Turkiye Klinikleri Journal of Anesthesiology Reanimation

.: ORIGINAL RESEARCH
Comparing Effects of Midazolam and Dexmedetomidine Sedation on Ultrasound Guided Infraclavicular Nerve Block for Upper Extremity Orthopedic Surgeries
Ultrasonografi Kılavuzluğunda İnfraklaviküler Blok ile Üst Ekstremite Ortopedi Cerrahisi Geçiren Hastalarda Midazolam ve Deksmedetomidin ile Sedasyonun Periferik Sinir Bloğu Üzerine Etkilerinin Karşılaştırılması
Fatih ÇİFTÇİa, Yasemin ALTANb
aClinic of Anesthesiology and Reanimation, Mehmet Akif İnan Training and Research Hospital, Şanlıurfa, TURKEY
bClinic of Anesthesiology and Reanimation, University of Health Sciences Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, TURKEY
Turkiye Klinikleri J Anest Reanim. 2019;17(1):8-15
doi: 10.5336/anesthe.2019-64922
Article Language: EN
Full Text
ABSTRACT
 Objective: Sedation is an important step of regional anesthesia, the effects of sedative agents on nerve block characteristics are often subjects of scientific researches. In our study, we aimed to compare the effects of dexmedetomidine and midazolam sedation on sensory and motor onset and termination time after infraclavicular nerve block. Material and Methods: After local ethics committee approval and patients written informed consents were obtained, 60 patients between the ages of 18-65 years, with an American Society of Anesthesiologists (ASA) classification I-II who received infraclavicular nerve block randomized into two groups. Group D received 0.8 μg/kg bolus continued with 0.2-0.7 μg/kg/h of maintenance dose of dexmedetomidine group M received 0.05mg/kg bolus continued with 0.02-0.2 mg/kg/h of maintenance dose of midazolam. The patient's demographic data heart rate pulse, mean arterial pressure, sensory and motor block onset and termination time were analyzed. Results: Heart rate and mean arterial pressure were lower in dexmedetomidine group. Sensory (Group D: 8.6±2.4 Group M: 16.2±1.8) and motor block onset time (Group D: 14.2±1.6, Group M: 21.4±2.3) was shorter in dexmedetomidine group. Sensory (Group D: 715.4±41.1 min Group M: 518.1±44.2 min) and motor block termination time (Group D: 613.6±38.1 min Group M: 421.3±37.2 min) were longer in dexmedetomidine group. Conclusion: The use of dexmedetomidine for sedation on patients who received ultrasound-guided infraclavicular block for upper extremity surgeries resulted earlier onset time to sensory and motor block and prolonged sensory and motor block termination time.

Keywords: Dexmedetomidine; midazolam; infraclavicular nerve block
ÖZET
 Amaç: Rejyonel anestezinin önemli bir basamağı olan sedasyon amacıyla kullanılan sedatif ajanların sinir bloğu karakteristiğine etkileri sıklıkla bilimsel araştırmalara konu olmaktadır. Çalışmamızda, deksmedetomidin ve midazolam ile sedasyonun infraklaviküler sinir bloğu başlama ve sonlanma zamanına etkilerini karşılaştırmayı amaçladık. Gereç ve Yöntemler: Yerel etik kurul onayı ve yazılı bilgilendirilmiş onam formu alındıktan sonra, 18-65 yaş aralığında, Amerikan Anesteziyologlar Birliği (ASA) I-II grubu İnfraklaviküler blok yapılacak 60 hasta randomize edilerek iki gruba ayrıldı. Grup D'ye sedasyon amacıyla 0,8 μg/kg deksmedetomidin bolus sonrasında 0,2-0,7 μg/kg/saat idame tedavi verildi, Grup M'ye 0,05 mg/kg midazolam bolus sonrasında 0,02-0,2 mg/kg/saat idame tedavi verildi. Hastaların demografik verileri, kalp tepe atımı, ortalama arteriyel basınç, duyusal ve motor blok başlama ve sonlanma zamanı analiz edildi. Bulgular: Grupların demografik verileri benzerdir, kalp tepe atımı ve ortalama arteriyel basınç deksmedetomidin grubunda daha düşük bulundu. Duyusal (Grup D: 8,6±2,4 dk, Grup M: 16,2±1,8 dk) ve motor blok başlama zamanı (Grup D: 14,2±1,6 dk, Grup M: 21,4±2,3 dk) Deksmedetomidin grubunda midazolam grubuna göre daha kısa, duyusal (Grup D: 715,4±41,1 dk, Grup M: 518,1±44,2 dk) ve motor blok sonlanma zamanı (Grup D: 613,6±38,1 dk, Grup M: 421,3±37,2 dk) ise daha uzun olarak bulundu. Sonuç: Ultrasonografi kılavuzluğunda infraklaviküler blok yapılmış hastalarda sedasyon amacıyla deksmedetomidin kullanılması midazolama kıyasla, blok başlama süresini kısaltıp, blok sonlanma süresini uzatmaktadır.

