Journal of Literature Pharmacy Sciences

.: REVIEW
Wasabia Türlerinin Önemi ve Kullanımı
The Importance and Usages of Wasabia Species
Alev ÖNDERa, Ahsen Sevde ÇINARa, Zekiye Nihan ERTEMa
aFarmakognozi AD, Ankara Üniversitesi Eczacılık Fakültesi, Ankara, TÜRKİYE
J Lit Pharm Sci. 2019;8(1):51-60
doi: 10.5336/pharmsci.2018-62339
Article Language: TR
Full Text
ÖZET
Son yıllarda Japon mutfağının bilinirliği, dünyanın dört bir yanında hızla artmaktadır. Ülkemizde de yavaş yavaş toplum tarafından tanınmaya ve kabul görmeye başlayan Japon mutfağında yaygın olarak kullanılan Wasabia japonica (Miq.) Matsum [Syn. Eutrema japonicum (Miq.) Koidz.], bilinen ismi ile Wasabia, karakteristik tat ve aromaya sahip çok değerli bir bitkidir. Japon yemeklerinde taze olarak öğütülen ve çeşni olarak kullanılan ticari değeri yüksek bir üründür. Ayrıca, Batı mutfağında da çok beğenildiği ve kullanımı da bu nedenle arttığı için üretimi de buna bağlı olarak gittikçe yaygınlaşmaktadır. Yapılan araştırmalar sonucu, Wasabia'nın sağlığa olumlu katkılarının bulunması ve ayrıca lezzetinin farklı ve güzel olması günlük yaşamda kullanılabilecek fonksiyonel bir bitki olmasını sağlamaktadır. Wasabia cinsinin etken bileşikleri özellikle de izotiyosiyanatlar bakımından zengin oluşu ve bu bileşikler sayesinde biyolojik açıdan olumlu etkileri, bu cinsin önemini biraz daha artırmaktadır. Wasabia'nın öneminin diğer ülkelerde gün geçtikçe daha çok anlaşıldığı, ancak ülkemizde bu bitkinin çok fazla tanınmadığı gözlenmiştir. Bu çalışmada, Brassicaceae familyasına ait Wasabia cinsi ve bu cinse ait Wasabia türleri özellikle de dünyada kullanımı gittikçe yaygınlaşan Wasabia japonica türünün genel özelliklerinin, tarihçesinin, etken bileşiklerinin, farmakolojik etkilerinin, geleneksel kullanım alanlarının ve güncel kullanım şekillerinin incelenerek derlenmesi amaçlanmıştır.

Anahtar Kelimeler: Wasabia; turpgiller; baharat; Japon turpu
ABSTRACT
In recent years, the popularity of the Japanese cuisine has been increasing rapidly all over the world. Wasabia japonica (Miq.) Matsum [Syn. Eutrema japonicum (Miq.) Koidz.] known as Wasabia is widely used in the Japanese kitchen as a very valuable plant with characteristic taste and aroma, gradually becoming recognized in our country. It is a high commercial value, freshly grinded plant used as a condiment in Japanese foods. Because of its popularity in western cuisine, its production is becoming increasingly widespread. As Wasabia has a positive contribution to health and its taste is different and delicious, Wasabia is a functional plant that can be used daily life. The active compounds of the Wasabia, especially the isothiocyanates, which has important biological effects, increase the importance of this plant. It is understood that the Wasabia is becoming more and more popular in other countries, but not so much in our country. In this review, the Wasabia japonica belonging to the Brassicaceae family regarding to the general characteristics, history, active compounds, pharmacological effects, conventional usage areas and current usage patterns were compiled.

