Journal of Traditional Medical Complementary Therapies

.: REVIEW
Kahve: Hastalıklara Karşı Koruyucu mu?
Coffee: Does it Protect Againts Diseases?
Nuriye KAHIRa, Ceren GEZERa
aDoğu Akdeniz Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Gazi Mağusa, KKTC
J Tradit Complem Med. 2021;4(2):263-74
doi: 10.5336/jtracom.2020-79089
Article Language: TR
Full Text
ÖZET
 Dünyada en çok tüketilen içeceklerden biri olan kahve, günlük hayatın vazgeçilmez bir parçası olarak ticari ve sosyal yaşam da önemli bir yere sahiptir. Kahve üretiminde Coffea Arabica ve Coffea Canephora (robusta) türleri yaygın olarak kullanılmaktadır. Kahve, kahve çekirdeklerinin olgunlaşması ve toplanması, sulu veya kurutma yöntemi ile kabuklarından ayrılması, kavrulması ve öğütülmesi şeklinde 4 farklı aşamadan geçmektedir. Kahveye uygulanan öğütme işlemi ile espresso, türk kahvesi, instant kahve gibi farklı kahve türleri elde edilmektedir. Kahve, kafein, klorojenik asit, kafeik asit, kahveol, kafestol, antioksidanlar ve farklı mineraller dâhil olmak üzere olumlu sağlık etkileri olan çeşitli biyoaktif bileşikleri içermektedir. Kahvenin sağlık üzerinde göstermiş olduğu farklı etkilerin kahvenin türü, pişirme yöntemi, tüketim şekli, miktarı ve kahvenin bileşimindeki biyoaktif bileşenlerin oranı ile ilgilidir. Erişkinlerde, günde 3 fincana kadar kahve tüketiminin obezite, hipertansiyon, hiperlipidemi, Tip 2 diyabet, kanser ve nörodejeneratif hastalıklar için riski azalttığı belirtilmiştir. Kahvenin olası sağlık etkilerinin daha iyi anlaşılması için daha fazla prospektif ve müdahale çalışmalarına ihtiyaç duyulmaktadır.

Anahtar Kelimeler: Kahve; fonksiyonel gıda; diyet; besin; kafein; sağlık
ABSTRACT
 Coffee is the most consumed bevarage in the world and it has an indispensable part of our social and commercial life. Coffea arabica and Coffea canephora (robusta) are widely used in the production of coffee. Coffee passes through four different stages: ripening and harvesting, separating from shells through watery or drying, roasting and grinding. Different coffee types such as espresso, turkish coffee and instant coffee are obtained by grinding the coffee. Coffee includes various bioactive compounds that have potential positive effects on health, including caffeine, chlorogenic acids, caffeic acid, kahweol, cafestol, antioxidants and different minerals. These different effects on health are related to the type of coffee, cooking method, the way and amount of consumption, and the proportion of bioactive components in the composition of coffee. It is stated that of three cups per day coffee consumption reduces the risk of obesity, hypertension, hyperlipidemia, Type 2 diabetes, cancer and neurodegenerative diseases in adults. Further prospective and intervention studies are needed for better understanding potential health effects of coffee.

