Turkiye Klinikleri Journal of Anesthesiology Reanimation

.: REVIEW
Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu
The Neglected Consequences of Critical Illness Survivors: Post-Intensive Care Syndrome
Öznur ERBAY DALLIa, Nermin KELEBEK GİRGİNa, Ferda KAHVECİa
aBursa Uludağ Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon ABD, Yoğun Bakım BD, Bursa, TÜRKİYE
Turkiye Klinikleri J Anest Reanim. 2021;19(1):36-45
doi: 10.5336/anesthe.2020-80057
Article Language: TR
Full Text
ÖZET
Her yıl milyonlarca hasta, yoğun bakıma kabul edilmekte ve bunların 1/3'ü mekanik ventilatöre ihtiyaç duymaktadır. Durumu kritik derecede olan bu bireyler, hastalıklar, yaralanmalar, ventilatörler veya diğer tedaviler nedeniyle çeşitli sağlık sorunları yaşayabilmektedir. Bu tür sorunlar, yoğun bakım izlemi süresince tehlikeli süreç atlatılsa da her zaman tamamen ortadan kaldırılamayabilir ve bireyin taburculuk sonrası yaşamında da devam edebilir. Yoğun bakım sonrası sendromu; yoğun bakımda yatış sırasında ve taburcu olduktan sonra hastalarda ortaya çıkan fiziksel, bilişsel ve mental bozukluklar ile uzun vadeli prognozu ifade eder. Bu durum, ayrıca hastaların ailelerinde de mental olarak ortaya çıkabilmektedir. Yoğun bakımda kalan hastaların yarısından fazlası, sendrom sonucu ortaya çıkan bozukluklardan en az birine sahip olmaktadır. Bu durum, kritik hastalık sonrası hayatta kalan bireylerin yaşamını ciddi olarak etkilemekte ve hastalar güçsüzlük, kas kaybı, dikkat eksikliği, hafıza kaybı, anksiyete, depresyon gibi birçok problemle karşı karşıya kalmaktadır. Bu tür olumsuzlukların önlenmesi için yoğun bakım sonrası sendromunun, multidisipliner ekip anlayışı çerçevesinde değerlendirilmesi ve önlemeye yönelik stratejilerin benimsenmesi kritik rol oynamaktadır. Sendrom, günümüz yoğun bakım tıbbı ve alandaki sağlık profesyonelleri tarafından göz ardı edilmemesi ve önemsenmesi gereken hedefler içinde yerini almalıdır. Bu derlemede sendromun oluşumu, risk faktörleri ve önleme stratejileri tartışılarak, yoğun bakım alanında sıklıkla ihmal edilen bir konuya ışık tutmak ve sağlık profesyonellerinin farkındalığını artırmak amaçlanmaktadır.

Anahtar Kelimeler: Yoğun bakım; kritik hastalık
ABSTRACT
Millions of patients are admitted to intensive care every year, and one third of these require a mechanical ventilator. These critically ill individuals may experience various health problems due to illnesses, injuries, ventilators or other treatments. Even though the dangerous process is overcome during intensive care follow-up, such problems may not always be completely eliminated and may continue in the life of the individual after discharge. Post-intensive care syndrome refers to the long-term prognosis of patients as well as physical, cognitive and mental disorders that occur during hospitalization in intensive care and after discharge. This situation can also occur in families of patients. More than half of the patients staying in the intensive care unit have at least one of the disorders resulting from the syndrome. This situation seriously affects the lives of individuals who survive critical illness and patients face many problems such as weakness, muscle wasting, attention deficit, memory loss, anxiety and depression. Evaluation of post-intensive care syndrome within the framework of a multidisciplinary team understanding and adoption of prevention strategies play a critical role in preventing such adversities. The syndrome should be among the goals that should not be ignored and considered by today's intensive care medicine and health professionals in the field. In this review, the formation of the syndrome, risk factors and prevention strategies are discussed, aimed to shed light on this frequently neglected issue in the intensive care field and to increase the awareness of health professionals.

