Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Psödoeksfoliasyonlu Hastalarda Retina Sinir Lifi Kalınlığı ve Koroid Kalınlığının İncelemesi
Evaluation of Retinal Nerve Fiber Layer Thickness and Choroidal Thickness in Pseudoexfoliation Cases
Murat Sinan SARICAOĞLUa, Ahmet KARAKURTa, Mualla HAMURCUa, B. Şeyma DURMUŞ ECEa, Erdem KARABULUTb
aGöz Hastalıkları Kliniği, Ankara Numune Eğitim ve Araştırma Hastanesi,
bBiyoistatistik AD, Hacettepe Üniversitesi Tıp Fakültesi, Ankara, TÜRKİYE
Turkiye Klinikleri J Ophthalmol. 2019;28(2):86-90
doi: 10.5336/ophthal.2018-61345
Article Language: TR
Full Text
ÖZET
 Amaç: Psödoeksfoliasyon sendromu (PES) ve psödoeksfoliasyon glokomu (PEG) olan hastalarda retina sinir lifi kalınlığı (RSLK) ve koroid kalınlığı (KK) ölçümlerinin sağlıklı bireylerle karşılaştırılmasıdır. Gereç ve Yöntemler: Psödoeksfoliasyon sendromu olan 12 hastanın 23 gözü (grup 1), psödoeksfoliasyon glokomu olan 15 hastanın 29 gözü (grup 2) ve benzer yaş dağılımına sahip 26 sağlıklı bireyin 52 gözü (grup 3) çalışma kapsamına alındı. Tüm hastalara pupiller dilatasyon sonrası optik koherens tomografi cihazı (Cirrus SD OKT) ile RSLK ölçümleri (ortalama ve kadran) ve KK ölçümleri (subfoveal, nazal 500 μm, 1.500 μm, 2.000 μm ve temporal 500 μm, 1.500 μm, 2.000 μm) yapılarak sonuçlar kaydedildi. Veriler istatistiksel olarak karşılaştırıldı. İstatistiksel anlamlılık sınırı p<0,05 olarak kabul edildi. Bulgular: Grup 2 RSLK ortalama ve kadran ölçümleri (süperior, inferior, nazal, temporal) ve KK ölçüm değerleri (subfoveal, nasal 500 μm, 1.500 μm, 2.000 μm ve temporal 500 μm, 1.500 μm, 2.000 μm) kontrol grubu (grup 3) ile karşılaştırıldığında, tüm parametrelerde istatistiksel olarak anlamlı farklılık saptandı. Grup 1 verileri grup 3 ile mukayese edildiğinde ise, RSLK değerlerinde nazal ve temporal kadran hariç, diğer tüm parametrelerde anlamlı farklılık bulundu. Sonuç: Psödoeksfoliasyon glokomu olan hastalarda sağlıklı bireylere göre RSLK ve KK daha ince saptandı. Psödoeksfoliasyon sendromu olan hastalarda ise RSLK'nin nazal ve temporal kadranları hariç diğer tüm parametreler açısından anlamlı incelme belirlendi.

Anahtar Kelimeler: Psödoeksfoliasyon glokom; retina sinir lifi kalınlığı; koroid kalınlığı, optik koherens tomografi
ABSTRACT
 Objective: To compare retinal nerve fiber layer thickness (RNFLT) and choroidal thickness (CT) measurement in eyes with pseudoexfoliation syndrome, pseudoexfoliation glaucoma and healthy control subjects. Material and Methods: Twenty three eyes of 12 patients with pseudoexfoliative syndrome (group 1), 29 eyes of 15 patients with pseudoexfoliative glaucoma (group 2), and 52 healty eyes of 26 healthy subjects in the similar age (group 3) were in the study. RNLFT (average and quadrants) and CT (subfoveal, nasal 500 μm, 1.500 μm, 2.000 μm and temporal 500 μm, 1.500 μm, 2.000 μm) were measured by using Cirrus SD OCT. Data was compared statistically and p value of <0,05 was accepted as significant level. Results: When group 2 was compared with control group (group 3) in terms of average and quadrants RNFLT measurement and CT (subfoveal, nasal 500 μm, 1500 μm, 2000 μm and temporal 500 μm, 1.500 μm, 2.000 μm) measurement, a significant difference was determined statistically in all parameters (p<0.05). Group 1 was compared with group 3 and a significant difference was determined in all parameters excluding RNFLT values in nasal and temporal quadrants. Conclusion: Compared to healty individuals, RNFLT and CT measurement were more thin in the case of pseudoexfoliative glaucoma. However in the case of pseudoexfoliation syndrome, a significant thining was determined in all parameters excluding nasal and temporal quadrants RNFLT values.

Keywords: Pseudoexfoliation glaucoma; retinal neve fiber thickness; choroid thickness, optic coherence tomography
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