Anahtar Kelimeler: Deksmedetomidin; midazolam; infraklaviküler sinir bloğu
REFERENCES:
  1. Borgeat A,Ekatodramis G,Dumont C.An evaluationofthe infraclavicularblockvia amodifiedapproach oftheRaj technique.Anesth Analg. 2001;93(2):436-41. [Crossref] [PubMed]
  2. Mantz J, Josserand J, Hamada S. Dexmedetomidine: new insights. Eur J Anaes-thesiol. 2011;28(1):3-6. [Crossref] [PubMed]
  3. ChenK, LuZ,Xin YC,CaiY, ChenY,Pan SM.Alpha-2agonists forlong-termsedation duringmechanicalventilation incriticallyill patients.CochraneDatabase SystRev. 2015;1:CD010269. [Crossref] [PMC]
  4. Schnabel A, Reichl SU, Weibel S, Kranke P,Zahn PK, Pogatzki-Zahn EM, et al. Efficacy and safety of dexmedetomidine in peripheral nerve blocks: a meta-analysis and trial sequential analysis. Eur J Anaesthesiol. 2018;35(10):745-58. [Crossref] [PubMed]
  5. Schulz KF, Altman DG, Moher D; CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c332. [Crossref] [PubMed] [PMC]
  6. Ramsay MA, Savege TM, Simpson BR, Goodwin R. Controlled sedation with alphaxalonealphadolone. Br Med J. 1974;2(5920):656-9. [Crossref] [PubMed] [PMC]
  7. AldreteJA. Thepost-anesthesiarecovery scorerevisited.J ClinAnesth.1995;7(1):8991. [Crossref]
  8. BromagePR. Anevaluationof bupivacainein epiduralanalgesia forobstetrics.Can Anaesth SocJ. 1969;16(1):46-56.[Crossref] [PubMed]
  9. Scheinin M, Schwinn DA. The locus coeruleus. Site of hypnotic actions of alpha 2adrenoceptor agonists?Anesthesiology. 1992;76(6):873-5. [Crossref] [PubMed]
  10. Bindu B, Pasupuleti S, Gowd UP, Gorre V, Murthy RR, Laxmi MB. A double blind, randomized, controlled trial to study the effect of dexmedetomidine on hemodynamic and recovery responses during tracheal extubation. J Anesthesiol Clin Pharmacol. 2013;29(2):162-7. [Crossref] [PubMed] [PMC]
  11. Kwon Y, Hwang SM, Lee JJ, Kim JH. The effectof dexmedetomidineasan adjuvantto ropivacaineon thebispectralindex forsupraclavicularbrachial plexusblock.Korean J Anesthesiol. 2015;68(1): 32-6. [Crossref]
  12. Brummett CM, Padda AK, Amodeo FS, Welch KB, Lydic R. Perineural dexmedetomidine added to ropivacaine causes a dosedependent increase in the duration of thermal antinociception in sciatic nerve block in rat. Anesthesiology. 2009;111(5): 11119. [Crossref] [PubMed] [PMC]
  13. Marhofer D, Kettner SC, Marhofer P, Pils S, Weber M, Zeitlinger M. Dexmedetomidine as an adjuvant to ropivacaine prolongs peripheral nerve block: a volunteer study. Br J Anaesth. 2013;110(3):438-42. [Crossref] [PubMed]
  14. KathuriaS, GuptaS,Dhawan I.Dexmedetomidineasan adjuvanttoropivacaine insupraclavicular brachial plexus block. Saudi J Anaesth.2015;9(2):148-54. [Crossref] [PubMed] [PMC]