Keywords: Critical care; critical illness
REFERENCES:
  1. Harvey MA, Davidson JE. Postintensive care syndrome: right care, right now?and later. Crit Care Med. 2016;44(2):381-5.[Crossref] [PubMed] 
  2. Rawal G, Yadav S, Kumar R. Post-intensive care syndrome: an overview. J Transl Int Med. 2017;30;5(2):90-2.[Crossref] [PubMed] [PMC] 
  3. Colbenson GA, Johnson A, Wilson ME. Post-intensive care syndrome: impact, prevention, and management. Breathe (Sheff). 2019;15(2):98-101.[Crossref] [PubMed] [PMC] 
  4. Inoue S, Hatakeyama J, Kondo Y, Hifumi T, Sakuramoto H, Kawasaki T, et al. Post-intensive care syndrome: its pathophysiology, prevention, and future directions. Acute Med Surg. 2019;25;6(3):233-46.[Crossref] [PubMed] [PMC] 
  5. Needham DM, Davidson J, Cohen H, Hopkins RO, Weinert C, Wunsch H, et al. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med. 2012;40(2):502-9.[Crossref] [PubMed] 
  6. Brown SM, Bose S, Banner-Goodspeed V, Beesley SJ, Dinglas VD, Hopkins RO, et al; Addressing Post Intensive Care Syndrome 01 (APICS-01) study team. Approaches to addressing post-ıntensive care syndrome among ıntensive care unit survivors. A narrative review. Ann Am Thorac Soc. 2019;16(8):947-56.[Crossref] [PubMed] 
  7. Davidson JE, Harvey MA. Patient and family post-ıntensive care syndrome. AACN Adv Crit Care. 2016;27(2):184-6.[Crossref] [PubMed] 
  8. Wunsch H, Angus DC, Harrison DA, Collange O, Fowler R, Hoste EA, et al. Variation in critical care services across North America and Western Europe. Crit Care Med. 2008;36(10): 2787-93,e1-9.[Crossref] [PubMed] 
  9. Kosinski S, Mohammad RA, Pitcher M, Haezebrouck E, Coe AB, Costa DK, et al. What Is post-intensive care syndrome (PICS)? Am J Respir Crit Care Med. 2020;15;201(8): P15-P6.[Crossref] [PubMed] 
  10. Daniels LM, Johnson AB, Cornelius PJ, Bowron C, Lehnertz A, Moore M, et al. Improving quality of life in patients at risk for post-intensive care syndrome. Mayo Clin Proc Innov Qual Outcomes. 2018;2(4):359-69.[Crossref] [PubMed] [PMC] 
  11. Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, et al; BRAIN-ICU Study Investigators. Long-term cognitive impairment after critical illness. N Engl J Med. 2013;3;369(14):1306-16.[Crossref] [PubMed] [PMC] 
  12. Maley JH, Brewster I, Mayoral I, Siruckova R, Adams S, McGraw KA, et al. Resilience in survivors of critical illness in the context of the survivors' experience and recovery. Ann Am Thorac Soc. 2016;13(8):1351-60.[Crossref] [PubMed] [PMC] 
  13. Marra A, Pandharipande PP, Girard TD, Patel MB, Hughes CG, Jackson JC, et al. Co-occurrence of post-intensive care syndrome problems among 406 survivors of critical illness. Crit Care Med. 2018;46(9):1393-1401.[Crossref] [PubMed] [PMC] 
  14. Elliott D, Davidson JE, Harvey MA, Bemis-Dougherty A, Hopkins RO, Iwashyna TJ, et al. Exploring the scope of post-intensive care syndrome therapy and care: engagement of non-critical care providers and survivors in a second stakeholders meeting. Crit Care Med. 2014;42(12):2518-26.[Crossref] [PubMed] 
  15. Smith S, Rahman O. Post intensive care syndrome. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020. p.1-31. (Baskı sayısı eklenmelidir.)[Link] 
  16. Davidson JE, Jones C, Bienvenu OJ. Family response to critical illness: postintensive care syndrome-family. Crit Care Med. 2012;40(2):618-24.[Crossref] [PubMed] 
  17. Schmidt M, Azoulay E. Having a loved one in the ICU: the forgotten family. Curr Opin Crit Care. 2012;18(5):540-7.[Crossref] [PubMed] 
  18. Kress JP, Hall JB. ICU-acquired weakness and recovery from critical illness. N Engl J Med. 2014;24;370(17):1626-35.[Crossref] [PubMed] 
  19. Latronico N, Bolton CF. Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. Lancet Neurol. 2011;10(10):931-41.[Crossref] [PubMed] 
  20. Farhan H, Moreno-Duarte I, Latronico N, Zafonte R, Eikermann M. Acquired muscle weakness in the surgical ıntensive care unit: nosology, epidemiology, diagnosis, and prevention. Anesthesiology. 2016;124(1):207-34.[Crossref] [PubMed] 
