.: ORİJİNAL ARAŞTIRMA
Çocuk ve Adölesanlarda Metabolik Sendrom Bileşenleri ile D Vitamini Düzeyi Arasındaki İlişki: Kesitsel Araştırma
The Relationship Between Components of Metabolic Syndrome and Vitamin D Levels in Children and Adolescents: A Cross-Sectional Study
Turkiye Klinikleri J Health Sci. 2025;10(2):331-8
doi: 10.5336/healthsci.2024-106659
Makale Dili: TR
Tam Metin
ÖZET
Amaç: Çocuk ve adölesanlarda metabolik sendrom (MetS) bileşenleri ile D vitamini düzeyi arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntemler: Bu kesitsel çalışma, bir üniversite hastanesinin pediatri polikliniğine vücut ağırlığı artışı nedeniyle ile başvuran 6-18 yaş arası 118 çocukta yürütülmüştür. Çocuklara ait demografik bilgiler anket aracılığı ile toplanmıştır. Çocukların bazı antropometrik ölçümleri (vücut ağırlığı, boy uzunluğu, bel çevresi, boyun çevresi) alınmış olup vücut kompozisyon analizleri yapılmıştır. MetS tanısında çocuklar için modifiye edilmiş Ulusal Kolesterol Eğitim Programı Yetişkin Tedavi Paneli III [National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III)] kriterleri kullanılmıştır. Bulgular: NCEP ATP III kriterlerine göre MetS prevalansı %34,7'dir. Çocukların 73'ünde (%68,9) D vitamini eksikliği/yetersizliğinin olduğu saptanmıştır. Abdominal obezitesi olan çocuklarda D vitamini düzeyi abdominal obezitesi olmayanlara göre istatistiksel açıdan anlamlı derecede daha düşüktür (p=0,002). Çocukların abdominal obezite dışındaki MetS bileşenlerine göre D vitamini açısından istatistiksel açıdan anlamlı fark olmadığı saptanmıştır. MetS'li çocukların ortalama beden kitle indeksi (BKİ) z-skoru, boyun çevresi, bel çevresi ve vücut yağ yüzde değerleri MetS olmayanlara göre yüksektir (p<0,05). Serum 25(OH)D düzeyi ile BKİ z-skoru (r=-0,291, p=0,002), bel çevresi (r=-0,240, p=0,013), boyun çevresi (r=-0,331, p=0,001), vücut yağ yüzdesi (r=-0,348, p=0,001) ve sistolik kan basıncı (r=-0,204, p=0,036) arasında negatif yönde bir ilişki olduğu saptanmıştır (p<0,05). Sonuç: Bu çalışma sonucunda, yaklaşık her üç çocuktan birinde MetS saptanmış olup, MetS bileşenlerinde abdominal obezitesi olan çocuklarda D vitamini düzeylerinin daha düşük olduğu saptanmıştır. Bu sonuçlar, çocukluk çağında D vitamini düzeylerinin iyileştirilmesinin MetS riskini azaltma açısından yararlı olabileceğini düşündürmektedir.
Anahtar Kelimeler: Metabolik sendrom; D vitamini; abdominal obezite
Amaç: Çocuk ve adölesanlarda metabolik sendrom (MetS) bileşenleri ile D vitamini düzeyi arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntemler: Bu kesitsel çalışma, bir üniversite hastanesinin pediatri polikliniğine vücut ağırlığı artışı nedeniyle ile başvuran 6-18 yaş arası 118 çocukta yürütülmüştür. Çocuklara ait demografik bilgiler anket aracılığı ile toplanmıştır. Çocukların bazı antropometrik ölçümleri (vücut ağırlığı, boy uzunluğu, bel çevresi, boyun çevresi) alınmış olup vücut kompozisyon analizleri yapılmıştır. MetS tanısında çocuklar için modifiye edilmiş Ulusal Kolesterol Eğitim Programı Yetişkin Tedavi Paneli III [National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III)] kriterleri kullanılmıştır. Bulgular: NCEP ATP III kriterlerine göre MetS prevalansı %34,7'dir. Çocukların 73'ünde (%68,9) D vitamini eksikliği/yetersizliğinin olduğu saptanmıştır. Abdominal obezitesi olan çocuklarda D vitamini düzeyi abdominal obezitesi olmayanlara göre istatistiksel açıdan anlamlı derecede daha düşüktür (p=0,002). Çocukların abdominal obezite dışındaki MetS bileşenlerine göre D vitamini açısından istatistiksel açıdan anlamlı fark olmadığı saptanmıştır. MetS'li çocukların ortalama beden kitle indeksi (BKİ) z-skoru, boyun çevresi, bel çevresi ve vücut yağ yüzde değerleri MetS olmayanlara göre yüksektir (p<0,05). Serum 25(OH)D düzeyi ile BKİ z-skoru (r=-0,291, p=0,002), bel çevresi (r=-0,240, p=0,013), boyun çevresi (r=-0,331, p=0,001), vücut yağ yüzdesi (r=-0,348, p=0,001) ve sistolik kan basıncı (r=-0,204, p=0,036) arasında negatif yönde bir ilişki olduğu saptanmıştır (p<0,05). Sonuç: Bu çalışma sonucunda, yaklaşık her üç çocuktan birinde MetS saptanmış olup, MetS bileşenlerinde abdominal obezitesi olan çocuklarda D vitamini düzeylerinin daha düşük olduğu saptanmıştır. Bu sonuçlar, çocukluk çağında D vitamini düzeylerinin iyileştirilmesinin MetS riskini azaltma açısından yararlı olabileceğini düşündürmektedir.
