Turkiye Klinikleri Journal of Neurology

.: ORIGINAL RESEARCH
The Predictive Role of CXCL12 (SDF-1 alpha) in Multiple Sclerosis
Multipl Sklerozda CXCL12'nin (SDF-1 alfa) Prediktif Rolü
Semra MUNGANa, Neşe ÖZTEKİNa, Işıl GÜZELa, Sema UYSALb
Clinics of
aNeurology,
bBiochemistry, Ankara Numune Training and Research Hospital, Ankara, TURKEY
Turkiye Klinikleri J Neur. 2018;13(3):62-6
doi: 10.5336/neuro.2018-61932
Article Language: EN
Full Text
ABSTRACT
Objective: Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating disease characterized by multifocal inflammation, progressive myelin loss and consequent axonal demyelination. Pathogenic mechanisms of MS are oligodendrocyte damage as a result of leukocyte chemotaxis to central nervous system and production of inflammatory mediators, demyelination and neuronal injury. CXCL12 (SDF-1 alpha) is a basic chemokine which is chemoattractant for resting and activated T cells. We aimed to evaluate whether CXCL12 levels may be a predictive marker of neuroinflammation in MS patients. Material and Methods: We designed a prospective case control study of fifty-four MS patients and twenty-eight healthy controls were enrolled to the study. Plasma CXCL12 levels of the groups were measured in blood samples. The groups were compared in terms of plasma CXCL12 levels. Lymphocyte count, which is a marker of inflammation, was also compared. In the study group subsequent analysis was demonstrated the association between clinical parameters and plasma CXCL12 levels. Results: CXCL12 levels were statistically higher than the control group. Mean CXCL12 level of MS patients was 2026,5±398,7 pg/ml and the mean CXCL12 level of the controls was 1840,6±256,0 pg/ml. Lymphocyte count of the patients was also statistically higher in the study group. According to the receiver operator characteristic (ROC) curve analysis mean CXCL12 levels were discriminative factors in patients in the study group. There was no statistically significant association between plasma CXCL12 levels and clinical parameters. Conclusion: We conclude that elevations in CXCL12 levels might be a promising marker pointing out the pathogenic role of inflammation in multiple sclerosis.

Keywords: Multiple sclerosis; CXCL12; lymphocyte count; inflammation
ÖZET
Amaç: Multipl Skleroz (MS) multifokal inflamasyon, ilerleyici miyelin yıkımı ve sonunda akson demiyelinizasyonu ile karakterize inflamatuar, otoimmun, demiyelinizan bir hastalıktır. MS'in patogenetik mekanizmaları, merkezi sinir sistemine (MSS) lökosit kemotaksisi ve inflamatuar mediatörlerin üretimi sonucu oluşan oligodentrosit hasarı, demiyelinizasyon ve nöronal yaralanmadır. CXCL12 (SDF-1 alfa), aktive edilmiş olan ve olmayan T hücreleri için kemoatraktan olan bir temel kemokindir. Çalışmamızda CXCL12 düzeylerinin MS hastalarında nöroinflamasyonun prediktif belirleyicisi olup olmayacağını değerlendirmeyi amaçladık. Gereç ve Yöntemler: Elli dört MS hastası ve 28 sağlıklı kontrol ile prospektif vaka kontrol çalışması yaptık. CXCL 12 düzeyleri, kan örneklerinde ölçülerek gruplar arasında karşılaştırıldı. Lenfosit sayısı inflamasyonun bir belirteci olarak gruplar arasında karşılaştırıldı. Çalışma grubunda klinik parametreler ile plazma CXCL12 seviyeleri arasındaki ilişki istatistiksel analizlerle gösterildi. Bulgular: MS hastalarının CXCL12 düzeyleri kontrol grubuna göre istatistiksel olarak daha yüksekti. MS hastalarının ortalama CXCL12 seviyesi 2026,5±398,7 pg/ml idi ve kontrollerin ortalama CXCL12 düzeyi 1840,6±256,0 pg/ml idi. Hastaların lenfosit sayıları da çalışma grubunda istatistiksel olarak daha yüksekti. ROC eğrisi analizine göre, CXCL12 seviyeleri çalışma grubundaki hastalarda ayırtedici faktörlerdi. Plazma CXCL12 düzeyleri ile klinik parametreler arasında istatistiksel olarak anlamlı bir ilişki yoktu. Sonuç: CXCL12 düzeylerindeki yükselmeler, multipl sklerozda inflamasyonun patojenik rolünü belirtmede umut vericidir.

Anahtar Kelimeler: Multipl skleroz; CXCL12; lenfosit sayısı; inflamasyon

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