Turkiye Klinikleri Journal of Health Sciences

.: ORIGINAL RESEARCH
Inflammatory Potential of Medical Nutrition Therapy Plans in Some Neurologic Diseases: A Descriptive Cross-Sectional Research
Bazı Nörolojik Hastalıklarda Tıbbi Beslenme Tedavi Planlarının İnflamatuar Potansiyeli: Tanımlayıcı Kesitsel Araştırma
Elif EDE ÇİNTESUNa , Büşra Nur AŞIKb , Halime UĞURc , Jale ÇATAKd
aİstanbul Sabahattin Zaim University Faculty of Health Sciences, Department of Nutrition and Dietetics, Department of Nutritional Sciences, İstanbul, Türkiye
bİstanbul Sabahattin Zaim University, Institute of Graduate Education, Department of Nutrition and Dietetics, İstanbul, Türkiye
cİstanbul Medeniyet University Faculty of Health Sciences, Department of Nutrition and Dietetics, Department of Mass Nutrition Systems, İstanbul, Türkiye
dİstanbul Sabahattin Zaim University, Department of Nutrition and Dietetics, İstanbul, Türkiye
Turkiye Klinikleri J Health Sci. 2025;10(2):311-9
doi: 10.5336/healthsci.2024-106408
Article Language: EN
Full Text
ABSTRACT
 Objective: This study aims to evaluate the Dietary Inflammatory Index (DII) of medical nutrition therapy menus of neurological diseases. Material and Methods: Medical nutrition therapy menus compatible with Alzheimer's, Parkinson's, Multiple Sclerosis (MS), and Migraine, and the ketogenic diet model were taken from the source containing the diets for Medical Nutrition Therapy in Adult Diseases. The energy and nutrient values obtained from the diets were analyzed using the BeBiS program and then calculated in Microsoft Excel 365 using the formula developed for the DII calculation method. The amounts of the analyzed values that meet the requirement were evaluated by comparing them with TUBER 2022 data. Results: The DII scores of the medical nutrition therapy menus used for Parkinson's, Alzheimer's, MS, and migraine were -6.93, -6.27, -5.39, and -3.43, respectively, from largest to smallest; a negative DII score indicates antiinflammatory. In the ketogenic diet, a positive DII score was found and the diet was found proinflammatory (1.74). According to the DII scores of the diets, it was determined that menus used for Parkinson's, Alzheimer's, MS, and migraine had an antiinflammatory effect, while the ketogenic diet had an inflammatory effect. Conclusion: It has been observed that Parkinson's, Alzheimer's, MS, and migraine menus have antiinflammatory effects, while the ketogenic diet has inflammatory effects. In neurological diseases, inflammation plays a critical role in the progression of the disease and the exacerbation of symptoms. Dietary components that reduce or increase inflammation can affect the course of diseases. Therefore, determining the DII helps to understand the relationship between nutrition and inflammation.

Keywords: Dietary Inflammatory Index; neurological diseases; nutrition
ÖZET
 Amaç: Bu çalışmanın amacı, nörolojik hastalıkların tıbbi beslenme tedavisi menülerinde Diyet İnflamatuar İndeksini (Dİİ) değerlendirmektir. Gereç ve Yöntemler: Alzheimer, Parkinson, Multipl Skleroz ve Migren ile uyumlu tıbbi beslenme tedavisi menüleri ve ketojenik diyet modeli, Yetişkin Hastalıklarında Tıbbi Beslenme Tedavisi diyetlerini içeren kaynaktan alınmıştır. Diyetlerden elde edilen enerji ve besin öğesi değerleri BeBiS programı kullanılarak analiz edilmiş ve ardından Dİİ hesaplama yöntemi için geliştirilen formül kullanılarak Microsoft Excel 365'te hesaplanmıştır. Analiz edilen değerlerin gereksinimi karşılama miktarları TÜBER 2022 verileri ile karşılaştırılarak değerlendirilmiştir. Bulgular: Parkinson, Alzheimer, Multipl Skleroz ve migren için kullanılan tıbbi beslenme tedavisi menülerinin Dİİ skorları sırasıyla -6,93, -6,27, -5,39 ve -3,43 olup; negatif Dİİ skoru antiinflamatuar olduğunu göstermektedir. Ketojenik diyette ise pozitif bir Dİİ skoru bulunmuş ve diyetin proinflamatuar olduğu görüşmüştür (1,74). Diyetlerin Dİİ puanlarına göre Parkinson, Alzheimer, Multipl Skleroz ve migren için kullanılan menülerin antiinflamatuar etkiye sahip olduğu, ketojenik diyetin ise inflamatuar etkiye sahip olduğu belirlenmiştir. Sonuç: Parkinson, Alzheimer, Multipl Skleroz ve migren tedavisinde uygulanan menülerin antiinflamatuar, ketojenik diyetin ise inflamatuar etkileye sahip olduğu görülmüştür. Nörolojik hastalıklarda inflamasyon, hastalığın ilerlemesinde ve semptomların şiddetlenmesinde kritik bir rol oynar. İnflamasyonu azaltan veya artıran diyet bileşenleri hastalıkların seyrini etkileyebilir. Bu nedenle, Dİİ'yi belirlemek beslenme ve inflamasyon arasındaki ilişkiyi anlamaya yardımcı olmaktadır.