  21. Stevens RD, Marshall SA, Cornblath DR, Hoke A, Needham DM, de Jonghe B, et al. A framework for diagnosing and classifying intensive care unit-acquired weakness. Crit Care Med. 2009;37(10 Suppl):S299-308.[Crossref] [PubMed] 
  22. De Jonghe B, Bastuji-Garin S, Sharshar T, Outin H, Brochard L. Does ICU-acquired paresis lengthen weaning from mechanical ventilation? Intensive Care Med. 2004;30(6): 1117-21.[Crossref] [PubMed] 
  23. Dinglas VD, Aronson Friedman L, Colantuoni E, Mendez-Tellez PA, Shanholtz CB, Ciesla ND, et al. Muscle weakness and 5-year survival in acute respiratory distress syndrome survivors. Crit Care Med. 2017;45(3):446-53.[Crossref] [PubMed] [PMC] 
  24. Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM. Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med. 2007;33(11):1876-91.[Crossref] [PubMed] 
  25. Fan E, Dowdy DW, Colantuoni E, Mendez-Tellez PA, Sevransky JE, Shanholtz C, et al. Physical complications in acute lung injury survivors: a two-year longitudinal prospective study. Crit Care Med. 2014;42(4):849-59.[Crossref] [PubMed] [PMC] 
  26. Hermans G, Van Mechelen H, Clerckx B, Vanhullebusch T, Mesotten D, Wilmer A, et al. Acute outcomes and 1-year mortality of intensive care unit-acquired weakness. A cohort study and propensity-matched analysis. Am J Respir Crit Care Med. 2014;15;190(4):410-20.[Crossref] [PubMed] 
  27. Griffiths J, Hatch RA, Bishop J, Morgan K, Jenkinson C, Cuthbertson BH, et al. An exploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors: a 12-month follow-up study. Crit Care. 2013;28;17(3):R100.[Crossref] [PubMed] [PMC] 
  28. Davidson JE, Harvey MA, Bemis-Dougherty A, Smith JM, Hopkins RO. Implementation of the pain, agitation, and delirium clinical practice guidelines and promoting patient mobility to prevent post-intensive care syndrome. Crit Care Med. 2013;41(9 Suppl 1):S136-45.[Crossref] [PubMed] 
  29. Wolters AE, Slooter AJ, van der Kooi AW, van Dijk D. Cognitive impairment after intensive care unit admission: a systematic review. Intensive Care Med. 2013;39(3):376-86.[Crossref] [PubMed] 
  30. Hopkins RO, Suchyta MR, Snow GL, Jephson A, Weaver LK, Orme JF. Blood glucose dysregulation and cognitive outcome in ARDS survivors. Brain Inj. 2010;24(12):1478-84.[Crossref] [PubMed] 
  31. Davydow DS, Zatzick D, Hough CL, Katon WJ. In-hospital acute stress symptoms are associated with impairment in cognition 1 year after intensive care unit admission. Ann Am Thorac Soc. 2013;10(5):450-7.[Crossref] [PubMed] [PMC] 
  32. Jackson JC, Gordon SM, Ely EW, Burger C, Hopkins RO. Research issues in the evaluation of cognitive impairment in intensive care unit survivors. Intensive Care Med. 2004;30(11):2009-16.[Crossref] [PubMed] 
  33. Katz IR, Curyto KJ, TenHave T, Mossey J, Sands L, Kallan MJ. Validating the diagnosis of delirium and evaluating its association with deterioration over a one-year period. Am J Geriatr Psychiatry. 2001;9(2):148-59.[Crossref] [PubMed] 
  34. Needham DM, Dinglas VD, Morris PE, Jackson JC, Hough CL, Mendez-Tellez PA, et al, Hopkins RO; NIH NHLBI ARDS Network. Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up. Am J Respir Crit Care Med. 2013;188(5):567-76.[Crossref] [PubMed] [PMC] 
  35. Girard TD, Jackson JC, Pandharipande PP, Pun BT, Thompson JL, Shintani AK, et al. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med. 2010;38(7):1513-20.[Crossref] [PubMed] [PMC] 
  36. Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010;27;304(16):1787-94.[Crossref] [PubMed] [PMC] 
  37. Gordon SM, Jackson JC, Ely EW, Burger C, Hopkins RO. Clinical identification of cognitive impairment in ICU survivors: insights for intensivists. Intensive Care Med. 2004;30(11):1997-2008.[Crossref] [PubMed] [PMC] 
  38. Sukantarat KT, Burgess PW, Williamson RC, Brett SJ. Prolonged cognitive dysfunction in survivors of critical illness. Anaesthesia. 2005;60(9):847-53.[Crossref] [PubMed] 
