Journal of Traditional Medical Complementary Therapies

.: REVIEW
Effects of Local Anesthetics on Viruses from a Neural Therapy Perspective
Nöral Terapi Perspektifinden Lokal Anesteziklerin Virüsler Üzerindeki Etkileri
Turgay ALTINBİLEKa, Rabia TERZİa, Elif KAYAa, Sadiye MURATb
aPrivate Office, İstanbul, TURKEY b Department of Physical Medicine and Rehabilitation, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, TURKEY
J Tradit Complem Med. 2021;4(3):394-9
doi: 10.5336/jtracom.2020-79906
Article Language: EN
Full Text
ABSTRACT
Viral infections have become one of the major health problems of today's world. Especially the current coronavirus disease2019 outbreak, causing systemic complications and mortality, has led to a serious pandemic worldwide. The disease has a wide clinical spectrum ranging from asymptomatic mild form to multiorgan failure and death. Although there is no treatment for coronavirus infection, some medications are used to suppress the inflammation. For this reason, the anti-inflammatory treatments have drawn attention to itself. Local anesthetics which are anti-inflammatory drugs have been effective in several steps on inflammatory cascade. In our daily practice, one of the treatment methods with local anesthetics is neural therapy which is special injection techniques (local, segmental, ganglion and interference area injections) and are applied to certain parts of the body for diagnosis, treat inflammatory diseases, pain and dysfunctions. With the local anesthetic usage, the autonomic nervous system is regulated via inhibition of abnormal stimuli transmitted by this system and controlling information pathways between cells. At the same time, the antiviral and anti-inflammatory effects of local anesthetics have been shown in various studies. It is considered that local anesthetics have anti-inflammatory effects by regulation of synthesis and release of anti-inflammatory mediators and antiviral effects by releasing of free radicals from lysozyme and inhibiting of membrane ATP-ase. In this review, we aimed to discuss the effects of local anesthetics and neural therapy on viral infections in the light of the literature and evaluate their possible beneficial effects on coronavirus infection.

Keywords: Neural therapy; local anesthetics; coronavirus; COVID-19
ÖZET
Viral enfeksiyonlar, günümüz dünyasının önemli sağlık sorunlarından biri hâline gelmiştir. Özellikle mevcut koronavirüs hastalığı2019 salgını, sistemik komplikasyonlara ve mortaliteye yol açarak, dünya genelinde ciddi bir pandemiye neden olmuştur. Hastalık, asemptomatik hafif formdan, çoklu organ yetersizliğine varan ve ölümle sonuçlanabilen geniş bir klinik spektruma sahiptir. Koronavirüs enfeksiyonunu tedavi edebilen bir ilaç henüz bulunmamakla beraber, tedavide kullanılan ilaçlar, inflamasyonu baskılamaya yöneliktir. Bu nedenle de inflamasyona karşı kullanılan tedaviler dikkat çekmektedir. Lokal anestezikler, inflamatuar kaskad üzerindeki birçok adımda etkili antiinflamatuar ilaçlardan biridir. Günlük pratiğimizde, lokal anesteziklerin kullanıldığı tedavilerden biri nöral terapidir. Nöral terapi, inflamatuar hastalıklar, ağrı ve fonksiyon bozukluklarının teşhis ve tedavisi amacıyla vücudun belirli bölgelerine, özel enjeksiyon tekniklerinin uygulandığı (lokal, segmental, ganglion ve bozucu alan enjeksiyonları), bir tedavi yöntemidir. Nöral terapide kullanılan lokal anestezik uygulamalarıyla otonom sinir sistemi tarafından iletilen anormal uyarılar önlenir, hücreler arası bilgi alışverişi kontrol edilir ve böylece otonom sinir sisteminin regülasyonu sağlanmış olur. Aynı zamanda nöral terapide, uzun yıllardır güvenle kullanılan lokal anesteziklerin antiviral ve antiinflamatuar etkileri çeşitli çalışmalarda gösterilmiştir. Lokal anesteziklerin, antiinflamatuar mediyatörlerin sentez ve salınımını etkileyerek, antiinflamatuar etkiyi, lizozim ile serbest radikallerin salınımı ve membran ATP az inhibisyonuyla antiviral etkiyi gerçekleştirdiği düşünülmektedir. Bu derlemede lokal anesteziklerin ve nöral tedavinin, virüs enfeksiyonları üzerindeki etkilerininin literatür ışığında tartışılması ve koronavirüs enfeksiyonu üzerindeki olası yararlı etkilerinin değerlendirilmesi amaçlanmıştır.