Keywords: Coffee; functional food; diet; food; caffeine; health
REFERENCES:
  1. Şar S. [The place of the coffee in our healthy and social life]. Lokman Hekim J. 2012;2(2):35-44. [Link] 
  2. Vinícius de Melo Pereira G, Soccol VT, Brar SK, Neto E, Soccol CR. Microbial ecology and starter culture technology in coffee processing. Crit Rev Food Sci Nutr. 2017;57(13):2775-88. [PubMed] 
  3. Tzoulaki I. Moderate coffee intake and cardiovascular health; no grounds for concern. Nutr Metab Cardiovasc Dis. 2018;28(8):808-9. [PubMed] 
  4. Servillo L, Giovane A, Casale R, Cautela D, D'Onofrio N, Balestrieri ML, et al. Homostachydrine (pipecolic acid betaine) as authentication marker of roasted blends of Coffea arabica and Coffea canephora (Robusta) beans. Food Chem. 2016;205:52-7. [PubMed] 
  5. Knysak D. Volatile Compounds Profiles in Unroasted Coffea Arabica and Coffea Canephora Beans From Different Countries. Food Sci Technol. 2017;37(3):444-8. [Link] 
  6. Niseteo T, Komes D, Bel?čak-Cvitanović A, Horžić D, Budeč M. Bioactive composition and antioxidant potential of different commonly consumed coffee brews affected by their preparation technique and milk addition. Food Chem. 2012;134(4):1870-7. [PubMed] 
  7. Garg SK. Green coffee bean. In: Ramesh CG, Nutraceuticals, eds. Efficacy, Safety and Toxicity. 1st ed. Cambridge, Massachusetts, USA: Academic Press; 2016. p.653-67.
  8. Cornelis MC, Erlund I, Michelotti GA, Herder C, Westerhuis JA, Tuomilehto J. Metabolomic response to coffee consumption: application to a three-stage clinical trial. J Intern Med. 2018;283(6):544-57. [Link] 
  9. Hayakawa S, Oishi Y, Tanabe H, Isemura M, Suzuki Y. Tea, coffee and health benefits. In: Mérillon JM, Ramawat KG, eds. Bioactive Molecules in Food. Reference Series in Phytochemistry. 1st ed. Switzerland: Springer; 2019. p.1-58.
  10. Yılmaz B, Acar-Tek N, Sözlü S. Turkish cultural heritage: a cup of coffee. J Ethn Foods. 2017;4(4):213-20. [Crossref] 
  11. Katrin B, Rudolf E. Heat and mass transfer during the coffee drying process. J Food Engineering. 2010;99(4):430-36. [Link] 
  12. Fadai NT, Melrose J, Please CP, Schulman A, Van Gorder RA. A heat and mass transfer study of coffee bean roasting. Int J Heat Mass Transfer 2017;104:787-99. [Link] 
  13. Fabbri A, Cevoli C, Alessandrini L, Romani S. Numerical modeling of heat and mass transfer during coffee roasting process. J Food Engineering. 2011;105(2):264-9. [Link] 
  14. Çağlarırmak N, Ünal K. [A resarch about determination of mineral contents of coffee bean (C. arabica)]. J Food. 1999;24(1):53-7. [Link] 
  15. Jeszka-Skowron M, Zgoła-Grześkowiak A. Usage of capillary ısotachophoresis and antioxidant capacity measurement in analysis of changes in coffee properties after roasting, steaming and decaffeination. Food Anal Methods. 2017;10(5):1245-51. [Link] 
  16. de Melo Pereira GV, de Carvalho Neto DP, Magalhães Júnior AI, Vásquez ZS, Medeiros ABP, Vandenberghe LPS, et al. Exploring the impacts of postharvest processing on the aroma formation of coffee beans - A review. Food Chem. 2019;272:441-52. [PubMed] 
  17. Jeszka-Skowron M, Sentkowska A, Pyrzyńska K, De Pe-a MP. Chlorogenic acids, caffeine content and antioxidant properties of green coffee extracts: influence of green coffee bean preparation. Eur Food Res Technol. 2016;242(8):1403-9. [Link] 
  18. Alves RC, Soares C, Casal S, Fernandes JO, Oliveira MBP. Acrylamide in espresso coffee: influence of species, roast degree and brew length. Food Chem. 2010;119(3):929-34. [Link] 
  19. Özdestan Ö. Evaluation of bioactive amine and mineral levels in Turkish coffee. Food Res Int. 2014;61:167-75. [Link] 
  20. Sanz C, Czerny M, Cid C, Schieberle P. Comparison of potent odorants in a filtered coffee brew and in an instant coffee beverage by aroma extract dilution analysis (AEDA). Eur Food Res Technol. 2002;214(4):299-302. [Link] 
  21. Santos RM, Lima DR. Coffee consumption, obesity and type 2 diabetes: a mini-review. Eur J Nutr. 2016;55(4):1345-58. [PubMed] 
  22. Köseoğlu Yılmaz P, Hacıbekıroğlu I, Kolak U. Effect of roasting on antioxidant and anticholinesterase capacities of coffee. Journal of Food and Nutrition Research. 2014;53(3):232-9. [Link] 
  23. Budryn G, Żyżelewicz D, Nebesny E, Oracz J, Krysiak W. Influence of addition of green tea and green coffee extracts on the properties of fine yeast pastry fried products. Food Research International. 2013;50(1):149-160. [Link] 
  24. Esquivel P, Jiménez VM. Functional properties of coffee and coffee by-products. Food Res Int. 2012;46(2):488-95. [Link] 
  25. Baeza G, Sarriá B, Bravo L, Mateos R. Polyphenol content, in vitro bioaccessibility and antioxidant capacity of widely consumed beverages. J Sci Food Agric. 2018;98(4):1397-1406. [PubMed] 
  26. Saltan FZ, Kaya H. [Coffee: pharmacognosic review]. FABAD Journal of Pharmaceutical Sciences. 2018;43(3):279-89. [Link] 