  39. Jones C, Griffiths RD, Humphris G, Skirrow PM. Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care. Crit Care Med. 2001;29(3):573-80.[Crossref] [PubMed] 
  40. Davydow DS, Hough CL, Langa KM, Iwashyna TJ. Symptoms of depression in survivors of severe sepsis: a prospective cohort study of older Americans. Am J Geriatr Psychiatry. 2013;21(9):887-97.[Crossref] [PubMed] [PMC] 
  41. Davydow DS, Desai SV, Needham DM, Bienvenu OJ. Psychiatric morbidity in survivors of the acute respiratory distress syndrome: a systematic review. Psychosom Med. 2008;70(4):512-9.[Crossref] [PubMed] 
  42. Jackson JC, Obremskey W, Bauer R, Greevy R, Cotton BA, Anderson V, et al. Long-term cognitive, emotional, and functional outcomes in trauma intensive care unit survivors without intracranial hemorrhage. J Trauma. 2007;62(1):80-8.[Crossref] [PubMed] 
  43. Dowdy DW, Dinglas V, Mendez-Tellez PA, Bienvenu OJ, Sevransky J, Dennison CR, et al. Intensive care unit hypoglycemia predicts depression during early recovery from acute lung injury. Crit Care Med. 2008;36(10):2726-33.[Crossref] [PubMed] [PMC] 
  44. Kress JP. Sedation and mobility: changing the paradigm. Crit Care Clin. 2013;29(1):67-75.[Crossref] [PubMed] 
  45. Hopkins RO, Key CW, Suchyta MR, Weaver LK, Orme JF Jr. Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome. Gen Hosp Psychiatry. 2010;32(2):147-55.[Crossref] [PubMed] 
  46. Wunsch H, Christiansen CF, Johansen MB, Olsen M, Ali N, Angus DC, et al. Psychiatric diagnoses and psychoactive medication use among nonsurgical critically ill patients receiving mechanical ventilation. JAMA. 2014;311(11):1133-42.[Crossref] [PubMed] 
  47. Davydow DS, Gifford JM, Desai SV, Bienvenu OJ, Needham DM. Depression in general intensive care unit survivors: a systematic review. Intensive Care Med. 2009;35(5): 796-809.[Crossref] [PubMed] 
  48. Davydow DS, Gifford JM, Desai SV, Needham DM, Bienvenu OJ. Posttraumatic stress disorder in general intensive care unit survivors: a systematic review. Gen Hosp Psychiatry. 2008;30(5):421-34.[Crossref] [PubMed] [PMC] 
  49. Iwashyna TJ. Survivorship will be the defining challenge of critical care in the 21st century. Ann Intern Med. 2010;3;153(3):204-5.[Crossref] [PubMed] 
  50. Netzer G, Sullivan DR. Recognizing, naming, and measuring a family intensive care unit syndrome. Ann Am Thorac Soc. 2014;11(3): 435-41.[Crossref] [PubMed] [PMC] 
  51. Jezierska N. Psychological reactions in family members of patients hospitalised in intensive care units. Anaesthesiol Intensive Ther. 2014;46(1):42-5.[Crossref] [PubMed] 
  52. Sullivan DR, Liu X, Corwin DS, Verceles AC, McCurdy MT, Pate DA, et al. Learned helplessness among families and surrogate decision-makers of patients admitted to medical, surgical, and trauma ICUs. Chest. 2012; 142(6):1440-6.[Crossref] [PubMed] [PMC] 
  53. Wang S, Allen D, Perkins A, Monahan P, Khan S, Lasiter S, et al. Validation of a new clinical tool for post-intensive care syndrome. Am J Crit Care. 2019;28(1):10-8.[Crossref] [PubMed] [PMC] 
  54. Fan E, Cheek F, Chlan L, Gosselink R, Hart N, Herridge MS, et al; ATS Committee on ICU-acquired Weakness in Adults; American Thoracic Society. An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults. Am J Respir Crit Care Med. 2014;15;190(12):1437-46.[Crossref] [PubMed] 
  55. Schweickert WD, Hall J. ICU-acquired weakness. Chest. 2007;131(5):1541-9.[Crossref] [PubMed] 
  56. Woon FL, Dunn CB, Hopkins RO. Predicting cognitive sequelae in survivors of critical illness with cognitive screening tests. Am J Respir Crit Care Med. 2012;15;186(4):333-40.[Crossref] [PubMed] 
  57. Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695-9. Erratum in: J Am Geriatr Soc. 2019;67(9):1991.[Crossref] [PubMed] 
  58. Vlake JH, van Genderen ME, Schut A, Verkade M, Wils EJ, Gommers D, et al. Patients suffering from psychological impairments following critical illness are in need of information. J Intensive Care. 2020;8(6):1-10.[Crossref] [PubMed] [PMC] 
  59. Castro E, Turcinovic M, Platz J, Law I. Early mobilization: changing the mindset. Crit Care Nurse. 2015;35(4):e1-5; quiz e6.[Crossref] [PubMed] 
