Journal of Literature Pharmacy Sciences

Ağızda Hızlı Çözünen Tablet Formülasyonlarına Genel Bakış
Overview on the Orally Disintegrating Tablet Formulations
Emine Dilek ÖZYILMAZa,b, Tansel ÇOMOĞLUa
aFarmasötik Teknoloji AD, Ankara Üniversitesi Eczacılık Fakültesi, Ankara, TÜRKİYE
bFarmasötik Teknoloji AD, Doğu Akdeniz Üniversitesi Eczacılık Fakültesi, Gazimağusa, KKTC
J Lit Pharm Sci. 2019;8(2):97-107
doi: 10.5336/pharmsci.2018-63119
Article Language: TR
Full Text
ÖZET
Oral yolla ilaç kullanımı yaygın olarak kullanılan bir ilaç uygulama yoludur. Günümüzde, özellikle pediatrik, geriatrik ve herhangi bir nedenle yutma güçlüğü çeken hastalar için tedaviye uyumun sağlanması ve ilaç uygulamasının kolaylaştırılması amacıyla yeni dozaj formları üzerine çalışılmaktadır. Ağızda dağılan tabletler (ADT'ler) dil üzerine yerleştirildiğinde, tükürük yardımı ile parçalanan ve daha sonra suya ihtiyaç duymadan oromukozal boşluktan etken maddenin kan dolaşımına katıldığı tablet şekilleridir. Bu tablet formları, geleneksel katı dozaj şekillerinin sahip olduğu üstünlüklerin yanı sıra; hepatik metabolizmayı elimine ederek, daha fazla ilacın sistemik dolaşıma katılması ve bunun sonucunda da daha yüksek biyoyararlanım ve terapötik etkinliğe ulaşılması gibi diğer bazı avantajlara da sahiptirler. ADT'leri formüle etmek için, süblimasyon, liyofilizasyon vb. gibi klasik yöntemler kullanılmakla birlikte, patentli modifiye yöntemler de geliştirilmiştir. ADT'lerde, ağırlık sapması, ufalanma-aşınma, dağılma, çözünme ve etken madde miktar tayini gibi klasik tabletlerde yapılan kontrollerin yanı sıra tabletlerin ıslanma zamanı ve nem çekme miktarları da belirlenmektedir.

Anahtar Kelimeler: Ağızda dağılan tablet; ağızda dağılan tabletlerin üstünlükleri; ağızda dağılan tabletlerde kullanılan formülasyon yardımcıları; ağızda dağılan tabletlerin üretim yöntemleri; ağızda dağılan tabletlerde yapılan kontroller
ABSTRACT
Oral drug administration is a widely used administration route. Nowadays, new solid dosage forms are being studied to ensure compliance with medication and to facilitate drug administration especially for patients suffering from pediatric, geriatric, and swallowing difficulties for any reason. Oral disintegrating tablets (ODTs) are tablet forms which, when placed on the tongue, break up with the help of saliva and then join the bloodstream of the active substance from the oropharyngeal space without the need for water. Besides the advantages of conventional solid dosage forms, ODTs have some advantages, such as the ability of more drug to participate in systemic circulation, higher bioavailability and therapeutic efficacy. In addition to using conventional methods such as sublimation and lyophilization to formulate ODTs, patented modified methods have also been developed. After the ODTs are prepared, the wetting time and the amount of moisture of the tablets are tested, as well as the quality parameters performed on conventional tablets like weight deviation, friability, dissolution and assay.

Keywords: Orally disintegrating tablets; advantages of orally disintegrating tablets; excipient used in orally disintegrating tablets; preparation methods of orally disintegrating tablets; quality controls performed on orally disintegrating tablets
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