Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Demir Eksikliği Anemisinin Gözün Arka Segment Bulgularına Etkisi: Kesitsel Araştırma
Effect of Iron Deficiency Anemia on Posterior Segment Findings of the Eye: Cross-Sectional Research
Sinem KESERa , Berçem AFŞAR KARATEPEb , Fatih Cem GÜLa , Sabiha GÜNGÖR KOBATc
aElazığ Fethi Sekin Şehir Hastanesi Göz Hastalıkları Kliniği, Elazığ, Türkiye
bElazığ Fethi Sekin Şehir Hastanesi İç Hastalıkları Kliniği, Elazığ, Türkiye
cFırat Üniversitesi Tıp Fakültesi, Göz Hastalıkları AD, Elazığ, Türkiye
Turkiye Klinikleri J Ophthalmol. 2025;34(3):113-9
doi: 10.5336/ophthal.2024-108001
Article Language: TR
Full Text
ÖZET
 Amaç: Bu çalışmanın amacı Demir Eksikliği Anemisi (DEA) olan olgularda santral makula, retinal sinir lifi (superior, inferior, nazal ve temporal kadranlar) ve koroid (santral, nazal ve temporal) kalınlıklarının tedavi öncesi ve sonrası Optik Koherens Tomografi (OKT) ile değerlendirilmesidir. Gereç ve Yöntemler: Bu prospektif çalışma, 2023 Mart ve Nisan ayları arasında DEA nedeniyle iç hastalıkları polikliniğinden göz polikliniğine yönlendirilen 19-54 yaş aralığındaki 40 kadın olgu ile gerçekleştirilmiştir. Tüm olgulara tam bir oftalmolojik muayene yapıldıktan sonra; tedaviye başlamadan önce ve tedaviden 3 ay sonrasında Spectral-Domain OKT ile santral makuler, subfoveal, nazal (1.000 mikron) ve temporal (1.000 mikron) koroidal kalınlık ve 4 kadranda retina sinir lifi kalınlıkları (RSLK) değerlendirilmiştir. Bulgular: Çalışmaya dâhil edilen 40 kadın olgunun ortalama yaşı 34,74±9,64 olarak hesaplanmıştır. DEA olan olguların tedavi öncesi ve tedaviden 3 ay sonrası değerleri karşılaştırıldığında, tedavi sonrası santral, nazal ve temporal koroid kalınlıklarında anlamlı derece artış olduğu tespit edilirken (tüm değerler için p<0,001), santral makula kalınlığında tedavi öncesi ve sonrasında anlamlı bir fark gözlenmemiştir (p=0.194). RSLK superior, inferior, nazal ve temporal kadranlarda da tedavi öncesi ve sonrasında anlamlı fark gözlenmemiştir (p=0,171, p=0,508, p=0,233 ve p=0,977). Sonuç: Sonuç olarak çalışmadan elde edilen bulgular, DEA olgularında vücudun yoğun damar ağına sahip bölgelerinden biri olan koroid dokusunda değişikliğe neden olduğunu destekler niteliktedir.

Anahtar Kelimeler: Demir eksikliği anemisi; retina sinir lifi; koroid; makula; optik koherens tomografi
ABSTRACT
 Objective: The aim of this study was to evaluate the central macula, retinal nerve fiber (superior, inferior, nasal and temporal quadrants) and choroidal (central, nasal and temporal) thicknesses in cases with Iron Deficiency Anemia (IDA) before and after treatment with Optical Coherence Tomography (OCT). Material and Methods: This prospective study was conducted with 40 female patients aged 19-54 years who were referred from the internal medicine outpatient clinic to the ophthalmology outpatient clinic due to IDA between March and April 2023. After a complete ophthalmological examination was performed on all cases; central macular, subfoveal, nasal (1,000 microns) and temporal (1,000 microns) choroidal thickness and retinal nerve fiber thickness (RNLF) in 4 quadrants were evaluated with Spectral-Domain OCT before starting treatment and 3 months after treatment. Results: The mean age of the 40 female patients included in the study was calculated as 34.74±9.64. When the values of the case with IDA before and 3 months after treatment were compared, it was determined that there was a significant increase in the central, nasal and temporal choroidal thicknesses after treatment (for all values p<0.001), while no significant difference was observed in the central macular thickness before and after treatment (p=0.194). There was also no significant difference in the RNLF superior, inferior, nasal and temporal quadrants before and after treatment (p=0.171, p=0.508, p=0.233 and p=0.977). Conclusion: In conclusion, the findings obtained from the study support the idea that IDA causes changes in the choroidal tissue, which is one of the regions of the body with a dense vascular network.

Keywords: Iron deficiency anemia; retinal nerve fiber; choroid; macula; optical coherence tomography
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