  60. Parker A, Sricharoenchai T, Needham DM. Early rehabilitation in the intensive care unit: preventing physical and mental health impairments. Curr Phys Med Rehabil Rep. 2013;1(4):307-14.[Crossref] [PubMed] [PMC] 
  61. Peris A, Bonizzoli M, Iozzelli D, Migliaccio ML, Zagli G, Bacchereti A, et al. Early intra-intensive care unit psychological intervention promotes recovery from post traumatic stress disorders, anxiety and depression symptoms in critically ill patients. Crit Care. 2011;15(1):R41. Erratum in: Crit Care. 2011;15(2):418.[Crossref] [PubMed] [PMC] 
  62. Czerwonka AI, Herridge MS, Chan L, Chu LM, Matte A, Cameron JI. Changing support needs of survivors of complex critical illness and their family caregivers across the care continuum: a qualitative pilot study of Towards RECOVER. J Crit Care. 2015;30(2):242-9.[Crossref] [PubMed] 
  63. Petrinec AB, Mazanec PM, Burant CJ, Hoffer A, Daly BJ. Coping strategies and posttraumatic stress symptoms in post-ICU family decision makers. Crit Care Med. 2015;43(6):1205-12.[Crossref] [PubMed] [PMC] 
  64. Ullman AJ, Aitken LM, Rattray J, Kenardy J, Le Brocque R, MacGillivray S, et al. Diaries for recovery from critical illness. Cochrane Database Syst Rev. 2014;9;2014(12):CD010468.[Crossref] [PubMed] [PMC] 
  65. Garrouste-Orgeas M, Coquet I, Périer A, Timsit JF, Pochard F, Lancrin F, et al. Impact of an intensive care unit diary on psychological distress in patients and relatives*. Crit Care Med. 2012;40(7):2033-40.[Crossref] [PubMed] 
  66. Jones C, Bäckman C, Griffiths RD. Intensive care diaries and relatives' symptoms of posttraumatic stress disorder after critical illness: a pilot study. Am J Crit Care. 2012;21(3):172-6.[Crossref] [PubMed] 
  67. Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, et al; American College of Critical Care Medicine. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41(1):263-306.[Crossref] [PubMed] 
  68. Ely EW. The ABCDEF bundle: science and philosophy of how ICU liberation serves patients and families. Crit Care Med. 2017;45(2):321-30.[Crossref] [PubMed] [PMC] 
  69. Balas MC, Vasilevskis EE, Olsen KM, Schmid KK, Shostrom V, Cohen MZ, et al. Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/ management, and early exercise/mobility bundle. Crit Care Med. 2014;42(5):1024-36.[Crossref] [PubMed] [PMC] 
  70. Salluh Jorge IF, Wang H, Schneider EB, Nagaraja N, Yenokyan G, Damluji A, et al. Outcome of delirium in critically ill patients: systematic review and meta-analysis. BMJ. 2015;350:h2538.[Crossref] [PubMed] [PMC] 
  71. Warlan H, Howland L. Posttraumatic stress syndrome associated with stays in the intensive care unit: importance of nurses' involvement. Crit Care Nurse. 2015;35(3):44-52; quiz 54.[Crossref] [PubMed] 
  72. Teixeira C, Rosa RG. [Post-intensive care outpatient clinic: is it feasible and effective? A literature review). Rev Bras Ter Intensiva. 2018;30(1):98-111.[Crossref] [PubMed] [PMC] 
  73. Van Der Schaaf M, Bakhshi-Raiez F, Van Der Steen M, Dongelmans DA, De Keizer NF. Recommendations for intensive care follow-up clinics; report from a survey and conference of Dutch intensive cares. Minerva Anestesiol. 2015;81(2):135-44.[PubMed] 
  74. Lautrette A, Darmon M, Megarbane B, Joly LM, Chevret S, Adrie C, et al. A communication strategy and brochure for relatives of patients dying in the ICU. N Engl J Med. 2007;1;356(5):469-78. Erratum in: N Engl J Med. 2007;12;357(2):203.[Crossref] [PubMed] 
  75. Curtis JR, Treece PD, Nielsen EL, Gold J, Ciechanowski PS, Shannon SE, et al. Randomized trial of communication facilitators to reduce family distress and intensity of end-of-life care. Am J Respir Crit Care Med. 2016;15;193(2):154-62.[Crossref] [PubMed] [PMC] 
  76. Sundararajan K, Sullivan TR, Chapman M. Determinants of family satisfaction in the intensive care unit. Anaesth Intensive Care. 2012;40(1):159-65. Erratum in: Anaesth Intensive Care. 2012;40(2):351.[Crossref] [PubMed] 