  15. AbdallahFW, DwyerT,Chan VW,Niazi AU, Ogilvie-HarrisDJ,Oldfield S,etal. IVandperineuraldexmedetomidinesimilarly prolongthe durationof analgesiaafterinterscalene brachialplexusblock: arandomized,threearm,triple-masked,placebo-controlled trial. Anesthesiology.2016;124(3):683-95. [Crossref] [PubMed]
  16. Rutkowska K, Knapik P, Misiolek H. The effect of dexmedetomidine sedation on brachial plexus block in patients with end-stage renal disease. Eur J Anaesthesiol.2009;26(10):8515. [Crossref] [PubMed]
  17. Schnabel A, Reichl SU, Weibel S, Kranke P,Zahn PK, Pogatzki-Zahn EM, et al. Efficacy and safety of dexmedetomidine in peripheralnerve blocks: a meta-analysis and trial sequential analysis. Eur J Anaesthesiol. 2018;35(10):745-8. [Crossref] [PubMed]
  18. KangR, JeongJS,Yoo JC, LeeJH, ChoiSJ, GwakMS,et al.Effectivedose ofintravenous dexmedetomidineto prolongtheanalgesic durationofinterscalene brachialplexusblock: asingle-center, prospective, double-blind, randomized controlled trial. Reg Anesth Pain Med. 2018;43(5):488-95. [Crossref] [PubMed]
  19. Kumar G, Dubey PK, Sanjeev OP. Effect of midazolam and dexmedetomidine sedation on the onset and duration of supraclavicular brachial plexus block:a randomisedcom-parative study. Turk J Anaesthesiol Reanim. 2018;46(3):201-7.[Crossref] [PubMed] [PMC]
  20. Schnabel A, Meyer-Frießem CH, Reichl SU, Zahn PK, Pogatzki-Zahn EM. Is intraoperative dexmedetomidine a new option for post-operative pain treatment? A meta-analysis of randomized controlled trials. Pain. 2013;154(7): 1140-9. [Crossref] [PubMed]
  21. SongJH, ShimHY,Lee TJ,JungJK, ChaYD, LeeDI, etal.Comparison ofdexmedetomidine andepinephrine asanadjuvant to1% mepivacaineinbrachial plexusblock.Korean J Anesthesiol.2014;66(4):283-9. [Crossref] [PubMed] [PMC]
  22. EbertTJ, HallJE,Barney JA,UhrichTD, ColincoMD.The effectsofincreasing plasma concentrationsofdexmedetomidine inhumans.Anesthesiology. 2000;93(2):382-94.[Crossref] [PubMed]
  23. GuoTZ, JiangJY,Buttermann AE,MazeM. Dexmedetomidineinjectioninto thelocus ceruleusproduces antinociception.Anesthesiology.1996; 84(4):873-81.[Crossref] [PubMed]
  24. Ghai B, Makkar JK, Chari P, Rao KL. Addition of midazolam to continuous postoperative epidural bupivacaine infusion reduces requirement for rescue analgesia in children undergoing upper abdominal and flank surgery. J Clin Anesth. 2009;21(2):113-9. [Crossref] [PubMed]
  25. NivD, DavidovichS,Geller E,UrcaG. Analgesicandhyperalgesic effectsofmidazolam: dependence on route of administration. AnesthAnalg.1988;67(12):1169-73. [Crossref] [PubMed]

