Turkiye Klinikleri Journal of Veterinary Sciences

.: ORIGINAL RESEARCH
Leaky Gut and Giardia duodenalis Infection Associated Serum Zonulin Levels Among Calves: Randomized Clinical Study
Buzağılarda Sızıntılı Bağırsak ve Giardia duodenalis Enfeksiyonu ile İlişkili Serum Zonulin Seviyeleri: Randomize Klinik Çalışma
Deniz ALIÇ URALa
aAydın Adnan Menderes University, Faculty of Veterinary Medicine, Faculty Farm, Aydın, Türkiye
Turkiye Klinikleri J Vet Sci. 2022;13(2):46-50
doi: 10.5336/vetsci.2022-92569
Article Language: EN
Full Text
ABSTRACT
 Objective: Giardiasis is the most common encountered parasitic disease of a wide variety of animal species and intestinal malabsorption, and diarrhea are long term outcomes of giardiasis. Given elevated gut permeability-within the moneclature synonymleaky gut- has been suggested as a probable contander to inflammaging and gut dysbiosis, relatively very few data exist in ruminants. In the present study, therefore, field research prompted the present author to seek information on the relationship between a leaky gut and giardiasis (this subject was dept in analysis), through which are influencing growth performance (the special era of interest for her). Material and Methods: For this purpose, 11 calves in each group healthy control vs. giardia positive diarrheic were included in the study. Sera samples for zonulin levels were detected to those of giardia positive diarhheic calves. Results: Commercially available ELISA tests revealed that serum zonulin concentrations (mean) was higher in diarrheic giardia positive calves (n=11) in comparison to healthy ones (n=11) (63.35±3.73 ng/mL vs. 34.94±3.72 ng/mL). Conclusion: Results obtained from this study might have helped detection of leaky gut and intestinal permeability among diarrheic calves with giardiasis in which result should be taken into consideration could change treatment protocols by the veterinary surgeons.

Keywords: Dysbiosis; gut permeability; intestinal parasitic disease
ÖZET
 Amaç: Giyardiyazis, çok çeşitli hayvan türleri arasında en sık karşılaşılan paraziter hastalıktır ve bağırsaklarda emilim bozukluğu ve ishal, giyardiyazisin uzun vadeli sonuçlarıdır. Artmış bağırsak geçirgenliği göz önüne alındığında -moneklatür eş anlamlısı- sızıntılı bağırsak- yangı ve bağırsak disbiyozunun olası bir taşıyıcısı olarak öne sürülmüş olup, geviş getiren hayvanlarda nispeten çok az veri bulunmaktadır. Bu nedenle bu çalışmada, saha araştırması mevcut yazarı, sızıntılı bağırsak ile büyüme performansını (onun için özel bir ilgi dönemi) etkileyen giyardiyazis (bu konu analize tabi tutulmuştur) arasındaki ilişki hakkında bilgi aramaya sevk etmiştir. Gereç ve Yöntemler: Bu amaçla sağlıklı kontrol ve giyardiya pozitif ishalli her gruptan 11 buzağı çalışmaya dâhil edildi. Giyardiya pozitif ishalli buzağıların zonulin düzeyleri için serum örnekleri tespit edildi. Bulgular: Ticari olarak temin edilebilen ELISA testleri, ishalli giyardiya pozitif buzağılarda (n=11) sağlıklı olanlara (n=11) kıyasla serum zonulin konsantrasyonlarının (ortalama) daha yüksek olduğunu ortaya koydu (63,35±3,73 ng/mL'ye karşı 34,94±3,72 ng/mL). Sonuç: Bu çalışmadan elde edilen sonuçlar, giyardiyazis ile enfekte ishalli buzağılarda, sızıntılı bağırsak ve bağırsak geçirgenliğinin saptanmasına yardımcı olmuş olabilir ve bu sonucun dikkate alınması veteriner hekimler tarafından tedavi protokollerini değiştirebilir.

Anahtar Kelimeler: Disbiyozis; bağırsak geçirgenliği; bağırsak parazit hastalığı
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