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4.1. "Turkiye Klinikleri" is completely free to determine which of the services and contents provided in the "SITE" will be charged.

4.2. People benefiting from the services provided by "Turkiye Klinikleri" and using the website can use the "SITE" only according to the law and only for personal reasons. Users have the criminal and civil liability for every process and action they take in the "SITE". Every USER agrees, declares and undertakes that they will not proceed by any function or action infringement of rights of "Turkiye Klinikleri"s and/or other third parties', they are the exclusive right holder on usage, processing, storage, made public and revealing any written, visual or auditory information reported to Turkiye Klinikleri" and/or "SITE" to the third parties. "USER" agrees and undertakes that s/he will not duplicate, copy, distribute, process, the pictures, text, visual and auditory images, video clips, files, databases, catalogs and lists within the "SITE", s/he will not be using these actions or with other ways to compete with "Turkiye Klinikleri", directly or indirectly.

4.3. The services provided and the context published within the "SITE" by third parties is not under the responsibility of "Turkiye Klinikleri", institutions collaborated with "Turkiye Klinikleri", "Turkiye Klinikleri" employee and directors, "Turkiye Klinikleri" authorized salespeople. Commitment to accuracy and legality of the published information, context, visual and auditory images provided by any third party are under the full responsibility of the third party. "Turkiye Klinikleri" does not promise and guarantee the safety, accuracy and legality of the services and context provided by a third party.