Anahtar Kelimeler: Diyet İnflamatuar İndeksi; nörolojik hastalıklar; beslenme
REFERENCES:
  1. Russell RD, Black LJ, Begley A. Nutrition education programs for adults with neurological diseases are lacking: a scoping review. Nutrients. 2022;14(8):1577. [Crossref]  [PubMed]  [PMC] 
  2. Feigin VL, Vos T, Nichols E, Owolabi MO, Carroll WM, Dichgans M, et al. The global burden of neurological disorders: translating evidence into policy. Lancet Neurol. 2020;19(3):255-65. [Crossref]  [PubMed]  [PMC] 
  3. Erkkinen MG, Kim MO, Geschwind MD. Clinical neurology and epidemiology of the major neurodegenerative diseases. Cold Spring Harb Perspect Biol. 2018;10(4):a033118. [Crossref]  [PubMed]  [PMC] 
  4. Hanamsagar R, Bilbo SD. Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development. J Steroid Biochem Mol Biol. 2016;160:127-33. [Crossref]  [PubMed]  [PMC] 
  5. Badaeva AV, Danilov AB, Clayton P, Moskalev AA, Karasev AV, et al. Perspectives on neuronutrition in prevention and treatment of neurological disorders. Nutrients. 2023;15(11):2505. [Crossref]  [PubMed]  [PMC] 
  6. Kurowska A, Ziemichód W, Herbet M, Piątkowska-Chmiel I. The role of diet as a modulator of the inflammatory process in the neurological diseases. Nutrients. 2023;15(6):1436. [Crossref]  [PubMed]  [PMC] 
  7. Lopez-Garcia E, Schulze MB, Fung TT, Meigs JB, Rifai N, Manson JE, et al. Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr. 2004;80(4):1029-35. [Crossref]  [PubMed] 
  8. Shivappa N, Steck SE, Hurley TG, Hussey JR, Hébert JR. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr. 2014;17(8):1689-96. [Crossref]  [PubMed]  [PMC] 
  9. Balomenos V, Bounou L, Charisis S, Stamelou M, Ntanasi E, Georgiadi K, et al. Dietary Inflammatory Index score and prodromal Parkinson's disease incidence: the HELIAD study. J Nutr Biochem. 2022;105:108994. [Crossref]  [PubMed] 
  10. Khorsha F, Mirzababaei A, Ghodoosi N, Togha M, Yekaninejad MS, Askarpour M, et al. Association between diet and migraine characteristics: The role of dietary inflammatory index. Curr J Neurol. 2020;19(2):67-75. [Crossref]  [PubMed]  [PMC] 
  11. Shi Y, Lin F, Li Y, Wang Y, Chen X, Meng F, et al. Association of pro-inflammatory diet with increased risk of all-cause dementia and Alzheimer's dementia: a prospective study of 166,377 UK Biobank participants. BMC Med. 2023;21(1):266. [Crossref]  [PubMed]  [PMC] 
  12. Zeng Z, Cen Y, Wang L, Luo X. Association between dietary inflammatory index and Parkinson's disease from National Health and Nutrition Examination Survey (2003-2018): a cross-sectional study. Front Neurosci. 2023;17:1203979. [Crossref]  [PubMed]  [PMC] 
  13. Degan D, Ornello R, Tiseo C, Carolei A, Sacco S, Pistoia F. The role of inflammation in neurological disorders. Curr Pharm Des. 2018;24(14):1485-501. [Crossref]  [PubMed] 
  14. Şanlıer N. Vakalarla Öğreniyorum: Yetişkin Hastalıklarında Tıbbi Beslenme Tedavisi -1. 1st ed. Ankara: Hedef Yayıncılık ve Mühendislik; 2019.
  15. Sağlık Bakanlığı. Türkiye Beslenme Rehberi. 2022. [Link] 
  16. Bianchi VE, Rizzi L, Somaa F. The role of nutrition on Parkinson's disease: a systematic review. Nutr Neurosci. 2023;26(7):605-28. [Crossref]  [PubMed] 
  17. Qu Y, Chen X, Xu MM, Sun Q. Relationship between high dietary fat intake and Parkinson's disease risk: a meta-analysis. Neural Regen Res. 2019;14(12):2156-63. [Crossref]  [PubMed]  [PMC] 
  18. Russell RD, Black LJ, Begley A. Navigating dietary advice for multiple sclerosis. Health Expect. 2021;24(3):853-62. [Crossref]  [PubMed]  [PMC] 
  19. Ruan Y, Chen L, She D, Chung Y, Ge L, Han L. Ketogenic diet for epilepsy: an overview of systematic review and meta-analysis. Eur J Clin Nutr. 2022;76(9):1234-44. [Crossref]  [PubMed] 
  20. Crosby L, Davis B, Joshi S, Jardine M, Paul J, Neola M, et al. Ketogenic diets and chronic disease: weighing the benefits against the risks. Front Nutr. 2021;8:702802. [Crossref]  [PubMed]  [PMC] 
  21. Gazerani P. Migraine and Diet. Nutrients. 2020;12(6):1658. [Crossref]  [PubMed]  [PMC] 
  22. Melo van Lent D, Mesa HG, Short MI, Gonzales MM, Aparicio HJ, Salinas J, et al. Association between dietary inflammatory index score and incident dementia: results from the Framingham heart study offspring cohort. medRxiv [Preprint]. 2023:2023.08.21.23294374. [Crossref]  [PubMed]  [PMC] 
  23. Rad EY, Saboori S, Tektonidis TG, Simpson-Yap S, Reece J, Hebert JR, et al. A systematic review and meta-analysis of Dietary Inflammatory Index and the likelihood of multiple sclerosis/ demyelinating autoimmune disease. Clin Nutr ESPEN. 2024;62:108-14. [Crossref]  [PubMed] 
  24. Sun Y, Li X, Zhang G, Han L, Wu H, Peng W, et al. Age and sex differences in the association between Dietary Inflammatory Index and severe headache or migraine: a nationwide cross-sectional study. Nutr Neurosci. 2024;27(5):477-86. [Crossref]  [PubMed] 

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