  27. Pimentel GD, Micheletti TO, Nehlig A. Coffee İntake and obesity. In: Watson RR, ed. Nutrition in the Prevention and Treatment of Abdominal Obesity. 1st ed. USA: Elsevier; 2014. p.245-59.
  28. Grosso G, Stepaniak U, Micek A, Topor-Mądry R, Pikhart H, Szafraniec K, et al. Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study. Eur J Nutr. 2015;54(7):1129-37. [PubMed]  [PMC] 
  29. Nordestgaard AT, Thomsen M, Nordestgaard BG. Coffee intake and risk of obesity, metabolic syndrome and Type 2 diabetes: a Mendelian randomization study. Int J Epidemiol. 2015;44(2):551-65. [PubMed] 
  30. Song F, Oh J, Lee K, Cho MS. The effect of coffee consumption on food group intake, nutrient intake, and metabolic syndrome of Korean Adults-2010 KNHANES (V-1). NFS J. 2016;4:9-14. [Link] 
  31. Kim JH, Park YS. Light coffee consumption is protective against sarcopenia, but frequent coffee consumption is associated with obesity in Korean adults. Nutr Res. 2017;41:97-102. [PubMed] 
  32. Lee J, Kim HY, Kim J. Coffee Consumption and the Risk of Obesity in Korean Women. Nutrients. 2017;9(12):1340. [PubMed]  [PMC] 
  33. Kim HJ, Cho S, Jacobs DR Jr, Park K. Instant coffee consumption may be associated with higher risk of metabolic syndrome in Korean adults. Diabetes Res Clin Pract. 2014;106(1):145-53. [PubMed] 
  34. Bouchard DR, Ross R, Janssen I. Coffee, tea and their additives: association with BMI and waist circumference. Obes Facts. 2010;3(6):345-52. [PubMed]  [PMC] 
  35. Grosso G, Marventano S, Galvano F, Pajak A, Mistretta A. Factors associated with metabolic syndrome in a mediterranean population: role of caffeinated beverages. J Epidemiol. 2014;24(4):327-33. [PubMed]  [PMC] 
  36. O'Keefe JH, Bhatti SK, Patil HR, DiNicolantonio JJ, Lucan SC, Lavie CJ. Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality. J Am Coll Cardiol. 2013;62(12):1043-51. [PubMed] 
  37. Köksal E, Yardımcı H, Kocaadam B, Deniz Güneş B, Yılmaz B, Karabudak E. Relationship between dietary caffeine intake and blood pressure in adults. Int J Food Sci Nutr. 2017;68(2):227-33. [PubMed] 
  38. Oğuz S, Erdoğan Z. [Effect of coffee consumption on heart healt]. Turk J Card Nur. 2016;7(14):136-9. [Link] 
  39. Klag MJ, Wang NY, Meoni LA, Brancati FL, Cooper LA, Liang KY, et al. Coffee intake and risk of hypertension: the Johns Hopkins precursors study. Arch Intern Med. 2002;162(6):657-62. [PubMed] 
  40. Noordzij M, Uiterwaal CS, Arends LR, Kok FJ, Grobbee DE, Geleijnse JM, et al. Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J Hypertens. 2005;23(5):921-8. [PubMed] 
  41. Bennett JM, Rodrigues IM, Klein LC. Effects of caffeine and stress on biomarkers of cardiovascular disease in healthy men and women with a family history of hypertension. Stress Health. 2013;29(5):401-9. [PubMed] 
  42. Lopez-Garcia E, Orozco-Arbeláez E, Leon-Mu-oz LM, Guallar-Castillon P, Graciani A, Banegas JR, et al. Habitual coffee consumption and 24-h blood pressure control in older adults with hypertension. Clin Nutr. 2016;35(6):1457-63. [PubMed] 
  43. Navarro AM, Martinez-Gonzalez MA, Gea A, Ramallal R, Ruiz-Canela M, Toledo E. Coffee consumption and risk of hypertension in the SUN Project. Clin Nutr. 2019;38(1):389-97. [PubMed] 
  44. Grosso G, Micek A, Godos J, Pajak A, Sciacca S, Bes-Rastrollo M, et al. Long-Term Coffee Consumption Is Associated with Decreased Incidence of New-Onset Hypertension: A Dose-Response Meta-Analysis. Nutrients. 2017;9(8):890. [PubMed]  [PMC] 
  45. Sözlü S, Yılmaz B, Tek NA. [Coffee consumption and relation with some diseases]. SDÜ J Health Sci. 2017;8(2):33-9. [Link] 
  46. Lopez-Garcia E, van Dam RM, Willett WC, Rimm EB, Manson JE, Stampfer MJ, et al. Coffee consumption and coronary heart disease in men and women: a prospective cohort study. Circulation. 2006;113(17):2045-53. [PubMed] 
  47. Karabudak E, Türközü D, Köksal E. Association between coffee consumption and serum lipid profile. Exp Ther Med. 2015;9(5):1841-6. [PubMed]  [PMC] 
  48. Jee SH, He J, Appel LJ, Whelton PK, Suh I, Klag MJ. Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol. 2001;153(4):353-62. [PubMed] 
  49. Pourshahidi LK, Navarini L, Petracco M, Strain JJ. Coffee consumption and cardiometabolic health in UK adults: cross-sectional analysis of the national diet and nutrition survey. Proceedings Nutr Society. (2017);76(OCE3). [Link] 
  50. Zargar A, Auttapibarn C, Hong SH, Larson TJ, Hayworth KH, Ito MK. The effect of acute café latte ingestion on fasting serum lipid levels in healthy individuals. J Clin Lipidol. 2013;7(2):165-8. [PubMed] 
  51. Martínez-López S, Sarriá B, Mateos R, Bravo-Clemente L. Moderate consumption of a soluble green/roasted coffee rich in caffeoylquinic acids reduces cardiovascular risk markers: results from a randomized, cross-over, controlled trial in healthy and hypercholesterolemic subjects. Eur J Nutr. 2019;58(2):865-78. [PubMed] 