4.4. "USER"s cannot act against "Turkiye Klinikleri", other "USER"s and third parties by using the "SITE". "Turkiye Klinikleri" has no direct and/or indirect responsibility for any damage a third party suffered or will suffer regarding "USER"s actions on the "SITE" against the rules of the hereby "Terms of Use" and the law.

4.5. "USER"s accept and undertake that the information and context they provided to the "SITE" are accurate and legal. "Turkiye Klinikleri" is not liable and responsible for promising and guaranteeing the verification of the information and context transmitted to "Turkiye Klinikleri" by the "USER"s, or uploaded, changed and provided through the "SITE" by them and whether these information are safe, accurate and legal.

4.6. "USER"s agree and undertake that they will not perform any action leading to unfair competition, weakening the personal and commercial credit of "Turkiye Klinikleri" and a third party,  encroaching and attacking on personal rights within the "SITE" in accordance with the Turkish Commercial Code Law.

4.7. "Turkiye Klinikleri" reserves the right to change the services and the context within the "SITE"  anytime. "Turkiye Klinikleri" may use this right without any notification and timelessly. "USER"s have to make the changes and/or corrections "Turkiye Klinikleri" required immediately. Any changes and/or corrections that are required by "Turkiye Klinikleri", may be made by "Turkiye Klinikleri" when needed. Any harm, criminal and civil liability resulted or will result from changes and/or corrections required by "Turkiye Klinikleri" and were not made on time by the "USER"s belongs completely to the users.

4.8. "Turkiye Klinikleri" may give links through the "SITE" to other websites and/or "CONTEXT"s and/or folders that are outside of their control and owned and run by third parties. These links are provided for ease of reference only and do not hold qualification for support the respective web SITE or the admin or declaration or guarantee for the information inside. "Turkiye Klinikleri" does not hold any responsibility over the web-sites connected through the links on the "SITE", folders and context, the services or products on the websites provided through these links or their context.

4.9. "Turkiye Klinikleri" may use the information provided to them by the "USERS" through the "SITE" in line with the terms of the "PRIVACY POLICY" and "USER CONTRACT". It may process the information or classify and save them on a database. "Turkiye Klinikleri" may also use the USER's or visitor's identity, address, e-mail address, phone number, IP number, which sections of the "SITE" they visited, domain type, browser type, date and time information to provide statistical evaluation and customized services.

5. PROPRIETARY RIGHTS

5.1. The information accessed through this "SITE" or provided by the users legally and all the elements (including but not limited to design, text, image, html code and other codes) of the "SITE" (all of them will be called as studies tied to "Turkiye Klinikleri"s copyrights) belongs to "Turkiye Klinikleri". Users do not have the right to resell, process, share, distribute, display or give someone permission to access or to use the "Turkiye Klinikleri" services, "Turkiye Klinikleri" information and the products under copyright protection by "Turkiye Klinikleri". Within hereby "Terms of Use" unless explicitly permitted by "Turkiye Klinikleri" nobody can reproduce, process, distribute or produce or prepare any study from those under "Turkiye Klinikleri" copyright protection.

5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com