Turkiye Klinikleri Journal of Medical Sciences

.: REVIEW
The Efficacy and Safety of Denosumab for Treating Giant Cell Tumor of Bone: A Systematic Review and Meta-Analysis
Kemiğin Dev Hücreli Tümörünün Tedavisinde Denosumabın Etkililiği ve Güvenliliği: Sistematik Bir Derleme ve Meta-Analiz
Chairul Arby DESIYANTOa, Rady DWIPAYANAb, Rieva ERMAWANc, Iwan SUTANTOd, Astri SOETANTOe, Jonny Karunia FAJARf
aGeneral Practitioner, Sofifi General Hospital, Sofifi, North Maluku, INDONESIA
bConsultant of Orthopaedic Spine, Department of Orthopaedic and Traumatology, Dr. Ramelan Navy Hospital, Surabaya, East Java, INDONESIA
cConsultant of Orthopaedic Spine, Department of Orthopaedic and Traumatology, Sebelas Maret University, Surakarta, Central Java, INDONESIA
dConsultant of Orthopaedic Hand and Microsurgery, Department of Orthopaedic and Traumatology, Dr. Ramelan Navy Hospital, Surabaya, East Java, INDONESIA
eGeneral Practitioner, Ba'a General Hospital, Rote Ndao, East Nusa Tenggara, INDONESIA
fBrawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Malang, East Java, INDONESIA
Turkiye Klinikleri J Med Sci. 2022;42(1):53-61
doi: 10.5336/medsci.2021-85869
Article Language: EN
Full Text
ABSTRACT
The adjuvant treatment of denosumab for the management of giant cell tumor of bone (GCTB) has been widely investigated. However, the inconclusive findings were observed. Therefore, our study aimed to assess the efficacy of denosumab for the adjuvant therapy in the management of GCTB. We conducted a meta-analysis study during the period of FebruaryAugust. Article search was conducted in PubMed, ScienceDirect, and Cochrane library. The predictor was denosumab administration, and the outcomes measures were local recurrence, blood loss, Musculoskeletal Tumor Society (MSTS) score, lung metastase, and malignant transformation. Data were analyzed using Z test to evaluate the association. We included 11 papers, consisting of 253 cases and 1,145 controls. The quality of the included article was evaluated using the Newcastle-Ottawa scale (NOS). Our results identified that denosumab administration was associated with lower blood loss and improved MSTS score compared to those without denosumab administration in patients with GCTB. However, GCTB patients with and without denosumab administration shared similar findings in the context of local recurrence, lung metastase, and malignant transformation. Our study has verified that denosumab administration as an adjuvant treatment for the management of GCTB is associated with lower blood loss during surgical procedure and improved MSTS score.

Keywords: Giant cell tumor of bone; denosumab; blood loss; local recurrence; Musculoskeletal Tumor Society score
ÖZET
Kemiğin dev hücreli tümörünün (KDHT) yönetiminde denosumab ile adjuvan tedavi geniş olarak araştırılmıştır. Fakat birbiriyle uyuşmayan sonuçlar gözlenmiştir. Bu nedenle çalışmamızda KDHT'nin yönetiminde adjuvan tedavi için denosumabın etkinliğinin değerlendirilmesi amaçlanmıştır. Şubat-Ağustos döneminde bir meta-analiz çalışması gerçekleştirdik. PubMed, ScienceDirect ve Cochrane kütüphanesinde makale araştırması yapıldı. Ön gördürücü denosumab uygulaması idi ve sonuç ölçümleri lokal nüks, kan kaybı, Kas-iskelet Tümörleri Derneği (Musculoskeletal Tumor Society -MSTS) skoru, akciğer metastazı ve malign transformasyon idi. Veriler ilişkiyi değerlendirmek için Z testi ile incelendi. Toplam 253 olgu ve 1.145 kontrol içeren 11 yazıyı aldık. Dahil edilen makalenin kalitesi Newcastle-Ottawa ölçeği (NOS) kullanılarak değerlendirildi. Bulgularımız denosumab uygulamasının KDHT olan ve denosumab uygulanmayan hastalar göre daha az kan kaybı ve daha iyi MSTS skoru ile ilişkili olduğunu göstermiştir. Fakat denosumab uygulanan ve uygulanmayan hastalar lokal nüks, akciğer metastazı ve malign transformasyon bakımından benzer sonuçlara sahipti. Çalışmamız KDHT yönetiminde adjuvan tedavi olarak denosumab uygulamasının cerrahi işlem sırasında daha az kan kaybı ile ve daha iyi MSTS skoru ile ilişkili olduğunu doğrulamıştır.

Anahtar Kelimeler: Kemiğin dev hücreli tümörü; denosumab; kan kaybı; lokal nüks; Kas-iskelet Tümörleri Derneği skoru
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We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com