Anahtar Kelimeler: Nöral terapi; lokal anestezik; koronavirüs; COVID-19
REFERENCES:
  1. Chilvers MA, McKean M, Rutman A, Myint BS, Silverman M, O'Callaghan C, et al. The effects of coronavirus on human nasal ciliated respiratory epithelium. Eur Respir J. 2001;18(6):965-70. [Crossref]  [PubMed] 
  2. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al; China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;20;382(8):727-33. [Crossref]  [PubMed]  [PMC] 
  3. Conti P, Ronconi G, Caraffa A, Gallenga CE, Ross R, Frydas I, et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020;34(2):327-31. [PubMed] 
  4. Conti P, Gallenga CE, Tetè G, Caraffa A, Ronconi G, Younes A, et al. How to reduce the likelihood of coronavirus-19 (CoV-19 or SARS-CoV-2) infection and lung inflammation mediated by IL-1. J Biol Regul Homeost Agents. 2020;34(2):333-8. [PubMed] 
  5. Weinschenk S. Neural therapy. A review of the therapeutic use of local anesthetics. Acupuncture and Related Therapies. 2012;1(1):5-9. [Crossref] 
  6. Brobyn TL, Chung MK, LaRiccia PJ. Neural therapy: an overlooked game changer for patients suffering chronic pain? J Pain Relief. 2015;4(3):1-4. [Link] 
  7. Klinghardt DK. Neuraltherapy. J Neurol Orthop Med Surg. 1993;14(2):109-14. [Link] 
  8. Dosch P, Dosch M. Chronological survey. Manual of Neural Therapy According to Huneke. 2nd ed. Stuttgart: Thieme; 2007. p.5. [Crossref] 
  9. Poste G, Reeve P. Inhibition of virus-induced cell fusion by local anaesthetics and phenothiazine tranquilizers. J Gen Virol. 1972;16(1):21-8. [Crossref]  [PubMed] 
  10. Cassuto J, Sinclair R, Bonderovic M. Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand. 2006;50(3):265-82. [Crossref]  [PubMed] 
  11. Sasagawa S. Inhibitory effects of local anesthetics on migration, extracellular release of lysosomal enzyme, and superoxide anion production in human polymorphonuclear leukocytes. Immunopharmacol Immunotoxicol. 1991;13(4):607-22. [Crossref]  [PubMed] 
  12. Kiefer RT, Ploppa A, Krueger WA, Plank M, Nohé B, Haeberle HA, et al. Local anesthetics impair human granulocyte phagocytosis activity, oxidative burst, and CD11b expression in response to Staphylococcus aureus. Anesthesiology. 2003;98(4):842-8. [Crossref]  [PubMed] 
  13. Kutchai H, Geddis LM. Inhibition of the Na, K-ATPase of canine renal medulla by several local anesthetics. Pharmacol Res. 2001;43(4):399-403. [Crossref]  [PubMed] 
  14. Dosch P, Dosch M. Infectious diseases. Manual of Neural Therapy According to Huneke. 2nd ed. Stuttgart: Thieme; 2007. p.186. [Crossref] 
  15. Johnson SM, Saint John BE, Dine AP. Local anesthetics as antimicrobial agents: a review. Surg Infect (Larchmt). 2008;9(2):205-13. [Crossref]  [PubMed] 
  16. Edens HA, Parkos CA. Neutrophil transendothelial migration and alteration in vascular permeability: focus on neutrophil-derived azurocidin. Curr Opin Hematol. 2003;10(1):25-30. [Crossref]  [PubMed] 
  17. Lan W, Harmon DC, Wang JH, Shorten GD, Redmond PH. Activated endothelial interleukin-1beta, -6, and -8 concentrations and intercellular adhesion molecule-1 expression are attenuated by lidocaine. Anesth Analg. 2005;100(2):409-12. [Crossref]  [PubMed] 
  18. Kownatzki E, Uhrich S. Enhancement of chemotactic migration by the local anesthetic tetracaine. Immunobiology. 1983;165(1):97-106. [Crossref]  [PubMed] 
  19. Fischer LG, Bremer M, Coleman EJ, Conrad B, Krumm B, Gross A, et al. Local anesthetics attenuate lysophosphatidic acid-induced priming in human neutrophils. Anesth Analg. 2001;92(4):1041-7. [Crossref]  [PubMed] 
  20. Paul H, Clayburne G, Schumacher HR. Lidocaine inhibits leukocyte migration and phagocytosis in monosodium urate crystal-induced synovitis in dogs. J Rheumatol. 1983;10(3):434-9. [PubMed] 
  21. Tsuda Y, Mashimo T, Yoshiya I, Kaseda K, Harada Y, Yanagida T, et al. Direct inhibition of the actomyosin motility by local anesthetics in vitro. Biophys J. 1996;71(5):2733-41. [Crossref]  [PubMed]  [PMC] 
  22. Kunze H, Nahas N, Traynor JR, Wurl M. Effects of local anaesthetics on phospholipases. Biochim Biophys Acta. 1976;20;441(1):93-102. [Crossref]  [PubMed] 
  23. Yregård L, Löwhagen PH, Cassuto J, Nilsson U, Lindblom L, Räntfors J, et al. A new technique for the analysis of endogenous mediators released following thermal injury. Burns. 2001;27(1):9-16. [Crossref]  [PubMed] 
