kanser gelişimi ile birlikte diyabetin gelişiminde de önemli bir rolü olduğu belirlenen araşidonik asit izoformlarından birisi olan 12-lipoksijenaz üretimini inhibe etmesi ise üzerine çalışılan diğer bir önemli mekanizmasıdır. Bu derleme, baikaleinin kanser tedavisinde kullanılabileceği düşünülen ve üzerine en çok çalışılan etki mekanizmalarını açıklamak amacıyla yazılmıştır. İn vitro ve hayvan deneylerinde gösterilen kanser tedavisi ile ilgili umut vadeden çalışmalar göz önünde bulundurularak, baikalein kullanımının etkilerinin belirleneceği klinik çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler: Apoptozis; baikalein; flavonoid
ABSTRACT
In recent years, a lot of research has been studied on Scutellaria species, which can be isolated more than 50 flavonoids at the root. The most important active ingredient responsible for the physiological activity of Scutellaria species has been reported as baicalein. The most studied feature of baicalein is its anti-carcinogenic properties. Its most important activity has been reported as inducing apoptosis. The planned progression of the apoptosis process is an important process in cancer development and progression. Therefore, apoptosis is the target of many treatment strategies. The first mechanism of baicalein is to regulate the cell's tendency to apoptosis by regulating the rate of proapoptotic, antiapoptotic Bcl-2 family proteins in the cell. Regulation of apoptosis through radical oxygen species is considered as another anti-cancer mechanism of action. Another defined mechanism is; Apoptosis upregulates p53, a tumor suppressing protein that regulates the expression of genes involved in growth inhibition and cell cycle arrest. In addition to cancer development, it is another important mechanism studied to inhibit the production of 12-lipoxygenase, which is one of the arachidonic acid isoforms that has an important role in the development of diabetes. The purpose of this review is to explain the most studied mechanisms of action of baicalein that can be used in cancer treatment. Considering the promising studies on cancer treatment in in vitro and animal experiments, clinical studies on the use of baicalein are needed.

Keywords: Apoptosis; baicalein; flavonoid
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Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com