Journal of Traditional Medical Complementary Therapies

.: REVIEW
Kahve Tüketiminin Obezite Tedavisinde Destekleyici Rolü
The Role of Coffee Consumption in the Treatment of Obesity
Melahat Sedanur MACİTa, Eda KÖKSALb
aOndokuz Mayıs Üniversitesi Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Samsun, TÜRKİYE
bGazi Üniversitesi Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Ankara, TÜRKİYE
J Tradit Complem Med. 2020;3(1):119-27
doi: 10.5336/jtracom.2019-72433
Article Language: TR
Full Text
ÖZET
 Obezite, vücutta artmış yağ birikimiyle tanımlanan kronik bir hastalıktır. Obezite tedavisinde tıbbi beslenme tedavisi ve yaşam tarzı değişiklikleri tedavinin esas basamağını oluşturmaktadır. Ancak, son yıllarda obezite tedavisini destekleyecek etmenlerin belirlenmesinin obezite tedavisinde başarıyı artırabileceği öngörülmektedir. Kahve, yüksek orandaki fenolik bileşen ve kafein içeriğinden dolayı bu destekleyici faktörler arasında yer almaktadır. Kahve (Rubiaceae familyası, Coffea cinsi), genellikle tropikal iklimlerde yetişmekte olan bir bitki olup, bu bitkinin meyvelerinin çekirdeklerinden üretilen kahve içecek olarak tüketilmekte ve dünyada en çok tüketilen içecekler arasında yer almaktadır. Kahve, antioksidan bileşenlerden başta klorojenik asit esterlerinden kafeik asit ve kinik asit açısından zengin, kafein içeriği yüksek bir içecektir. Bu bileşiminin katkısıyla sağlık üzerine olumlu etkiler göstermektedir. Güncel veriler kahvenin adipozitenin baskılanması ve vücut ağırlığının azalması üzerine olumlu etkileri olduğunu bildirmektedir. Kahve ve kahve bileşenlerinin obezite üzerine olumlu etkilerini gösterdiği olası mekanizmalar, genlerin modülasyonu yoluyla yağ asidi β-oksidasyonunu, lipolitik ve termojenik etki, kahverengi yağ dokunun aktivasyonu, peroksizom proliferatör aktifleştirici reseptör-γ ekspresyonunun uyarılması şeklindedir. Hayvan çalışmaları, tamamına yakınında kahvenin obezite üzerine olumlu etkilerini rapor ederken, insan çalışmalarının çoğunda olumlu etki, bir kısmında ise olumsuz etkiler saptanmıştır. Ancak insan çalışmalarının gözlemsel nitelikte olması, doza bağımlı sorgulama yapılmaması, kahve türüne dair özel sorgulama yapılmaması öneri geliştirmeyi zorlaştırmaktadır. Bu çalışmada, mevcut çalışmaların derlenmesi ve güncel verilerin ortaya konulması amaçlanmaktadır.

Anahtar Kelimeler: Kafein; kahve; klorojenik asit; obezite; vücut ağırlığı
ABSTRACT
 Obesity is a chronic disease characterized by excessive or abnormal fat accumulation in the body. Medical nutrition therapy and lifestyle changes are the mainstay in obesity treatment. However, in recent years, determining the factors that support obesity treatment may increase the success of obesity treatment. Coffee is one of these supportive therapies due to its high content of phenolic compounds and caffeine. Coffee (Rubiaceae family, Coffea genus) is a plant that grows in tropical climates which is rich in chlorogenic acid esters, caffeic acid, cinnic acid, and caffeine. It has positive effects on health with the contribution of this composition. Recent data suggest that coffee has positive effects on suppression of adiposity and reduction in body weight. The possible mechanisms by that coffee and coffee constituents demonstrate positive effects on obesity include fatty acid β-oxidation by modulation of genes, lipolytic and thermogenic effect, activation of brown fat tissue, and stimulation of peroxisome proliferating activator receptor-γ expression. Almost all animal studies have reported the positive effects of coffee on obesity, whereas in most human studies positive effects have been identified and in some others negative effects. However, the fact that human studies are observational, no dose-dependent questioning, and no specific questioning about the type of coffee makes it difficult to develop suggestions. In this study, it is aimed to compile the current studies and present the current data.

Keywords: Caffeine; coffee; chlorogenic acid; obesity; body weight
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