  52. Huxley R, Lee CM, Barzi F, Timmermeister L, Czernichow S, Perkovic V, et al. Coffee, decaffeinated coffee, and tea consumption in relation to incident Type 2 diabetes mellitus: a systematic review with meta-analysis. Arch Intern Med. 2009;169(22):2053-63. [PubMed] 
  53. Doo T, Morimoto Y, Steinbrecher A, Kolonel LN, Maskarinec G. Coffee intake and risk of Type 2 diabetes: the Multiethnic Cohort. Public Health Nutr. 2014;17(6):1328-36. [PubMed]  [PMC] 
  54. Carlström M, Larsson SC. Coffee consumption and reduced risk of developing type 2 diabetes: a systematic review with meta-analysis. Nutr Rev. 2018;76(6):395-417. [PubMed] 
  55. Alperet DJ, Rebello SA, Khoo EY, Tay Z, Seah SS, Tai BC, et al. The effect of coffee consumption on insulin sensitivity and other biological risk factors for Type 2 diabetes: a randomized placebo-controlled trial. Am J Clin Nutr. 2020;111(2):448-58. [PubMed] 
  56. Wedick NM, Brennan AM, Sun Q, Hu FB, Mantzoros CS, van Dam RM. Effects of caffeinated and decaffeinated coffee on biological risk factors for Type 2 diabetes: a randomized controlled trial. Nutr J. 2011;10:93. [PubMed]  [PMC] 
  57. Chrysant SG. The impact of coffee consumption on blood pressure, cardiovascular disease and diabetes mellitus. Expert Rev Cardiovasc Ther. 2017;15(3):151-6. [PubMed] 
  58. van Dam RM, Willett WC, Manson JE, Hu FB. Coffee, caffeine, and risk of Type 2 diabetes: a prospective cohort study in younger and middle-aged U.S. women. Diabetes Care. 2006;29(2):398-403. [PubMed] 
  59. Rasouli B, Ahlqvist E, Alfredsson L, Andersson T, Carlsson PO, Groop L, et al. Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults: a population-based case-control study. Diabetes Metab. 2018;44(4):354-60. [PubMed] 
  60. Bøhn SK, Blomhoff R, Paur I. Coffee and cancer risk, epidemiological evidence, and molecular mechanisms. Mol Nutr Food Res. 2014;58(5):915-30. [PubMed] 
  61. Simonsson M, Söderlind V, Henningson M, Hjertberg M, Rose C, Ingvar C, et al. Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status. Cancer Causes Control. 2013;24(5):929-40. [PubMed] 
  62. Yaghjyan L, Rich S, Mao L, Mai V, Egan KM. Interactions of coffee consumption and postmenopausal hormone use in relation to breast cancer risk in UK Biobank. Cancer Causes Control. 2018;29(6):519-25. [PubMed] 
  63. Godos J, Micek A, Marranzano M, Salomone F, Rio DD, Ray S. Coffee Consumption and Risk of Biliary Tract Cancers and Liver Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies. Nutrients. 2017;9(9):950. [PubMed]  [PMC] 
  64. Hu Y, Ding M, Yuan C, Wu K, Smith-Warner SA, Hu FB, et al. Association between coffee ıntake after diagnosis of colorectal cancer and reduced mortality. Gastroenterology. 2018;154(4):916-26.e9. [PubMed]  [PMC] 
  65. Ran HQ, Wang JZ, Sun CQ. Coffee consumption and pancreatic cancer risk: an update meta-analysis of cohort studies. Pak J Med Sci. 2016;32(1):253-9. [PubMed]  [PMC] 
  66. Sen A, Papadimitriou N, Lagiou P, Perez-Cornago A, Travis RC, Key TJ, et al. Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2019;144(2):240-50. [PubMed] 
  67. Sado J, Kitamura T, Kitamura Y, Sobue T, Nishino Y, Tanaka H, et al; Three-Prefecture Cohort Study Group. Association between coffee consumption and all-sites cancer incidence and mortality. Cancer Sci. 2017;108(10):2079-87. [PubMed]  [PMC] 
  68. Campdelacreu J. Parkinson disease and Alzheimer disease: environmental risk factors. Neurologia. 2014;29(9):541-9. English, Spanish. [PubMed] 
  69. Wierzejska R. Can coffee consumption lower the risk of Alzheimer's disease and Parkinson's disease? A literature review. Arch Med Sci. 2017;13(3):507-14. [PubMed]  [PMC] 
  70. Kim IY, O'Reilly ÉJ, Hughes KC, Gao X, Schwarzschild MA, Ascherio A. Differences in Parkinson's Disease Risk with Caffeine Intake and Postmenopausal Hormone Use. J Parkinsons Dis. 2017;7(4):677-84. [PubMed] 
  71. Qi H, Li S. Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease. Geriatr Gerontol Int. 2014;14(2):430-9. [PubMed] 
  72. Postuma RB, Anang J, Pelletier A, Joseph L, Moscovich M, Grimes D, et al. Caffeine as symptomatic treatment for Parkinson disease (Café-PD): A randomized trial. Neurology. 2017;89(17):1795-803. [PubMed]  [PMC] 
  73. Barranco Quintana JL, Allam MF, Serrano Del Castillo A, Fernández-Crehuet Navajas R. Alzheimer's disease and coffee: a quantitative review. Neurol Res. 2007;29(1):91-5. [PubMed] 
  74. Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M. Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers Dis. 2009;16(1):85-91. [PubMed] 
  75. Liu QP, Wu YF, Cheng HY, Xia T, Ding H, Wang H, et al. Habitual coffee consumption and risk of cognitive decline/dementia: A systematic review and meta-analysis of prospective cohort studies. Nutrition. 2016;32(6):628-36. [PubMed] 

