Turkiye Klinikleri Journal of Medical Sciences

.: ORIGINAL RESEARCH
The Relationship Between Abdominal Adiposity Parameters and Renal Cell Carcinoma: A Volumetric Study Using All Computed Tomography Slices
Abdominal Yağ Parametreleri ve Renal Hücreli Karsinom Arasındaki İlişki: Tüm Bilgisayarlı Tomografi Kesitlerinin Kullanıldığı Hacimsel Çalışma
Sinan AKAYa, Turgay EBİLOĞLUb, Mehmet ERSENa, Uğurcan BALYEMEZa, Engin KAYAb, Mustafa TAŞARa
Clinics of
aRadiology,
bUrology, Health Sciences University Gülhane Training and Research Hospital, Ankara, TURKEY
Turkiye Klinikleri J Med Sci. 2019;39(1):65-74
doi: 10.5336/medsci.2018-62878
Article Language: EN
Full Text
ABSTRACT
 Objective: To investigate a possible relationship between abdominal adiposity parameters and the presence of renal cell carcinoma (RCC), and between these adiposity parameters and various histopathological tumor findings. Material and Methods: A total of 48 patients (31 males and 17 females, mean age: 60.17±13.39 years) with RCC and 50 control subjects (32 males and 18 females, mean age: 60.26±7.71 years) were enrolled. The medical data and the abdominopelvic computed tomography (CT) examinations of the study groups were retrospectively reviewed. The abdominal adiposity parameters, including visceral adipose tissue (VAT) volume, subcutaneous adipose tissue (SAT) volume, total adipose tissue (TAT) volume, visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), and VAT-to-SAT ratio, were calculated using specialized software. We also noted histopathological features of the tumors. Results: We found significantly higher SAT volume and SATI in the RCC group in comparison with the control group (p=0.024 and p = 0.001, respectively). The VAT volume and VATI were significantly lower in the patient group, compared to the control group (p = 0.001 for both). There was no statistically significant relationship between VAT-to-SAT ratio and the presence of RCC. No statistically significant relationship between abdominal adiposity parameters and histopathological tumor features was detected (p > 0.05). Conclusion: We designed a volumetric study of all slices of abdominopelvic CT examination by using specialized software. As far as we know, this study is the first volumetric study to investigate those relationships. Volumetric adipose tissue measurements may be more accurate than area measurements and can easily be performed during abdominopelvic CT examination, which is the routine imaging modality for RCC patients.

Keywords: Abdominal adipose tissue; renal cell carcinoma; pathology; subcutaneous adipose tissue; visceral adipose tissue; computed tomography
ÖZET
 Amaç: Abdominal yağ parametreleri ile renal hücreli karsinom (RHK) varlığı ve bu adipozite parametrelerinin tümörün histopatalojik bulguları ile arasındaki olası ilişkiyi araştırmak. Gereç ve Yöntemler: RHK'sı bulunan 48 hasta (31 erkek ve 17 kadın, ortalama yaş: 60,17±13,3 yıl) ve 50 kontrol hastası (32 erkek ve 18 kadın, ortalama yaş: 60,26±7,71 yıl) olmak üzere toplam 98 hasta çalışmaya dahil edildi. Çalışma gruplarının tıbbi kayıtları ve opaklı abdominopelvik bilgisayarlı tomografi (BT) tetkikleri retrospektif olarak değerlendirildi. BT tetkiklerinde, visseral yağ doku (VYD) hacmi, subkutan yağ doku (SYD) hacmi, total yağlı doku (TYD) hacmi, VYD indeks (VYDİ), SYD indeks (SYDİ) ve VYD/SYD oranlarını içeren abdominal yağ parametreleri özel bir yazılım kullanılarak hesaplandı. Ayrıca var olan tümörlerin histopatolojik özellikleri kaydedildi. Bulgular: RHK grubunda istatistiksel olarak anlamlı şekilde kontrol grubuna göre daha yüksek SYD hacmi ve SYDİ değerleri bulundu (sırasıyla p=0,024 ve p=0,001). Hasta grupta VYD hacmi ve VYDİ değerleri ise kontrol grubuna göre daha düşüktü (her ikisi için de p=0,001). VYD/SYD oranı ile RHK varlığı arasında anlamlı ilişki yoktu (p>0,05). Ayrıca değerlendirilen abdominal yağ parametreleri ve tümörlerin histopatolojik özellikleri arasında da anlamlı bir ilişki saptanmadı (p>0,05). Sonuç: Özel bir yazılım kullanarak tüm abdominopelvik BT kesitlerinin dahil edildiği hacimsel bir çalışma dizayn ettik. Bildiğimiz kadarıyla, bu çalışma tanımlanan ilişkileri araştıran ilk hacimsel çalışmadır. Hacimsel yağlı doku ölçümleri daha önceki çalışmalarda kullanılmış olan ve sadece birkaç kesit esas alınarak yapılan alansal ölçümlerden daha doğru olabilir ve RHK hastalarında rutin görüntüleme modalitesi olan abdominopelvik BT ile kolaylıkla yapılabilir.

Anahtar Kelimeler: Abdominal yağ doku; renal hücreli karsinom; patoloji; subkutan yağ doku; visseral yağ doku; bilgisayarlı tomografi
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