Turkiye Klinikleri Journal of Medical Sciences

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The Association Between Glutathione S-Transferase P1 105IIe>Val Gene Polymorphism and the Risk of Bladder Cancer: A Meta-Analysis
Glutatyon S-Transferaz P1 105IIe>Val Gen Polimorfizmi ve Mesane Kanseri Riski: Meta-analiz
Muhammad ILMAWANa, Avan Guntur SATRIAWANa, Yeni PURNAMASARIb, Bagus Aulia MAHDIc Fredo TAMARAd, Besut DARYANTOe, Atma GUNAWANf, Jonny Karunia FAJARd
aUniversitas Brawijaya Faculty of Medicine, Malang, INDONESIA
bUniversitas Brawijaya Faculty of Medicine, Department of Biomedicine, Malang, INDONESIA
cUniversitas Airlangga, Faculty of Medicine, Department of Internal Medicine, Surabaya, INDONESIA
dUniversitas Brawijaya, Faculty of Medicine, Department of Internal Medicine, Malang, INDONESIA
eUniversitas Brawijaya, Faculty of Medicine, Department of Urology, Malang, INDONESIA
fUniversitas Brawijaya, Faculty of Medicine, Department of Internal Medicine, Division of Nephrology and Hypertension, Malang, INDONESIA
Turkiye Klinikleri J Med Sci. 2020;40(2):250-9
doi: 10.5336/medsci.2019-71871
Article Language: EN
Full Text
ABSTRACT
 Objectives: In the last three decades, Glutathione STransferase P1 (GSTP1) 105IIe>Val had been extensively reported in the case of Bladder cancer (BC). However, conflicting results were observed among the studies. We aimed to perform a meta-analysis in effort to assess the association between GSTP1 105IIe>Val gene polymorphism and the risk of BC. Material and Methods: A meta-analysis was conducted between May and July 2019. Papers were searched in Pubmed, Embase, Cochrane, and Web of Science and information of interest was extracted. The correlation and effect estimation were analyzed using random or fixed effect model. Results: We collected 17 studies consisting of 4.236 cases and 5.085 controls. Our pooled calculation revealed that GSTP1 105IIe>Val gene polymorphism was not associated with the risk of BC (OR 95%CI=1.11 [0.97-1.26], p=0.1190). We also performed sub-group analyses in accordance with ethnicity and genotyping method. In ethnicity sub-group, we failed to clarify the correlation between GSTP1 105IIe>Val gene polymorphism and the risk of BC both in Asian and Caucasian sub-groups. While, in genotyping method sub-groups, either using polymerase chain reaction (PCR) or PCR-Restriction fragment length polymorphism (PCR-RFLP) had no significant association with the risk of BC. Conclusion: There is no association between GSTP1 105IIe>Val gene polymorphism and the risk of BC.

Keywords: Bladder cancer; GSTP1; SNP; meta-analysis
ÖZET
 Amaç: Son 30 yılda, Glutatyon S-Transferaz P1 (GSTP1) 105IIe>Val mesane kanseri (MK) vakalarında yoğun olarak bildirildi. Fakat çalışmalar arasında çelişkili sonuçlar vardı. GSTP1 105IIe>Val gen polimorfizmi ve MK riski arasındaki ilişkiyi değerlendirmek için bir metaanaliz yapmayı amaçladık. Gereç ve Yöntemler: Mayıs ve Temmuz 2019 arasında meta-analiz yapıldı. Pubmed, Embase, Cochrane ve Web of Science'daki makaleler araştırıldı ve ilgili bilgiler alındı. Korelasyon ve etki tahmini rastgele veya sabit etki modeli kullanılarak incelendi. Bulgular: Toplam 4.236 olgu ve 5.085 kontrolü kapsayan 17 çalışmayı topladık. Toplanmış hesaplama GSTP1 105IIe>Val gen polimorfizminin MK riski ile ilişkili olmadığını ortaya koydu (OR %95 GA=1.11[0,97-1,26], p=0,1190). Ayrıca etnisite ve genotiplendirme yöntemine uygun olarak alt grup analizleri yaptık. Etnisite alt grubunda, hem Asyalı hem de vrupalı ırkta GSTP1 105IIe>Val gen polimorfizmi ile BK arasındaki korelasyonu açıklayamadık. Genotiplendirme yöntemi alt gruplarında, polimeraz zincir reaksiyonu (PCR) veya PCR-kısıtlama fragman uzunluğu polimorfizmi (PCR-RFLP) kullanarak MK ile ilişki bulmadık. Sonuç: GSTP1 105IIe>Val gen polimorfizmi ile MK riski arasında ilişki yoktur.

Anahtar Kelimeler: Mesane kanseri; GSTP1; SNP; meta-analiz
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