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4.7. "Turkiye Klinikleri" reserves the right to change the services and the context within the "SITE"  anytime. "Turkiye Klinikleri" may use this right without any notification and timelessly. "USER"s have to make the changes and/or corrections "Turkiye Klinikleri" required immediately. Any changes and/or corrections that are required by "Turkiye Klinikleri", may be made by "Turkiye Klinikleri" when needed. Any harm, criminal and civil liability resulted or will result from changes and/or corrections required by "Turkiye Klinikleri" and were not made on time by the "USER"s belongs completely to the users.

4.8. "Turkiye Klinikleri" may give links through the "SITE" to other websites and/or "CONTEXT"s and/or folders that are outside of their control and owned and run by third parties. These links are provided for ease of reference only and do not hold qualification for support the respective web SITE or the admin or declaration or guarantee for the information inside. "Turkiye Klinikleri" does not hold any responsibility over the web-sites connected through the links on the "SITE", folders and context, the services or products on the websites provided through these links or their context.

4.9. "Turkiye Klinikleri" may use the information provided to them by the "USERS" through the "SITE" in line with the terms of the "PRIVACY POLICY" and "USER CONTRACT". It may process the information or classify and save them on a database. "Turkiye Klinikleri" may also use the USER's or visitor's identity, address, e-mail address, phone number, IP number, which sections of the "SITE" they visited, domain type, browser type, date and time information to provide statistical evaluation and customized services.

5. PROPRIETARY RIGHTS

5.1. The information accessed through this "SITE" or provided by the users legally and all the elements (including but not limited to design, text, image, html code and other codes) of the "SITE" (all of them will be called as studies tied to "Turkiye Klinikleri"s copyrights) belongs to "Turkiye Klinikleri". Users do not have the right to resell, process, share, distribute, display or give someone permission to access or to use the "Turkiye Klinikleri" services, "Turkiye Klinikleri" information and the products under copyright protection by "Turkiye Klinikleri". Within hereby "Terms of Use" unless explicitly permitted by "Turkiye Klinikleri" nobody can reproduce, process, distribute or produce or prepare any study from those under "Turkiye Klinikleri" copyright protection.

5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com