.: Up To Date

Login

 Forgot your password?

 New Registration  

Contact

Ortadoğu Reklam Tanıtım Yayıncılık Turizm Eğitim İnşaat Sanayi ve Ticaret A.Ş.

.: Address

Turkocagi Caddesi No:30 06520 Balgat / ANKARA
Phone: +90 312 286 56 56
Fax: +90 312 220 04 70
E-mail: info@turkiyeklinikleri.com

.: Manuscript Editing Department

Phone: +90 312 286 56 56/ 2
E-mail: yaziisleri@turkiyeklinikleri.com

.: English Language Redaction

Phone: +90 312 286 56 56/ 145
E-mail: tkyayindestek@turkiyeklinikleri.com

.: Marketing Sales-Project Department

Phone: +90 312 286 56 56/ 142
E-mail: reklam@turkiyeklinikleri.com

.: Subscription and Public Relations Department

Phone: +90 312 286 56 56/ 118
E-mail: abone@turkiyeklinikleri.com

.: Customer Services

Phone: +90 312 286 56 56/ 118
E-mail: satisdestek@turkiyeklinikleri.com

1. TERMS OF USE

1.1. To use the web pages with http://www.turkiyeklinikleri.com domain name or the websites reached through the sub domain names attached to the domain name (They will be collectively referred as "SITE"), please read the conditions below. If you do not accept these terms, please cease to use the "SITE." "SITE" owner reserves the right to change the information on the website, forms, contents, the "SITE," "SITE" terms of use anytime they want.

1.2. The owner of the "SITE" is Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. (From now on it is going to be referred as "Turkiye Klinikleri", shortly) and it resides at Turkocagi cad. No:30, 06520 Balgat Ankara. The services in the "SITE" are provided by "Turkiye Klinikleri."

1.3. Anyone accessing the "SITE" with or without a fee whether they are a natural person or a legal identity is considered to agree these terms of use. In this contract hereby, "Turkiye Klinikleri" may change the stated terms anytime. These changes will be published in the "SITE" periodically and they will be valid when they are published. Any natural person or legal identity benefiting from and reaching to the "SITE" are considered to be agreed to any change on hereby contract terms done by "Turkiye Klinikleri."

1.4. The "Terms of Use" hereby is published in the website with the last change on March 30th 2014 and the "SITE" is activated by enabling the access to everyone. The "Terms of Use" hereby is also a part of the any "USER Contract" was and/or will be done with the users using "Turkiye Klinikleri" services with or without a fee an inseparable.

2. DEFINITIONS

2.1. "SITE": A website offering different kind of services and context with a certain frame determined by "Turkiye Klinikleri" and it is accessible on-line on http://www.turkiyeklinikleri.com domain name and/or subdomains connected to the domain name.

2.2. USER: A natural person or a legal identity accessing to the "SITE" through online settings.

2.3. LINK: A link enabling to access to another website through the "SITE", the files, the context or through another website to the "SITE", the files and the context.

2.4. CONTEXT: Any visual, literary and auditory images published in the "Turkiye Klinikleri", "SITE" and/or any website or any accessible information, file, picture, number/figures, price, etc.

2.5. "USER CONTRACT": An electronically signed contract between a natural or a legal identity benefiting from special services "Turkiye Klinikleri" will provide and "Turkiye Klinikleri".

3. SCOPE OF THE SERVICES

3.1. "Turkiye Klinikleri" is completely free to determine the scope and quality of the services via the "SITE".

3.2. To benefit the services of "Turkiye Klinikleri" "SITE", the "USER" must deliver the features that will be specified by "Turkiye Klinikleri". "Turkiye Klinikleri" may change this necessity any time single-sided.

3.3. Not for a limited number, the services "Turkiye Klinikleri" will provide through the "SITE" for a certain price or for free are;

- Providing scientific articles, books and informative publications for health industry.

- Providing structural, statistical and editorial support to article preparation stage for scientific journals.

4. GENERAL PROVISIONS

4.1. "Turkiye Klinikleri" is completely free to determine which of the services and contents provided in the "SITE" will be charged.