Keywords: Wasabia; Brassicaceae; spice; Japanese horseradish
REFERENCES:
  1. Chadwick CI, Lumpkin TA, Elberson LR. The botany, uses and production of Wasabia japonica (Miq) (Cruciferae) Matsum. Econ Bot. 1993;47(2):113-35. [Crossref]
  2. Morgan L. Hydroponic production of Wasabi & Japanese vegetables. In: Weller T, eds. Growing Edge-the Best of Growing Edge International 2000-2005. 1st ed. Corvallis, Or: New Moon Publishing; 2005. p.57.
  3. Ina K, Ina H, Ueda M, Yagi A, Kishima I. ωmethylthioalkyl isothiocyanates in wasabi. Agr Biol Chem. 1989;53(2):537-8. [Crossref]
  4. Hodge WH. Wasabi, native condiment plant of Japan. Econ Bot. 1974;28:118-29. [Crossref]
  5. Laurent C. The many lives of mustard: journey of a familiar condiment. The Journal of Canadian Food Cultures. 2013;4(2):2. [Crossref]
  6. Iwashina T. Eutrema japonicum. Curtis?s Bot Mag. 2016;33(3):217-25. [Crossref]
  7. Miles CA, Chadwick CI. Growing wasabi in the Pacific Northwest. A Pacific Northwest Extension Publication Washington State University Extension. 2008;2-9.
  8. Hoshitani Y. From wasabi cultivation to processing and selling. Agriculture Mountain Fishing Village Culture Association; 1996.
  9. Sultana T, Savage GP. Wasabi-Japanese horseradish. Bangladesh J Sci Ind Res. 2008;43(4):433-48. [Crossref]
  10. Gałczyńska A, Trzcınska P, Gumienna M, Nowak J, Hołubowİcz R. Production of Japanese horseradish (Wasabia japonica (Miq.) Matsumara) in Poland. Chemical contents of roots. Not Bot Horti Agrobo. 2017;45(2):466-72. [Crossref]
  11. Yoshida S, Hosoya T, Inui S, Masuda H, Kumazawa S. Component analysis of wasabi leaves and an evaluation of their anti-inflammatory activity. Food Sci Technol Res. 2015;21(2):247-53. [Crossref]
  12. Kumagai H, Kashima N, Seki T, Sakurai H, Ishii K, Ariga T. Analysis of components in the essential oil of upland wasabi and their inhibitory effects on platelet aggregation. Biosci Biotechnol Biochem. 1994;58:2131-35. [Crossref]
  13. Lehmann R, Schöbel N, Hatt H, van Thriel C. The involvement of TRP channels in sensory irritation: a mechanistic approach toward a better understanding of the biological effects of local irritants. Arch Toxicol. 2016;90(6): 1399-413. [Crossref] [PubMed]
  14. Masuda H, Harada Y, Tanaka K, Nakajima M, Tebeta H. Characteristic odorants of wasabi (Wasabia japonica Matsum), Japanese horseradish, in comparison with those of horseradish (armoracia rusticana). ACS Symposium Series. 1996;637(25):67-78. [Crossref]
  15. Etoh H, Nishimura A, Takasawa R, Yagi A, Saito K, Sakata K, et al. Omega methylsulfinylalkyl isothiocyanates in wasabi, Wasabia japonica Matsum. Agr Biol Chem. 1990;54(6):1587-9. [Crossref]
  16. Manyes L, Luciano FB, Mañes J, Meca G. In vitro antifungal activity of allyl isothiocyanate (AITC) against Aspergillus parasiticus and Penicillium expansum and evaluation of the AITC estimated daily intake. Food Chem Toxicol. 2015;83:293-9. [Crossref] [PubMed]
  17. Shin SW, Ghimeray AK, Park CH. Investigation of total phenolic, total flavonoid, antioxidant and allyl isothiocyanate content in the different organs of Wasabia japonica grown in an organic system. Afr J Tradit Complement Altern Med. 2014;11(3):38-45. [Crossref] [PubMed]
