Turkiye Klinikleri Journal of Veterinary Sciences

.: ORIGINAL RESEARCH
Giardia duodenalis ile Enfekte Buzağılarda Ayuverdik Bitki Olan Kurkumin ile Enema Sağaltımı: Kohort Araştırma
Enema Treatment with the Ayuvedic Herb Curcumin in Calves Infected with Giardia duodenalis: Cohort Study
Kerem URALa, Hasan ERDOĞANa, Deniz ALIÇ URALb, Serdar PAŞAa, Songül ERDOĞANa, Adnan AYANc, Mehmet GÜLTEKİNa
aAydın Adnan Menderes Üniversitesi, Veteriner Fakültesi, İç Hastalıkları ABD, Aydın, Türkiye
bAydın Adnan Menderes Üniversitesi, Veteriner Fakültesi, Fakülte Çiftliği, Aydın, Türkiye
cVan Yüzüncü Yıl Üniversitesi, Veteriner Fakültesi, Genetik Bölümü, Van, Türkiye
Turkiye Klinikleri J Vet Sci. 2022;13(2):35-45
doi: 10.5336/vetsci.2022-92128
Article Language: TR
Full Text
ÖZET
 Amaç: Farklı birçok hastalıkta giderek artan kurkumin kullanımına dair veriler göz önüne alındığında, bu saha çalışmasının amacı, giyardiyazisli buzağılarda enema (proktolizis) ile kurkuminin terapötik etkinliğinin araştırılmasıdır. Gereç ve Yöntemler: Çalışmaya her iki cinsiyette olan, 27-60 günlük yaştaki Giardia duodenalis ile doğal enfekte buzağılar dâhil edildi. Tanı: a) Hızlı ELISA test kiti, b) Mikroskobik ve öncelikli parazitolojik kontrol, c) Asemblaj tayiniyle birlikte Nested Polimeraz Zincir Reaksiyonu analiziyle yapıldı. Giyardiyazisli ve ishalli buzağılar Grup I (2 g/buzağı/gün kurkumin, rektal yolla, 10 gün süreyle) ya da Grup II (herhangi bir ilaç uygulaması yapılmayana kontrol) olmak üzere rastgele 2 gruba ayrıldı. Enema kurkuminin terapötik etkinliği 0., 3., 7. ve 10. günlerde rektal yoldan toplanan dışkı örneklerinin mikroskobik incelemesiyle belirlendi. Bulgular: Gruplar arası kontrol ve sağaltım karşılaştırması 3, 7 ve 10. günlerdeki %58,17 (p=0,125), %99,68 (p=0,001) ve %100 (p=0,001) azalma şeklinde görüldü. Kurkumin enema hiçbir yan etki olmaksızın güvenle uygulanmıştır. Sonuç: Sonuç olarak buzağılarda giyardiyazis sağaltımında enema kurkuminin kullanımının güvenli, kolay ve ekonomik (makul fiyatlanan ve ucuz) olduğu sonucuna varmak yanlış olmayacaktır. Saha uygulamasındaki bu doz rejimi (bu çalışmada model olarak enema kullanıldı) zorlayıcı olmayıp diğer doz planlaması ilerleyen çalışmamızın amacı olacaktır. Enema modeliyle kurkumin kullanımının giyardiyazisli buzağılardaki antiparazitik etkinliği ile kist saçılımında belirgin azalma sağladığı öne sürülebilinir.

Anahtar Kelimeler: Buzağı; giyardiyazis; kurkumin; zerdeçal
ABSTRACT
 Objective: Given the growing cumulative evidence of curcumin usage for several diseases, the purpose of this field study was to detect the therapeutic efficacy of curcumin enema (proctolysis) in calves with giardiasis. Material and Methods: A total of 20 calves naturally infected with Giardia duodenalis at the age of 27 to 60 days, of both sexes were enrolled into the study. The diagnosis was based on a) Rapid diagnostic ELISA test kits, b) Microscopic and prior parasitological check and c) Nested Polymerase Chain Reaction analysis along with assemblage detection. Calves with diarrhea and giardiasis were randomly assigned into 2 groups (n=10), Group I (2 g/calf/day curcumin via rectal route for 10 days) and Group II (were stable as the control without any drug prescription). The therapeutic efficacy of curcumin enema was determined by microscopical examination of faecal samples collected rectally on days 0, 3, 7 and 10. Results: Intra-group comparison of control and treatment calves revealed 58.17% (p=0.125), 99.68% (p=0.001) and 100% (p=0.001) reduction on days 3, 7, and 10, respectively. Curcumin enema was safely used without any side effects. Conclusion: In conclusion, it should not be unwise to draw conclusion that curcumin enema could be safely, easily and economically (reasonably priced and cheap) used for the treatment of giardiasis among calves. At this dose regimen field application (enema used as a model in this study) was not compelling, in which other dose scheduling should be the aim of our next study. The enema model suggested that curcumin prescription caused effective reduction in cyst excretion with antiparasitic efficacy among calves giardiasis.

Keywords: Calves; giardiasis; curcumin; turmeric
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