Turkiye Klinikleri Journal of Anesthesiology Reanimation

.: ORIGINAL RESEARCH
Features and Predictors of Mortality in Geriatric COVID-19 Patients in Intensive Care Unit: Retrospective Clinical Study
Yoğun Bakım Ünitesindeki Geriatrik COVID-19 Hastalarının Özellikleri ve Mortalite Prodüktörleri: Retrospektif Klinik Çalışma
Behiye Deniz KOSOVALIa, Gül Meral KOCABEYOĞLUa, Özlem Balkız SOYALb, Nevzat Mehmet MUTLUa
aClinic of Critical Care, Ankara City Hospital, Ankara, Türkiye
bClinic of Anesthesiology and Reanimation, Ankara City Hospital, Ankara, Türkiye
Turkiye Klinikleri J Anest Reanim. 2022;20(2):43-51
doi: 10.5336/anesthe.2021-86745
Article Language: EN
Full Text
ABSTRACT
Objective: Although coronavirus disease-2019 (COVID- 19) is seen in all age groups, the disease may progress more severely in adults with geriatric patients and comorbidities. We aimed to determine mortality rates and factors that may affect mortality by comparing the demographic, clinical, laboratory and radiological characteristics of different geriatric age groups. Material and Methods: A total of 444 COVID-19 intensive care unit (ICU) patients aged ≥65 years who were diagnosed with COVID-19 (real-time polymerase chain reaction positive) were included in the study. The patients were classified into 3 groups according to their age: younger-aged (65-74 years old), middle-aged (75-84 years old) and advanced-aged (≥85 years old) and the groups were compared. Results: The most common hospital admission symptom of total of 444 (73.2%) patients was dyspnoea. There was a statistical difference between genders in three groups (p<0.001). There was no difference between the mortality rates of the 3 groups (p=0.097). According to multiple logistic regression analysis, age ≥85 years, lactate dehydrogenase (LDH), procalcitonin and myalgia/joint pain were determined to be the risk factors that may affect mortality (p values 0.01, 0.025, 0.033 and 0.01, respectively). Conclusion: In geriatric COVID-19 ICU patients, advanced-age (≥85 years), male gender, laboratory parameters (e.g., interleukin-6, ferritin, procalcitonin, LDH) and, dyspnoea are the risk factors that increased mortality. Mortality rate was similar in geriatric groups.

Keywords: Geriatry; COVID-19; intensive care unit; mortality
ÖZET
Amaç: Koronavirüs hastalığı-2019 [coronavirus disease-2019 (COVID-19)], tüm yaş gruplarında görülse de ileri yaş ve komorbiditeleri olan erişkinlerde hastalık daha ağır seyredebilir. Farklı geriatrik yaş gruplarının demografik, klinik, laboratuvar ve radyolojik özelliklerini karşılaştırarak, mortalite oranlarını ve mortaliteyi etkileyebilecek faktörleri belirlemeyi amaçladık. Gereç ve Yöntemler: Çalışmaya, COVID-19 (gerçek zamanlı polimeraz zincir reaksiyonu pozitif) tanısı almış 65 yaş ve üzeri 444 COVID-19 yoğun bakım ünitesi (YBÜ) hastası dâhil edildi. Hastalar yaşlarına göre genç yaşlı (65-74), orta yaşlı (75-84) ve ileri yaşlı (≥85) olmak üzere 3 gruba ayrıldı ve gruplar karşılaştırıldı. Bulgular: Toplam 444 hastanın en sık hastaneye başvuru semptomu dispne (%73,2) idi. Üç grup arasında cinsiyetler açısından istatistiksel fark vardı (p<0,001). Üç grubun ölüm oranları arasında fark yoktu (p=0,097). Çoklu lojistik regresyon analizine göre yaş ≥85, laktat dehidrogenaz (LDH), prokalsitonin ve miyalji/eklem ağrısı mortaliteyi etkileyebilecek risk faktörleri olarak belirlendi (p değerleri sırasıyla 0,01, 0,025, 0,033 ve 0,01). Sonuç: Geriatrik COVID-19 YBÜ'de ileri yaş (≥85), erkek cinsiyet, laboratuvar parametreleri (örneğin interlökin-6, ferritin, prokalsitonin, LDH) ve dispne mortaliteyi artıran risk faktörleridir. Mortalite oranı geriatri gruplarda benzerdi.

Anahtar Kelimeler: Geriatri; COVID-19; yoğun bakım ünitesi; ölüm
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