  18. Subedi L, Venkatesan R, Kim SY. Neuroprotective and anti-inflammatory activities of allyl isothiocyanate through attenuation of JNK/NF-B/TNF-signaling. Int J Mol Sci. 2017;18(7)E1423. [Crossref] [PubMed] [PMC]
  19. Uto T, Hou DX, Morinaga O, Shoyama Y. Molecular mechanisms underlying the anti-inflammatory actions of 6-(methylsulfinyl) hexyl isothiocyanate derived from wasabi (Wasabia japonica). Adv Pharmacol Sci. 2012;2012: 514046. [Crossref]
  20. Nabekura T, Kamiyama S, Kitagawa S. Effects of dietary chemopreventive phytochemicals on P-glycoprotein function. Biochem Biophys Res Commun. 2005; 327(3):866-70. [Crossref] [PubMed]
  21. Fuke Y, Shinoda S, Nagata I, Sawaki S, Murata M, Ryoyama K, et al. Preventive effect of oral administration of 6-(methylsulfinyl) hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum) against pulmonary metastasis of B16-BL6 mouse melanoma cells. Cancer Detect Prev. 2006;30(2):174-9. [Crossref] [PubMed]
  22. Nakanishi A, Miyazawa N, Haraguchi K, Watanabe H, Kurobayashi Y, Nammoku T. Determination of the absolute configuration of a novel odor-active lactone, cis-3-methyl-4decanolide, in wasabi (Wasabia japonica Matsum.). Flavour Fragr J. 2014;29:220-7. [Crossref]
  23. Fuke Y, Hishinuma M, Namikawa M, Oishi Y, Matsuzaki T. Wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human breast cancer by possible involvement of the NF-κB pathways. Nutr Cancer. 2014;66(5):879-87. [Crossref] [PubMed]
  24. Yano T, Yajima S, Virgona N, Yano Y, Otani S, Kumagi H, et al. The effect of 6-methylthiohexyl isothiocyanate isolated from Wasabia japonica (Wasabi) on 4-(methylnitrosamino)1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in mice. Cancer Lett. 2000;155(2): 115-20. [Crossref]
  25. Shimamura Y, Iio M, Urahira T, Masuda S. Inhibitory effects of Japanese horseradish (Wasabia japonica) on the formation and genotoxicity of a potent carcinogen, acrylamide. J Sci Food Agric. 2017;97(8):2419-25. [Crossref] [PubMed]
  26. Pedras MS, Sorensen JL, Okanga FI, Zaharia IL. Wasalexins A and B, new phytoalexins from wasabi: isolation and synthesis, and antifungal activity. Bioorg Med Chem Lett. 1999;9(20):3015-20. [Crossref]
  27. Lu Z, Dockery CR, Crosby M, Chavarria K, Patterson B, Giedd M. Antibacterial activities of wasabi against Escherichia coli O157:H7 and Staphylococcus aureus. Front Microbiol. 2016;7:1403. [Crossref] [PubMed] [PMC]
  28. Shin IS, Masuda H, Naohide K. Bactericidal activity of wasabi (Wasabia japonica) against Helicobacter pylori. Int J Food Microbiol. 2004;94(3):255-61. [Crossref]
  29. Depree JA, Howard TM, Savage GP. Flavour and pharmaceutical properties of the volatile sulfur compounds of wasabi (Wasabia japonica). Food Res Inter. 1999;31(5):329-37. [Crossref]
  30. Dorsch W, Adam O, Weber J, Ziegeltrum T. Antiasthmatic effects of onion extracts--detection of benzyland other isothiocyanates (mustard oils) as antiasthmatic compounds of plant origin. Euro J Pharmacol. 1985;107(1):17-24. [Crossref]
  31. Yamasaki M, Ogawa T, Wang L, Katsube T, Yamasaki Y, Sun X, et al. Anti-obesity effects of hot water extract from wasabi (Wasabia japonica Matsum.) leaves in mice fed high-fat diets. Nutr Res Pract. 2013;7(4):267-72. [Crossref] [PubMed] [PMC]
