Turkiye Klinikleri Journal of Internal Medicine

.: ORIGINAL RESEARCH
Güneşe Maruziyet Azlığı ile Primer Hiperparatiroidizm İlişkisi: Retrospektif Gözlemsel Bir Çalışma
The Association of Less Sun Exposure and Primary Hyperparathyroidism: A Retrospective Observational Study
Dilek GENEŞa, Mehmet ŞİMŞEKb, Zafer PEKKOLAYa, Alpaslan Kemal TUZCUa
aDicle Üniversitesi Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları BD, Diyarbakır, Türkiye
aSağlık Bilimleri Üniversitesi Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Endokrinoloji ve Metabolizma Hastalıkları Kliniği, Diyarbakır, Türkiye
Turkiye Klinikleri J Intern Med. 2022;7(2/3):51-5
doi: 10.5336/intermed.2022-91858
Article Language: TR
Full Text
ÖZET
 Amaç: Toplumumuzun bir bölümünde inançları gereği insanlar baş ve ekstremitelerin kapalı olduğu giysiler tercih etmektedir. Bu çalışmada, primer hiperparatiroidizm (PHPT) tanısı olanlarda güneş ışınlarına maruziyet ile D vitamini (DV) arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntemler: Haziran 2014-Ağustos 2021 tarihleri arasında Dicle Üniversitesi Tıp Fakültesi Erişkin Endokrin Birimine başvuran ve PHPT tanısı konulan hastaların DV düzeyleri kaydedildi. Bu kişiler, baş ve ekstremitelerin güneşe olan maruziyet durumuna göre gruplara ayrılarak kategorize edildi. Gruplar; paratiroid hormon (PTH), 25-hidroksivitamin D, kalsiyum, fosfor, tiroid hormonları ile diğer biyokimyasal parametreler uygun istatistiksel yöntemler kullanılarak karşılaştırıldı. Bulgular: Toplam 76 kişinin 66'sı (%86,8) kadın, 10'u (%13,2) erkek idi. Bunlar içerisinde Grup 1'de güneşe maruziyeti olan 18 (%23,7) kişinin yaş ortalaması 40,2±13,1 (yıl), Grup 2'de güneşe maruziyeti az olan 58 (%76,3) kişinin yaşları ortalaması ise 52,6±12,3 (yıl) idi. Güneşe maruziyeti az olanların tamamı kadın iken güneşe maruziyetin olduğu grubun 10'u (%55,6) erkek, 8'i (%44,4) kadın idi. PHPT tanısı olan hastalarda DV düzeyleri <30 ng/mL olanların oranı %89,7, 20-29 ng/mL olanların oranı %10,3, <20 ng/mL olanların oranı %79,4, <10 ng/mL olanların oranı ise %42,6 bulundu. Gruplar arasında DV düzeyleri açısından farklılık yoktu (p: 0,156). Sonuç: PHPT olan hastalarda güneşe maruziyet bakımından DV düzeylerinde anlamlı fark bulunmadı ancak güneşe maruziyetin az olduğu grupta daha yüksek PTH ve daha düşük DV düzeylerinin olduğu gözlendi.

Anahtar Kelimeler: Primer hiperparatiroidizm; vitamin D eksikliği; 25-hidroksivitamin D
ABSTRACT
 Objective: In a part of our society, people prefer clothes that cover the head and extremities due to their beliefs. In this study, we aimed to investigate the relationship between exposure to sunlight and vitamin D (VD) in patients with primary hyperparathyroidism (PHPT). Material and Methods: The VD levels of the patients diagnosed with PHPT who applied to the adult Endocrine Unit of Dicle University Faculty of Medicine between June 2014 and August 2021 were recorded. These individuals were categorized according to the sun exposure of the head and extremities. The groups; parathyroid hormone (PTH), 25- hydroxyvitamin D, calcium, phosphorus, thyroid hormones and other biochemical parameters were compared using appropriate statistical methods. Results: Of the 76 people, 66 (86.8%) were female and 10 (13.2%) were male. Among these, the mean age of 18 people (23.7%) with sun exposure in Group 1 was 40.2±13.1 (years), and the mean age of 58 people (76.3%) with low sun exposure in Group 2 was 52.6±12.3 (years). All of those with less exposure to the sun were women; Ten (55.6%) of the group with sun exposure were male and 8 (44.4%) were female. In patients diagnosed with PHPT, the rate of VD levels <30 ng/mL was 89.7%, the rate of 20-29 ng/mL was 10.3%, the rate of <20 ng/mL was 79.4%, and the rate of <10 ng/mL was 42.6%. There was no difference between the groups in terms of VD levels (p: 0.156). Conclusion: There was no significant difference in VD levels in terms of sun exposure in patients with PHPT; but higher PTH and lower VD levels were observed in the group with less sun exposure.

Keywords: Primary hyperparathyroidism; vitamin D deficiency; 25-hydroxyvitamin D
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