Turkiye Klinikleri Journal of Medical Sciences

.: REVIEW
ESX-1, ESX-3 ve ESX-5 Salgı Sistemleri ve Mycobacterium Tuberculosis
ESX-1, ESX-3 and ESX-5 Secretory Systems and Mycobacterium Tuberculosis
Gülşah TOLLUa
aMersin Üniversitesi Teknik Bilimler Meslek Yüksekokulu, Veterinerlik Bölümü, Mersin, TÜRKİYE
Turkiye Klinikleri J Med Sci. 2020;40(3):375-81
doi: 10.5336/medsci.2020-74818
Article Language: TR
Full Text
ÖZET
 Tüberküloz (TB) ile mücadele, günümüz global halk sağlığı önceliklerinden biridir. Mycobacterium tuberculosis (Mtb) en önemli bakteriyel patojenlerden biridir; bu patojen dünya nüfusunun neredeyse %30'unu enfekte ederek, birçok kişinin ölümüne neden olmaktadır. Mtb basilleri büyüme, sağkalım ve virülansta, membranlardan bakteri yüzeyine ve çevreye kompleks hücre duvarı boyunca bir dizi protein efekti ihraç eden eşsiz salgı sistemleri kullanırlar. Patojenik Mtb'nin 5 paralog ESX salgılama sistemi vardır; bunlar ESX-1 ile ESX-5 arasındadır. ESX salgılama sistemleri diğer birçok aktinobakteriyel, grampozitif bakteride bulunur ve son zamanlarda tip VII salgılama sistemleri [type VII secrection system (T7SS)] olarak adlandırılmaları önerilmiştir. T7SS tarafından, konakçı hücrelere salgılanan proteinler Mtb ile ilişkili virülansta aracı bir rol oynar; bu durum, bu sistemi gelecekteki ilaç ve aşı gelişimi için aday yapar. Bununla birlikte, T7SS'ye dâhil olan bileşenlerin birçoğu tanımlanmış olsa da hem iç hem de dış mikobakteriyel zarlar boyunca translokasyon mekanizması büyük ölçüde açıklanamamıştır. Yapılan tüm çalışmalar incelendiğinde, ESX sistemlerinin mikobakterilerde protein sekresyonunun lokalizasyonunu yöneten, daha önce görülmemiş mekanizmalar oldukları öngörülmektedir. T7SS'nin temel rolünü anlamak, acilen ihtiyaç duyulan yeni potansiyel terapötik hedefleri ve tüberkülozu tedavi etmek için yeni müdahale stratejileri geliştirilmesini sağlayabilir.

Anahtar Kelimeler: ESX-1; ESX-3; ESX-5; tüberküloz; tip VII salgı sistemi
ABSTRACT
 Combating tuberculosis (TB) is one of the current global public health priorities. Mycobacterium tuberculosis (Mtb) is one of the most important bacterial pathogens; this pathogen infects almost 30% of the world's population, causing the death of many. Mtb bacilli use unique secretion systems that export a range of protein effects across the complex cell wall, from membranes to the bacterial surface and the environment, in growth, survival and virulence. The pathogenic Mtb has 5 paralogous ESX secretion systems, which range from ESX1 to ESX-5. ESX secretory systems are found in many other actinobacteria, gram-positive bacteria and have recently been referred to as type VII secretion systems (T7SS). Proteins secreted by T7SS into host cells play a mediating role in Mtb-related virulence, making this system a candidate for future drug and vaccine development.. However, although many of the components included in T7SS have been identified, the mechanism of translocation across both internal and external mycobacterial membranes has not been largely explained. When all studies are examined, it is seen that ESX systems are unprecedented mechanisms that govern the localization of protein secretion in mycobacteria. Understanding the basic role of T7SS can lead to the development of new potential therapeutic targets and new intervention strategies to treat tuberculosis.

Keywords: ESX-1; ESX-3; ESX-5; tuberculosis; type VII secretion system
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"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com