Turkiye Klinikleri Journal of Veterinary Sciences

.: REVIEW
Kedilerin İntersitisyel Sistitisi - Pandora Sendromu: Geleneksel Derleme
Feline Intersitiel Cystitis - Pandora Syndrome: Traditional Review
Erdem GÜLERSOYa, Mehmet MADENb
aHarran Üniversitesi Veteriner Fakültesi, İç Hastalıkları ABD, Şanlıurfa, Türkiye
bSelçuk Üniversitesi Veteriner Fakültesi, İç Hastalıkları ABD, Konya, Türkiye
Turkiye Klinikleri J Vet Sci. 2022;13(1):20-9
doi: 10.5336/vetsci.2021-83003
Article Language: TR
Full Text
ÖZET
 Kedilerin intersitisyel sistitisi [feline interstitiel cystitis (FIC)], veteriner hekimlik pratiğinde sık karşılaşılan, patogenezisi tam olarak aydınlatılamamış ve hasta sahiplerinde hayal kırıklığı oluşturan bir klinik olgu olarak güncelliğini korumaktadır. FIC olgularında; pollaküri, periüri, strangüri ve/veya hematüri gibi alt üriner sistem hastalığı belirtileri ile birlikte davranış bozuklukları, deri, kalp, endokrin/nöroendokrin veya gastrointestinal sistem hastalığı belirtileri gözlenmektedir. Bu çok faktörlü doğası nedeniyle 'Pandora Sendromu' olarak tanımlanmaktadır. Multifaktöriyel doğası nedeniyle Pandora Sendromu, her yaş, cinsiyet ve coğrafi dağılıma bağlı olarak her ırktan kedide görülebilir. FIC olgularının idrar kesesi ile sınırlı olmayan bir klinik problem olduğu, sinir, endokrin ve bağışıklık sistemlerinin çoklu, karmaşık ve değişken anormalliklerini kapsadığı ifade edilmektedir. Klinik belirtileriyle bir alt üriner sistem hastalığı olarak görülen FIC olgularında, idrar kesesi duvarı permeabilitesinin artışı, vazodilatasyon, ödem, vasküler sızıntı, eritrosit diapedezi ve hücresel infiltrasyonla karakterize bir nörojenik yangı tablosu geliştiği ve stres durumlarında idrar kesesinin sensörik uyarımını artıran adrenokortikal cevabın azalması ve sempatik sinir sistemi uyarımının artışı gibi nöroendokrin aks değişimleri olduğu bildirilmektedir. Tedavi yönetiminde çevresel düzenleme uygulamalarının başarılı olması, FIC olgusunun sadece bir alt üriner sistem hastalığı olarak görülmemesi gerektiğini ve çok yönlü tanısal değerlendirmelere ihtiyaç olduğunu göstermektedir. Sunulan derlemede, FIC olgularının patofizyolojisi, klinik belirtileri, stres ve tedavi yönetimini içeren güncel yaklaşımlara yer verilmiştir.

Anahtar Kelimeler: Kedi; stres; intersitisyel sistitis; feline intersitisyel sistitis; multimodel çevresel modifikasyon
ABSTRACT
 Feline interstitial cystitis (FIC) is a clinical phenomenon that is common in veterinary practice which its pathogenesis has not been fully elucidated and causes disappointment with owners. In FIC cases; behavioral disorders, skin, heart, endocrine/neuroendocrine or gastrointestinal system disease symptoms are observed together with lower urinary tract disease symptoms such as pollakiuria, periuria, stranguri and/or hematuria. It is defined as "Pandora Syndrome" due to its multifactorial nature. Due to its multifactorial nature, Pandora Syndrome can be seen in cats of all breeds, depending on age, sex and geographical distribution. It is stated that FIC cases are a clinical problem that is not limited to the bladder, and they include multiple, complex and variable abnormalities of the nervous, endocrine and immune systems. It has been reported in FIC that as a lower urinary system disease, a neurogenic inflammation characterized by increased urinary bladder wall permeability, vasodilation, edema, vascular leakage, erythrocyte diapedesis and cellular infiltration develops and during stress, decreased adrenocortical response and sympathetic nerve increase the sensory stimulation of the urinary bladder and changes in the neuroendocrine axis, such as increased stimulation. The success of environmental enrichment in treatment shows that FIC should not be defined as only a lower urinary system disease and that multidimensional diagnostic evaluations are needed. In this review, current approaches including the pathophysiology, clinical symptoms, stress and treatment management of FIC cases are presented.

Keywords: Cat; stress; interstitial cystitis; feline interstitial cystitis; mutimodal environmental modification
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Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

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-During various attacks to the website,

-Disruption of the website because of a virus.

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Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

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