  24. Goel RK, Tavares IA, Nellgard P, Jonsson A, Cassuto J, Bennett A, et al. Effect of lignocaine on eicosanoid synthesis by pieces of human gastric mucosa. J Pharm Pharmacol. 1994;46(4):319-20. [Crossref]  [PubMed] 
  25. Yregård L, Cassuto J, Tarnow P, Nilsson U. Influence of local anaesthetics on inflammatory activity postburn. Burns. 2003;29(4):335-41. [Crossref]  [PubMed] 
  26. Kazimierczak W, Peret M, Maśliński C. The action of local anaesthetics on histamine release. Biochem Pharmacol. 1976;1;25(15):1747-50. [Crossref]  [PubMed] 
  27. Cullen BF, Haschke RH. Local anesthetic inhibition of phagocytosis and metabolism of human leukocytes. Anesthesiology. 1974;40(2):142-6. [Crossref]  [PubMed] 
  28. Sinclair R, Eriksson AS, Gretzer C, Cassuto J, Thomsen P. Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro. Acta Anaesthesiol Scand. 1993;37(2):159-65. [Crossref]  [PubMed] 
  29. Takao Y, Mikawa K, Nishina K, Maekawa N, Obara H. Lidocaine attenuates hyperoxic lung injury in rabbits. Acta Anaesthesiol Scand. 1996;40(3):318-25. [Crossref]  [PubMed] 
  30. Nellgård P, Jönsson A, Bojö L, Tarnow P, Cassuto J. Small-bowel obstruction and the effects of lidocaine, atropine and hexamethonium on inflammation and fluid losses. Acta Anaesthesiol Scand. 1996;40(3):287-92. [Crossref]  [PubMed] 
  31. Cassuto J, Nellgård P, Stage L, Jönsson A. Amide local anesthetics reduce albumin extravasation in burn injuries. Anesthesiology. 1990;72(2):302-7. [Crossref]  [PubMed] 
  32. Nishina K, Mikawa K, Maekawa N, Takao Y, Obara H. Does early posttreatment with lidocaine attenuate endotoxin-induced acute injury in rabbits? Anesthesiology. 1995;83(1):169-77. [Crossref]  [PubMed] 
  33. Nishina K, Mikawa K, Takao Y, Shiga M, Maekawa N, Obara H, et al. Intravenous lidocaine attenuates acute lung injury induced by hydrochloric acid aspiration in rabbits. Anesthesiology. 1998;88(5):1300-9. [Crossref]  [PubMed] 
  34. Azoulay E, Herigault S, Levame M, Brochard L, Schlemmer B, Harf A, et al. Effect of granulocyte colony-stimulating factor on bleomycin-induced acute lung injury and pulmonary fibrosis. Crit Care Med. 2003;31(5):1442-8. [Crossref]  [PubMed] 
  35. Das KC, Misra HP. Prevention of reperfusion lung injury by lidocaine in isolated rat lung ventilated with higher oxygen levels. J Postgrad Med. 2003;49(1):17-20. [Crossref]  [PubMed] 
  36. Harris GR. Wonder why? Effective treatment of chronic pain by the integration of neural therapy and prolotherapy. Journal of Prolotherapy. 2010;2(2):377-86. [Link] 
  37. Mak PH, Irwin MG, Tsui SL. Functional improvement after physiotherapy with a continuous infusion of local anaesthetics in patients with complex regional pain syndrome. Acta Anaesthesiol Scand. 2003;47(1):94-7. [Crossref]  [PubMed] 
  38. Hey M, Wilson I, Johnson MI. [Stellate ganglion blockade (SGB) for refractory index finger pain - a case report]. Ann Phys Rehabil Med. 2011;54(3):181-8. [Crossref]  [PubMed] 
  39. Kaczmarek DJ, Herzog C, Larmann J, Gillmann HJ, Hildebrand R, Schmitz M, et al. Lidocaine protects from myocardial damage due to ischemia and reperfusion in mice by its antiapoptotic effects. Anesthesiology. 2009;110(5):1041-9. [Crossref]  [PubMed] 
  40. Dosch P, Dosch M. Fewer. Manual of Neural Therapy According to Huneke. 2nd ed. Stuttgart: Thieme; 2007. p.170. [Crossref] 
  41. Dosch MP. Atlas of Neural Therapy With Local Anesthetics. 3rd ed. Munich: Thieme; p.194.
  42. Oettmeier R, Reuter U, Bonilla LBP. The procaine-base-infusion: 20 years of experience of an alternative use with several therapeutical effects. J Altern Complement Integr Med. 2019;5:61. [Crossref] 
  43. Dosch P, Dosch M. Immune deficiency. Manual of Neural Therapy According to Huneke. 2nd ed. Stuttgart: Thieme; 2007. p.185. [Crossref] 
  44. Dosch P, Dosch M. Segmental zones of individual organs. Manual of Neural Therapy According to Huneke. 2nd ed. Stuttgart: Thieme; 2007. p.75. [Crossref] 
  45. World Health Organization. [Internet]. Coronavirus disease (COVID-19) pandemic. WHO ©2021.(Erişim tarihi: Sept. 16, 2020). Available from: [Link] 
  46. Li G, De Clercq E. Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020;19(3):149-50. [Crossref]  [PubMed] 

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