Anahtar Kelimeler: Metabolik sendrom; D vitamini; abdominal obezite
ABSTRACT
Objective: To investigate the relationship between the components of metabolic syndrome (MetS) and vitamin D levels in children and adolescents. Material and Methods: This cross-sectional study was carried out in 118 children aged 6-18 years who were admitted to the paediatric outpatient clinic of a university hospital because of body weight gain and who were found to have hyperlipidaemia in biochemical tests and hypertension on examination. A questionnaire was used to collect demographic information about the children. Some anthropometric measurements (body weight, height, waist circumference, neck circumference) were taken, and body composition was determined. MetS was diagnosed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria adjusted for children. Results: According to NCEP ATP III criteria, the prevalence of MetS was 34.7%. 73 (68.9%) children have vitamin D deficiency/insufficiency. Vitamin D levels in children with abdominal obesity were significantly lower than those without abdominal obesity (p=0.002). Vitamin D levels were not statistically different by MetS component except for abdominal obesity. Children with MetS had higher body mass index (BMI) z score, neck circumference, waist circumference, and body fat percentage values compared to those without MetS (p<0.05). 25 (OH) D level was negatively correlated with BMI z score (r=-0,291, p=0.002), waist circumference (r=-0.240, p=0.013), neck circumference (r=-0.331, p=0.001), body fat percentage (r=-0.348, p=0.001) and systolic blood pressure (r=-0.204, p=0.036) (p<0.05). Conclusion: In this study, MetS was found in approximately one out of every three children and vitamin D levels were found to be lower in children with abdominal obesity as a component of MetS. These results suggest that improving vitamin D levels in childhood may be beneficial in terms of reducing the risk of MetS.
Keywords: Metabolic syndrome; vitamin D; abdominal obesity
Objective: To investigate the relationship between the components of metabolic syndrome (MetS) and vitamin D levels in children and adolescents. Material and Methods: This cross-sectional study was carried out in 118 children aged 6-18 years who were admitted to the paediatric outpatient clinic of a university hospital because of body weight gain and who were found to have hyperlipidaemia in biochemical tests and hypertension on examination. A questionnaire was used to collect demographic information about the children. Some anthropometric measurements (body weight, height, waist circumference, neck circumference) were taken, and body composition was determined. MetS was diagnosed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria adjusted for children. Results: According to NCEP ATP III criteria, the prevalence of MetS was 34.7%. 73 (68.9%) children have vitamin D deficiency/insufficiency. Vitamin D levels in children with abdominal obesity were significantly lower than those without abdominal obesity (p=0.002). Vitamin D levels were not statistically different by MetS component except for abdominal obesity. Children with MetS had higher body mass index (BMI) z score, neck circumference, waist circumference, and body fat percentage values compared to those without MetS (p<0.05). 25 (OH) D level was negatively correlated with BMI z score (r=-0,291, p=0.002), waist circumference (r=-0.240, p=0.013), neck circumference (r=-0.331, p=0.001), body fat percentage (r=-0.348, p=0.001) and systolic blood pressure (r=-0.204, p=0.036) (p<0.05). Conclusion: In this study, MetS was found in approximately one out of every three children and vitamin D levels were found to be lower in children with abdominal obesity as a component of MetS. These results suggest that improving vitamin D levels in childhood may be beneficial in terms of reducing the risk of MetS.
Keywords: Metabolic syndrome; vitamin D; abdominal obesity
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