  32. Oowatari Y, Ogawa T, Katsube T, Iinuma K, Yoshitomi H, Gao M. Wasabi leaf extracts attenuate adipocyte hypertrophy through PPAR and AMPK. Biosci Biotechnol Biochem. 2016;80(8):1594-601. [Crossref] [PubMed]
  33. Lee YS, Yang JH, Bae MJ, Yoo WK, Ye S, Xue CC, et al. Antioxidant and antihypercholesterolemic activities of Wasabia japonica. Evid Based Complement Altern Med. 2010;7(4):459-64. [Crossref] [PubMed] [PMC]
  34. Kang JH, Choi S, Jang JE, Ramalingam P, Ko YT, Kim SY, et al. Wasabia japonica is a potential functional food to prevent colitis via inhibiting the NF-κB signaling pathway. Food Funct. 2017;8(8):2865-74. [Crossref] [PubMed]
  35. Morimitsu Y, Nakagawa Y, Hayashi K, Fujii H, Kumagai T, Nakamura Y, et al. A sulforaphane analog that potently activates the Nrf2-dependent detoxification pathway. J Biol Chem. 2002;277(5):3456-63. [Crossref] [PubMed]
  36. Fukuchi Y, Kato Y, Okunishi I, Matsutani Y, Osawa T, Naito M. 6-methylsulfinylhexyl isothiocyanate, an antioxidant derived from Wasabia japonica MATSUM, ameliorates diabetic nephropathy in Type 2 diabetic mice. Food Sci Technol Res. 2004;10(3):290-5. [Crossref]
  37. Yamado-Kato T, Nagai M, Ohnishi M, Yoshida K. Inhibitory effects of wasabi isothiocyanates on chemical mediator release in RBL-2H3 rat basophilic leukemia cells. J Nutr Sci Vitaminol (Tokyo). 2012;58(4):303-7. [Crossref]
  38. Chen YJ, Huang YC, Tsai TH, Liao HF. Effect of wasabi component 6-(methylsulfinyl) hexyl isothiocyanate and derivatives on human pancreatic cancer cells. Evid Based Complement Alternat Med. 2014;2014: 494739. [Crossref]
  39. Sultana T, Savage GP, McNeil DL, Porter N, Martin RJ. Flavour compounds in the rhizome of soil-grown wasabi. Proc Nutr Soc. 2000;25:95-106.
  40. Eugster A, Murmann P, Borer M, Kaenzig A. A real-time polymerase chain reaction (PCR) method for the detection of wasabi (Eutrema wasabi) in foods. Eur Food Res Technol. 2011;232(6):929-34. [Crossref]
  41. Gałczyńska A, Trzcınska P, Gumienna M, Nowak J, Hołubowıcz R. Production of japanese horseradish (Wasabia japonica (Miq.) Matsumara) in Poland chemical contents of roots. Not Bot Horti Agrobo. 2017;45(2):466-72. [Crossref]
  42. Soga O. Stimulative production of flaviolin by Phoma wasabia. Agric Biol Chem. 1982; 46(4):1061-3. [Crossref]
  43. Kojima M, Nakano Y. Studies on evaluation of the quality of Japanese horseradish (Wasabi) powder by gas chromatography. X. Studies of changes in pungent components during storage of horseradish, mustard and wasabi powder. J Jpn Soc Food Sci Technol. 1980;27(2):86-8. [Crossref]
  44. Kojima M, Hamada H, Yamashita M. Studies on the evaluation of quality of Japanese horseradish (Wasabi) powder by gas chromatography. XI. Studies on the stability of dried wasabi powder. J Jpn Soc Food Sci Technol. 1982;29(4):232-7. [Cross- ref]
  45. Gottschalk TE, Bailey JE. International Cosmetic Ingredient Dictionary and Handbook. Introduction INCI name monographs A-K. Vol 1. 10th ed. CTFA; 2004. p.1983.
  46. Nagai M, Akita K, Yamada K, Okunishi I. The effect of isosaponarin isolated from wasabi leaf on collagen synthesis in human fibroblasts and its underlying mechanism. J Nat Med.2010;64(3):305-12. [Crossref]

