Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Effect of Nasal Steroid Treatment on Dry Eye in Geriatric Population with Rhinitis: Case Control Study
Riniti Olan Geriatrik Popülasyonda Nazal Steroid Tedavisinin Kuru Göz Üzerine Etkisi: Vaka Kontrol Çalışması
Esin KIRIKKAYAa, Engin BAŞERb
aDepartment of Ophthalmology, Health Sciences University İzmir Tepecik Training and Research Hospital, İzmir, TURKEY
bDepartment of Otorhinolaryngology, Health Sciences University İzmir Tepecik Training and Research Hospital, İzmir, TURKEY
Turkiye Klinikleri J Ophthalmol. 2021;30(4):218-26
doi: 10.5336/ophthal.2021-81852
Article Language: EN
Full Text
ABSTRACT
 Objective: To evaluate the effect of nasal steroid treatment on dry eye and rhinitis in the geriatric population presenting with both rhinitis and dry eye. Material and Methods: In this single-center clinical study 31 (62 eyes) older adults (age >65 years) with rhinitis and dry eye were included. The symptoms and findings of the patients were compared with the total nasal symptom score (TNSS), the ocular surface disease index (OSDI), Schirmer I test, and the tear break-up time (TBUT) before and after nasal steroid treatment (beclomethasone dipropionate), with a dose of 2×2 puff (50 μg) for 4 weeks. Intraocular pressure (IOP) values were also measured before and after treatment. All rhinitis cases (allergic and non-allergic) in the geriatric population were included in the study. Results: TNSS, OSDI score, and Schirmer and TBUT values improved significantly after nasal steroid treatment (beclomethasone dipropionate) (p<0.001). No significant change was detected in IOP values in the right or left eyes (p=0.608 and p=0.062, respectively). Conclusion: Nasal steroid treatment at the recommended doses can be effective for both rhinitis and dry eye symptoms without affecting the IOP in older adults, thus may reduce the need for multiple medications for dry eye symptoms. Our study should be supported with further studies designed in larger series.

Keywords: Dry eye; nasal steroid; older adults; rhinitis; Schirmer test
ÖZET
 Amaç: Bu çalışmanın amacı, riniti ve kuru gözü olan geriatrik popülasyonda nazal steroid tedavisinin kuru göz ve rinit üzerindeki etkisini değerlendirmektir. Gereç ve Yöntemler: Bu tek merkezli klinik çalışmaya riniti ve kuru gözü olan 31 (62 göz) yaşlı erişkin (yaş >65) dâhil edildi. Hastaların semptom ve bulguları; 4 hafta boyunca 2×2 puf (50 μg) dozunda nazal steroid (beklometazon dipropiyonat) kullanılarak, tedaviden önce ve sonra total nazal semptom skoru (TNSS), oküler yüzey hastalık indeksi (OYHİ), Schirmer I testi ve gözyaşı kırılma zamanı (GYKZ) değerlendirilerek karşılaştırıldı. Tedaviden önce ve sonra göz içi basıncı (GİB) değerleri de ölçüldü. Çalışmaya, geriatrik popülasyondaki tüm rinit olguları (alerjik ve nonalerjik) dâhil edildi. Bulgular: TNSS, OYHİ skoru, Schirmer ve GYKZ değerleri, nazal steroid (beklometazon dipropiyonat) tedavisinden sonra anlamlı derecede düzeldi (p<0,001). Sağ ve sol göz GİB değerlerinde anlamlı değişiklik saptanmadı (sırasıyla p=0,608; p=0,062). Sonuç: Önerilen dozlarda nazal steroid tedavisi; yaşlı erişkinlerde GİB'i etkilemeden, hem rinit hem de kuru göz semptomları için etkili olabilir, böylece kuru göz semptomları için birden fazla ilaca olan ihtiyacı azaltabilir. Çalışmamız, daha geniş serilerde tasarlanmış daha ileri çalışmalarla desteklenmelidir.

Anahtar Kelimeler: Kuru göz; nazal steroid; yaşlı erişkinler; rinit; Schirmer testi
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30.03.2014

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