Journal of Traditional Medical Complementary Therapies

.: ORIGINAL RESEARCH
Comparison of the Effects of Hyperbaric Oxygen and Medical Ozone Therapy on Wound Healing in the Experimental Burn Wound Model
Deneysel Yanık Modelinde Hiperbarik Oksijen ve Medikal Ozon Tedavisinin Yara İyileşmesi Üzerine Etkilerinin Karşılaştırılması
Zeki YAŞARa, Perçin KARAKOL CAŞKANb, Emin KAPIc, Mehmet BOZKURTb
aPrivate Physician, İstanbul, TURKEY
bDepartment of Plastic, Reconstructive and Aesthetic Surgery, Health and Sciences University Bağcılar Training and Research Hospital, İstanbul, TURKEY
cDepartment of Plastic, Reconstructive and Aesthetic Surgery, Health and Sciences University Adana City Training and Research Hospital, Adana, TURKEY
J Tradit Complem Med. 2020;3(3):352-60
doi: 10.5336/jtracom.2020-75041
Article Language: EN
Full Text
ABSTRACT
 Objective: Burn injury is a type of injury which is the disruptin of skin and organs by the effects of heat, electrical current, chemical caustic or burning agents. The purposes of daily burn care are removing of necrotic tissue, prevention of bacterial contamination, control of travma, stimulation of epithelization and protection of systemic complications. In this study, the effects of hyperbaric oxygen and ozone therapy were investigated, and used as adjuvant therapy in burn management, on burned areas utilizing experimental burn model. Material and Methods: In this study, 28 Wistar albino rats weighing 200-220 gr were used and divided into four groups. 10% burn defect areas were occured in all experiments. In the first group, rats were treated with hyperbaric oxygen. Medical ozone therapy was applied to the second group. In the third group, only debridement was used as treatment. Any treatment options were not used to rats in the fourth group. Results: The analysis revealed no statistically significant difference of burns surface areas between Groups 1 and 2, while a significant reduction were noted in Groups 1 and 2 when compared to the other groups. On histopathologic examination of the Groups 1 and 2 we observed a significant decrease in the inflammation and fibrosis rates when compared with other groups. Conclusion: As a result, we observed the affirmative effects of hyperbaric oxygen and ozone therapy on burn management. We suggest that these treatment modalities can be added to standart treatment options as adjuvant therapy. We also think that large researches are needed to support this issue.

Keywords: Hyperbaric oxygen; medical ozone; burns
ÖZET
 Amaç: Yanık hasarı; derinin veya organların ısı, elektrik akımı, kimyasal veya yakıcı bir ajan etkisi ile tahrip olması şeklinde gerçekleşen bir yaralanma şeklidir. Günlük yanık bakımının hedefleri nekrotik dokuları kaldırmak, bakteriyel kontaminasyonu önlemek, travmayı kontrol etmek, epitelizasyonu uyarmak ve sistemik komplikasyonlardan korunmaktır. Bu çalışmada; deneysel yanık modelinde, adjuvan tedavi olarak kullanılan hiperbarik oksijen ve medikal ozon tedavilerinin etkileri incelenmiştir.Gereç ve Yöntemler: Çalışmaya, ağırlıkları 200-220 gr. ağırlığında 28 adet Wistar albino sıçan dahil edildi ve 4 deney grubu oluşturuldu. Tüm deneklerde %10 yanık yüzey alanı meydana getirildi. Birinci grup hiperbarik oksijen tedavisi aldı. İkinci gruba medikal ozon tedavisi uygulandı. Üçüncü gruba sadece debridman uygulandı. Dördüncü gruptaki sıçanlara ise herhangi bir tedavi uygulanmadı. Bulgular: Grup 1 ve 2 arasında yanık yüzey alanı açısından istatistiksel açıdan anlamlı bir farklılık gözlenmez iken, Grup 1 ve 2 ile diğer gruplar arasında anlamlı derecede azalma gözlendi. Histopatolojik incelemede Grup 1 ve 2'de, diğer gruplara kıyasla inflamasyon ve fibrosis oranlarında belirgin azalma gözlendi. Sonuç: Sonuç olarak, yanık tedavisinde hiperbarik oksijen ve medikal ozon tedavisinin yararlı etkileri olduğunu gözlemledik. Bu tedavilerin standart yanık tedavisine ek olarak uygulanabileceğini düşünmekteyiz. Ancak, bu konuda geniş çaplı araştırmaların yapılması gerektiği kanaatindeyiz.

Anahtar Kelimeler: Hiperbarik oksijen; medikal ozon; yanık
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