Turkiye Klinikleri Journal of Cardiology

.: ORIGINAL RESEARCH
Kararlı ve Kararsız Anjina Pektorisli Olgularda Koroner Anjiyoplastinin QT Dispersiyonu Üzerine Etkisi
EFFECT OF CORONARY ANGIOPLASTY ON QT DISPERSION IN CASESWITH STABLE AND UNSTABLE ANGINA PECTORIS
Engin BOZKURT*, M. Kemal EROL*, Mahmut AÇIKEL*, Sebahattin ATEŞAL**
*, Atatürk Üniversitesi Tıp Fakültesi Kardiyoloji AD,
**, Atatürk Üniversitesi Tıp Fakültesi Kardiyoloji AD, ERZURUM
Turkiye Klinikleri J Cardiol. 2001;14(2):81-5
Article Language: TR
Full Text
ÖZET
Amaç: Standart oniki derivasyonlu elektrokardiyografide (EKG) en uzun QT süresinden en kısa QT süresinin çıkarılması ile hesaplanan QT dispersiyonu (QTd); ventriküllerin repolarizasyon farklılıklarından kaynaklanmaktadır. Akut miyokard infaktüsü gibi bazı kalp hastalıklarında QT dispersiyonunun arttığı ayrıca başarılı reperfüzyon ile QT dispersiyonunun azaldığı gösterilmiştir. Fakat başarılı koroner anjiyoplastinin (PTCA) kararlı ve kararsız anjinalı olgularda QTdnu nasıl etkilediği araştırılmamıştır. Bu çalışma; PTCAnın kararlı ve kararsız anjinalı olgularda QTd üzerine nasıl etki gösterdiğini araştırmak amacı ile yapıldı. Materyel ve Metod: Çalışmaya; koroner anjiyoplasti yapılmasına karar verilmiş 59 olgu (42 erkek, 17 kadın; ortalama yaş 56.13 ± 8.89) alındı. Olgular iki gruba ayrıldı. Grup I: Kararlı anjinası olanlar (19 erkek, 8 kadın; ortalama yaş 55.77 ± 9.12). Grup II: kararsız anjinası olanlar (23 erkek, 9 kadın; ortalama yaş 56.43 ± 8.82). Olgulara PTCA öncesi, PTCA sonrası 24. saatte ve 30. günde standart 12 derivasyonlu istirahat EKGsi çekilerek QTd ve düzeltilmiş QT dispersiyonu (QTcd) hesaplandı. Bulgular: PTCA öncesi QTcd grup IIdeki olgularda grup Ie göre anlamlı derecede yüksek bulundu (grup I: 68.77 ± 5.08, grup II: 74.75 ± 5.16, p<0.01). Başarılı PTCA sonrası 24. saatte; QT dispersiyonu tüm olgularda işlem öncesine göre anlamlı derecede azaldı (grup I: 49.25 ± 4.66, grup II: 52.62 ± 5.70; işlem öncesine göre her iki grupta da p<0.01). Fakat iki grup arasındaki QT dispersiyonu farkı azalmasına rağmen anlamlı olarak devam etti (p<0.05). PTCA sonrası 30. günde; QT dispersiyonu her iki grupta da azalmaya devam etti (QTcd Grup I: 38.51 ± 3.60, Grup II: 39.12 ± 3.92; işlem sonrası 24. saate göre p<0.01). Fakat 30. günde gruplar arasındaki QTd farkı kayboldu (p>0.05). Sonuç: QTdnun kararlı anjinalı olgulara göre kararsız anjinalı olgularda daha fazla arttığı ve başarılı PTCA ile her iki grupta da QT dispersiyonunun azaldığı fakat iki grup arasındaki QTd farkının ancak işlemden 1 ay sonra kaybolduğunu tespit ettik.

Anahtar Kelimeler: Koroner anjiyoplasti, QT dispersiyonu
ABSTRACT
Purpose: In a standard 12-lead electrocardiography (EKG), QT dispersion (QTd) calculated with maximal QT interval minus minimal QT interval has been demonstrated to reflect inhomogeneity of ventricular repolarisation. In some heart diseases, such as acute myocardial infarction, it is pointed out that the dispersion of QT increased; in addition, the dispersion of QT reduced with successful reperfusion. In the cases with chronic stable and unstable angina pectoris, it wasnt investigated that how successful coronary angioplasty (PTCA) affected QTd. This study was carried out with the aim of investigating how PTCA affected QTd in the cases with chronic stable and unstable angina pectoris. Materials and Methods: 59 cases, for whom coronary angioplasty decision was taken, were included to the study (42 males, 17 females; mean age: 56.13 ± 8.89 year ). Cases are separated two groups. Group I: who are chronic stable angina pectoris (19 males, 8 females; mean age: 55.77 ± 9.12 year). Group II: who are resting angina pectoris within last one week (23 males, 9 females; mean age: 56.43 ± 8.82 year). QTd and corrected QT dispersion (QTcd) was measured on standard 12 lead resting EKG before and 24 hours and 30 day after successful PTCA. Results: QTcd before PTCA was found significantly high in the cases in group II in terms of group I (group I: 68.77 ± 5.08, group II: 74.75 ± 5.16; p<0.01). After successful PTCA, QT dispersion on 24th hour reduced meaningfully in all cases in terms of before process (group I: 49.25 ± 4.66, group II: 52.62 ± 5.70; in both groups in terms of before process p<0.01). But it contuinued meaningfully (p<0.05) although QT dispersion difference between two groups reduced. QT dispersion on 30th day after PTCA contiuned to reduce in both groups (QTcd group I: 38.51 ± 3.60, group II: 39.12 ± 3.92; according to postprocess for 24th hour p<0.01). But on 30th day, QTd difference between the groups was disappeared (p>0.05). Conclusion: We determined that QTd increased in the cases with unstable angina pectoris than those of stable angina pectoris; and QT dispersion reduced in both groups with successful PTCA, but the difference of QTd between both groups lost only a month later the process.

Keywords: Coroner anjioplasti, QT dispersion

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