4.2. People benefiting from the services provided by "Turkiye Klinikleri" and using the website can use the "SITE" only according to the law and only for personal reasons. Users have the criminal and civil liability for every process and action they take in the "SITE". Every USER agrees, declares and undertakes that they will not proceed by any function or action infringement of rights of "Turkiye Klinikleri"s and/or other third parties', they are the exclusive right holder on usage, processing, storage, made public and revealing any written, visual or auditory information reported to Turkiye Klinikleri" and/or "SITE" to the third parties. "USER" agrees and undertakes that s/he will not duplicate, copy, distribute, process, the pictures, text, visual and auditory images, video clips, files, databases, catalogs and lists within the "SITE", s/he will not be using these actions or with other ways to compete with "Turkiye Klinikleri", directly or indirectly.

4.3. The services provided and the context published within the "SITE" by third parties is not under the responsibility of "Turkiye Klinikleri", institutions collaborated with "Turkiye Klinikleri", "Turkiye Klinikleri" employee and directors, "Turkiye Klinikleri" authorized salespeople. Commitment to accuracy and legality of the published information, context, visual and auditory images provided by any third party are under the full responsibility of the third party. "Turkiye Klinikleri" does not promise and guarantee the safety, accuracy and legality of the services and context provided by a third party.

4.4. "USER"s cannot act against "Turkiye Klinikleri", other "USER"s and third parties by using the "SITE". "Turkiye Klinikleri" has no direct and/or indirect responsibility for any damage a third party suffered or will suffer regarding "USER"s actions on the "SITE" against the rules of the hereby "Terms of Use" and the law.

4.5. "USER"s accept and undertake that the information and context they provided to the "SITE" are accurate and legal. "Turkiye Klinikleri" is not liable and responsible for promising and guaranteeing the verification of the information and context transmitted to "Turkiye Klinikleri" by the "USER"s, or uploaded, changed and provided through the "SITE" by them and whether these information are safe, accurate and legal.

4.6. "USER"s agree and undertake that they will not perform any action leading to unfair competition, weakening the personal and commercial credit of "Turkiye Klinikleri" and a third party,  encroaching and attacking on personal rights within the "SITE" in accordance with the Turkish Commercial Code Law.

4.7. "Turkiye Klinikleri" reserves the right to change the services and the context within the "SITE"  anytime. "Turkiye Klinikleri" may use this right without any notification and timelessly. "USER"s have to make the changes and/or corrections "Turkiye Klinikleri" required immediately. Any changes and/or corrections that are required by "Turkiye Klinikleri", may be made by "Turkiye Klinikleri" when needed. Any harm, criminal and civil liability resulted or will result from changes and/or corrections required by "Turkiye Klinikleri" and were not made on time by the "USER"s belongs completely to the users.

4.8. "Turkiye Klinikleri" may give links through the "SITE" to other websites and/or "CONTEXT"s and/or folders that are outside of their control and owned and run by third parties. These links are provided for ease of reference only and do not hold qualification for support the respective web SITE or the admin or declaration or guarantee for the information inside. "Turkiye Klinikleri" does not hold any responsibility over the web-sites connected through the links on the "SITE", folders and context, the services or products on the websites provided through these links or their context.

4.9. "Turkiye Klinikleri" may use the information provided to them by the "USERS" through the "SITE" in line with the terms of the "PRIVACY POLICY" and "USER CONTRACT". It may process the information or classify and save them on a database. "Turkiye Klinikleri" may also use the USER's or visitor's identity, address, e-mail address, phone number, IP number, which sections of the "SITE" they visited, domain type, browser type, date and time information to provide statistical evaluation and customized services.

5. PROPRIETARY RIGHTS

5.1. The information accessed through this "SITE" or provided by the users legally and all the elements (including but not limited to design, text, image, html code and other codes) of the "SITE" (all of them will be called as studies tied to "Turkiye Klinikleri"s copyrights) belongs to "Turkiye Klinikleri". Users do not have the right to resell, process, share, distribute, display or give someone permission to access or to use the "Turkiye Klinikleri" services, "Turkiye Klinikleri" information and the products under copyright protection by "Turkiye Klinikleri". Within hereby "Terms of Use" unless explicitly permitted by "Turkiye Klinikleri" nobody can reproduce, process, distribute or produce or prepare any study from those under "Turkiye Klinikleri" copyright protection.

5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com