.: Up To Date

Login



Contact


Ortadoğu Reklam Tanıtım Yayıncılık Turizm Eğitim İnşaat Sanayi ve Ticaret A.Ş.

.: Address

Turkocagi Caddesi No:30 06520 Balgat / ANKARA
Phone: +90 312 286 56 56
Fax: +90 312 220 04 70
E-mail: info@turkiyeklinikleri.com

.: Manuscript Editing Department

Phone: +90 312 286 56 56/ 2
E-mail: yaziisleri@turkiyeklinikleri.com

.: English Language Redaction

Phone: +90 312 286 56 56/ 145
E-mail: tkyayindestek@turkiyeklinikleri.com

.: Marketing Sales-Project Department

Phone: +90 312 286 56 56/ 142
E-mail: reklam@turkiyeklinikleri.com

.: Subscription and Public Relations Department

Phone: +90 312 286 56 56/ 118
E-mail: abone@turkiyeklinikleri.com

.: Customer Services

Phone: +90 312 286 56 56/ 118
E-mail: satisdestek@turkiyeklinikleri.com

1. TERMS OF USE

1.1. To use the web pages with http://www.turkiyeklinikleri.com domain name or the websites reached through the sub domain names attached to the domain name (They will be collectively referred as "SITE"), please read the conditions below. If you do not accept these terms, please cease to use the "SITE." "SITE" owner reserves the right to change the information on the website, forms, contents, the "SITE," "SITE" terms of use anytime they want.

1.2. The owner of the "SITE" is Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. (From now on it is going to be referred as "Turkiye Klinikleri", shortly) and it resides at Turkocagi cad. No:30, 06520 Balgat Ankara. The services in the "SITE" are provided by "Turkiye Klinikleri."

1.3. Anyone accessing the "SITE" with or without a fee whether they are a natural person or a legal identity is considered to agree these terms of use. In this contract hereby, "Turkiye Klinikleri" may change the stated terms anytime. These changes will be published in the "SITE" periodically and they will be valid when they are published. Any natural person or legal identity benefiting from and reaching to the "SITE" are considered to be agreed to any change on hereby contract terms done by "Turkiye Klinikleri."

1.4. The "Terms of Use" hereby is published in the website with the last change on March 30th 2014 and the "SITE" is activated by enabling the access to everyone. The "Terms of Use" hereby is also a part of the any "USER Contract" was and/or will be done with the users using "Turkiye Klinikleri" services with or without a fee an inseparable.

2. DEFINITIONS

2.1. "SITE": A website offering different kind of services and context with a certain frame determined by "Turkiye Klinikleri" and it is accessible on-line on http://www.turkiyeklinikleri.com domain name and/or subdomains connected to the domain name.

2.2. USER: A natural person or a legal identity accessing to the "SITE" through online settings.

2.3. LINK: A link enabling to access to another website through the "SITE", the files, the context or through another website to the "SITE", the files and the context.

2.4. CONTEXT: Any visual, literary and auditory images published in the "Turkiye Klinikleri", "SITE" and/or any website or any accessible information, file, picture, number/figures, price, etc.

2.5. "USER CONTRACT": An electronically signed contract between a natural or a legal identity benefiting from special services "Turkiye Klinikleri" will provide and "Turkiye Klinikleri".

3. SCOPE OF THE SERVICES

3.1. "Turkiye Klinikleri" is completely free to determine the scope and quality of the services via the "SITE".

3.2. To benefit the services of "Turkiye Klinikleri" "SITE", the "USER" must deliver the features that will be specified by "Turkiye Klinikleri". "Turkiye Klinikleri" may change this necessity any time single-sided.

3.3. Not for a limited number, the services "Turkiye Klinikleri" will provide through the "SITE" for a certain price or for free are;

- Providing scientific articles, books and informative publications for health industry.

- Providing structural, statistical and editorial support to article preparation stage for scientific journals.

4. GENERAL PROVISIONS

4.1. "Turkiye Klinikleri" is completely free to determine which of the services and contents provided in the "SITE" will be charged.

