Turkiye Klinikleri Journal of Internal Medicine

.: ORIGINAL RESEARCH
Effect of Body Weight Reduction on Serum Irisin Levels: Experimental Study
Vücut Ağırlığı Azalmasının Serum İrisin Düzeylerine Etkisi: Deneysel Çalışma
Özlem ÇAKIR MADENCİa, Müjgan KAYA TUNAb, Özlem HÜRMEYDANa, Asuman ORÇUNa
aLaboratory of Biochemistry, Kartal Dr. Lütfi Kırdar City Hospital, İstanbul, TURKEY
bClinic of Family Medicine, Kartal Dr. Lütfi Kırdar City Hospital, İstanbul, TURKEY
Turkiye Klinikleri J Intern Med. 2021;6(3):109-16
doi: 10.5336/intermed.2021-85192
Article Language: EN
Full Text
ABSTRACT
 Objective: We evaluated the effect of body weight reduction on serum irisin levels and analyzed the potential relationships of irisin with anthropometric and laboratory parameters. Material and Methods: The study included 42 females with median (2.5-97.5 percentiles) body mass index (BMI) of 38.3±5.5 kg/m2 who admitted to the obesity department and completed a 32 weeks weight reduction programme. Anthropometric and laboratory parameters were determined at the first intervention (T1) and after 8th and 32nd weeks (T2 and T3). Changes in parameters and relationships among irisin levels were evaluated. A preliminary analysis was also performed by dividing patients as metabolic syndrome positive and negative. Results: When compared with T1; BMI, waist and hip circumference, total cholesterol and triglyceride levels were significantly decreased at T2 and T3 (p<0.001) however, there was a significant decrease in body muscle mass, homeostatic model assessment-insulin resistance, HbA1c, and high density lipoprotein cholesterol levels only at T3. There was a significant difference between T1, T2 and T3 for hip circumference and body muscle mass in Kruskal-Wallis analysis (p=0.000 and 0.007 respectively). Although there was no significant change at irisin levels at T2, a significant increase was observed at T3 (p=0.007). There was no correlation between basal irisin levels and the anthropometric and laboratory parameters. There was no significant difference between metabolic syndrome positive and negative patients according to serum irisin levels. Conclusion: Body weight reduction caused a significant increase in irisin levels but there was no correlation between basal irisin levels and the anthropometric and laboratory parameters.

Keywords: Obesity, FNDC5 protein; human, insulin resistance, diet therapy
ÖZET
 Amaç: Bu çalışmada, vücut ağırlığı azalmasının, serum irisin seviyeleri üzerindeki etkisini değerlendirdik ve irisinin, antropometrik ve laboratuvar parametreleri ile potansiyel ilişkisini analiz ettik. Gereç ve Yöntemler: Çalışmaya, medyan (2,5-97,5 persentil) beden kitle indeksi (BKİ) 38,3±5,5 kg/m2 olan ve obezite bölümüne başvurup 32 haftalık zayıflama programını tamamlayan 42 kadın dâhil edildi. Antropometrik ve laboratuvar parametreleri, ilk müdahalede (T1) ve 8 ve 32. haftalarda (T2 ve T3) ölçüldü. Parametrelerdeki değişim ve irisin seviyeleri arasındaki ilişki değerlendirildi. Ayrıca metabolik sendrom pozitif ve negatif hastaları ayırarak ek bir analiz yapıldı. Bulgular: T1 ile karşılaştırıldığında; BKİ, bel ve kalça çevresi, total kolesterol ve trigliserid seviyeleri T2 ve T3'de anlamlı olarak azaldı (p<0,001); ancak vücut kas kütlesi, insülin direncinin homeostatik modeli değerlendirmesi, HbA1c ve yüksek yoğunluklu lipoprotein kolesterol seviyelerinde sadece T3'de anlamlı bir azalma oldu. Kruskal- Wallis analizlerinde kalça çevresi ve vücut kas kütlesi açısından T1, T2 ve T3 arasında anlamlı farklılık saptandı (sırasıyla p=0,000 ve 0,007). T2'de irisin seviyelerinde anlamlı bir değişiklik olmamasına rağmen T3'de anlamlı bir artış gözlendi (p=0,007). Bazal irisin seviyeleri ile antropometrik ve laboratuvar parametreleri arasında korelasyon saptanmadı. Metabolik sendrom pozitif ve negatif hastalar arasında serum irisin seviyeleri açısından anlamlı farklılık saptanmadı. Sonuç: Vücut ağırlığının azalması, irisin düzeylerinde önemli bir artışa neden oldu, ancak bazal irisin düzeyleri ile değerlendirilen antropometrik ve laboratuar parametrelerinin hiçbiri arasında ilişki saptanmadı.

Anahtar Kelimeler: Obezite, FNDC5 protein; insan,insülin direnci, diyet terapi
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