4.2. People benefiting from the services provided by "Turkiye Klinikleri" and using the website can use the "SITE" only according to the law and only for personal reasons. Users have the criminal and civil liability for every process and action they take in the "SITE". Every USER agrees, declares and undertakes that they will not proceed by any function or action infringement of rights of "Turkiye Klinikleri"s and/or other third parties', they are the exclusive right holder on usage, processing, storage, made public and revealing any written, visual or auditory information reported to Turkiye Klinikleri" and/or "SITE" to the third parties. "USER" agrees and undertakes that s/he will not duplicate, copy, distribute, process, the pictures, text, visual and auditory images, video clips, files, databases, catalogs and lists within the "SITE", s/he will not be using these actions or with other ways to compete with "Turkiye Klinikleri", directly or indirectly.

4.3. The services provided and the context published within the "SITE" by third parties is not under the responsibility of "Turkiye Klinikleri", institutions collaborated with "Turkiye Klinikleri", "Turkiye Klinikleri" employee and directors, "Turkiye Klinikleri" authorized salespeople. Commitment to accuracy and legality of the published information, context, visual and auditory images provided by any third party are under the full responsibility of the third party. "Turkiye Klinikleri" does not promise and guarantee the safety, accuracy and legality of the services and context provided by a third party.

4.4. "USER"s cannot act against "Turkiye Klinikleri", other "USER"s and third parties by using the "SITE". "Turkiye Klinikleri" has no direct and/or indirect responsibility for any damage a third party suffered or will suffer regarding "USER"s actions on the "SITE" against the rules of the hereby "Terms of Use" and the law.

4.5. "USER"s accept and undertake that the information and context they provided to the "SITE" are accurate and legal. "Turkiye Klinikleri" is not liable and responsible for promising and guaranteeing the verification of the information and context transmitted to "Turkiye Klinikleri" by the "USER"s, or uploaded, changed and provided through the "SITE" by them and whether these information are safe, accurate and legal.

4.6. "USER"s agree and undertake that they will not perform any action leading to unfair competition, weakening the personal and commercial credit of "Turkiye Klinikleri" and a third party,  encroaching and attacking on personal rights within the "SITE" in accordance with the Turkish Commercial Code Law.

4.7. "Turkiye Klinikleri" reserves the right to change the services and the context within the "SITE"  anytime. "Turkiye Klinikleri" may use this right without any notification and timelessly. "USER"s have to make the changes and/or corrections "Turkiye Klinikleri" required immediately. Any changes and/or corrections that are required by "Turkiye Klinikleri", may be made by "Turkiye Klinikleri" when needed. Any harm, criminal and civil liability resulted or will result from changes and/or corrections required by "Turkiye Klinikleri" and were not made on time by the "USER"s belongs completely to the users.

4.8. "Turkiye Klinikleri" may give links through the "SITE" to other websites and/or "CONTEXT"s and/or folders that are outside of their control and owned and run by third parties. These links are provided for ease of reference only and do not hold qualification for support the respective web SITE or the admin or declaration or guarantee for the information inside. "Turkiye Klinikleri" does not hold any responsibility over the web-sites connected through the links on the "SITE", folders and context, the services or products on the websites provided through these links or their context.

4.9. "Turkiye Klinikleri" may use the information provided to them by the "USERS" through the "SITE" in line with the terms of the "PRIVACY POLICY" and "USER CONTRACT". It may process the information or classify and save them on a database. "Turkiye Klinikleri" may also use the USER's or visitor's identity, address, e-mail address, phone number, IP number, which sections of the "SITE" they visited, domain type, browser type, date and time information to provide statistical evaluation and customized services.

5. PROPRIETARY RIGHTS

5.1. The information accessed through this "SITE" or provided by the users legally and all the elements (including but not limited to design, text, image, html code and other codes) of the "SITE" (all of them will be called as studies tied to "Turkiye Klinikleri"s copyrights) belongs to "Turkiye Klinikleri". Users do not have the right to resell, process, share, distribute, display or give someone permission to access or to use the "Turkiye Klinikleri" services, "Turkiye Klinikleri" information and the products under copyright protection by "Turkiye Klinikleri". Within hereby "Terms of Use" unless explicitly permitted by "Turkiye Klinikleri" nobody can reproduce, process, distribute or produce or prepare any study from those under "Turkiye Klinikleri" copyright protection.

5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com