Journal of Traditional Medical Complementary Therapies

.: REVIEW
Apilarnilin Kimyasal Bileşimi ve Biyokimyasal Özellikleri: Geleneksel Derleme
Chemical Composition and Biochemical Properties of Apilarnil: Traditional Review
Cemre BAŞOLa , Meral KEKEÇOĞLUb
aDüzce Üniversitesi Sağlık Bilimleri Enstitüsü, Doğal Bitkisel ve Kozmetik Ürünler Doktora Programı, Düzce, Türkiye
bDüzce Üniversitesi Fen Edebiyat Fakültesi, Biyoloji Bölümü, Düzce, Türkiye
J Tradit Complem Med. 2023;6(2):159-68
doi: 10.5336/jtracom.2023-95372
Article Language: TR
Full Text
ÖZET
Arı ürünleri zengin kimyasal içeriği ve terapötik etkilerinden dolayı ilaç, kozmetik, gıda sanayisi ve apiterapi merkezlerinde kullanılmaktadır. Arı ürünlerine olan ilgi her geçen gün artmakta, bu artışla birlikte ürün yelpazesi ve bu ürünler ile tedavi yöntemleri de hızla gelişmektedir. Apilarnil (erkek arı larvası), son yıllarda araştırılmaya başlanan, halk hekimliğinde çeşitli sağlık sorunlarını tedavi etmek için kullanılan, popülaritesi giderek artan bir arı ürünüdür. Apilarnil Rusya, Çin, Slovakya, Ukrayna, Romanya gibi ülkelerde binlerce yıldır kullanılmasına rağmen ülkemizde ve pek çok Avrupa ülkesinde yaygın olarak bilinmeyen ancak ilaç olabilme potansiyeli taşıyan arı ürünlerinden biridir. Apilarnilin kimyasal içeriği ile ilgili yapılan çalışmalar, apilarnilin yüksek besin değerinin bir gıda bileşeni olarak ve tıbbi tedavi desteği için son derece önemli olduğunu göstermektedir. Bunun yanı sıra bir ilaca dönüşme potansiyeli taşıyan apilarnilin, ilaçta dozun önemi göz önüne alındığında, doz skalasının belirlenmesi için kimyasal kompozisyonuna hâkim olmak gereklidir. Bu nedenle bu çalışmada, apilarnilin kimyasal içeriği ile ilgili şimdiye kadar yapılan bilimsel çalışmalar derlenerek sonuçlar birbirleriyle kıyaslanmıştır. Tüm çalışmalar birlikte değerlendirildiğinde apilarnilin kimyasal bileşiminde karbohidratlar, şekerler, proteinler amino asitler, lipidler, doymuş ve doymamış yağ asitleri, hormonlar, vitaminler ve minerallerin yer aldığı belirlenmiştir. Ancak önceki çalışmalarda gerek içerik profili gerekse miktar ve birim bakımından farklılıklar olması apilarnilin kimyasal içeriği ile ilgili yorum yapmayı zorlaştırmaktadır. Bu derleme apilarnilin kimyasal içerik analizlerinde standart bir metot oluşturmak için yol gösterici olacaktır.

Anahtar Kelimeler: Erkek arı larvası; kimyasal bileşim; apiterapi; arı ürünleri; besinler
ABSTRACT
Bee products are used in medicine, cosmetics, food industry and apitherapy centers due to their rich chemical content and therapeutic effects. The interest in bee products is increasing day by day, and with this increase, the product range and treatment methods with these products are also developing rapidly. Apilarnil (drone brood larva) is an increasingly popular bee product that has been researched in recent years and is used in folk medicine to treat various health problems. Although apilarnil has been used for thousands of years in countries such as Russia, China, Slovakia, Ukraine and Romania, it is one of the bee products that is not widely known in our country and many European countries, but it has the potential to be a medicine. Studies on the chemical content of apilarnil show that the high nutritional value of apilarnil is extremely important as a food component and for medical treatment support. In addition; apilarnil, which has the potential to turn into a drug, is necessary to have knowledge of chemical composition of apilarnil in order to determine the dose scale, considering the importance of the dose of the drug. For this reason, in this study, scientific studies done so far on the chemical content of apilarnil were compiled and the results were compared with each other. When all studies were evaluated together; it was determined that the chemical composition of apilarnil includes carbohydrates, sugars, proteins, amino acids, lipids, saturated and unsaturated fatty acids, hormones, vitamins and minerals. However, in previous studies; differences in content profile, amount and unit make it difficult to comment on the chemical content of apilarnil. This review will be a guide to establish a standard method for chemical content analysis of apilarnil.

Keywords: Bee drone larvae; chemical composition; apitherapy; bee products; nutrient
REFERENCES:
  1. Bogdanov S. Bee venom: composition, health, medicine: a review. Peptides (NY). Published online. 2015;1:1-20. Available from: [Link] 
  2. Sforcin JM, Bankova V, Kuropatnicki AK. Medical benefits of honeybee products. Evidence-Based Complementary and Alternative Medicine. 2017. [Crossref]  [PubMed]  [PMC] 
  3. Kaur S, Mirza A, Singh J. Recent advances of honey in modern medicines: a review. Journal of Pharmacognosy and Phytochemistry. 2017;6(4):2063-7. [Link] 
  4. Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. Honey, propolis, and royal jelly: a comprehensive review of their biological actions and health benefits. Oxid Med Cell Longev. 2017;2017:1259510. [Crossref]  [PubMed]  [PMC] 
  5. McLennan SV, Bonner J, Milne S, Lo L, Charlton A, Kurup S, et al. The anti-inflammatory agent Propolis improves wound healing in a rodent model of experimental diabetes. Wound Repair Regen. 2008;16(5):706-13. [Crossref]  [PubMed] 
  6. Mandal MD, Mandal S. Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2011;1(2):154-60. [Crossref]  [PubMed]  [PMC] 
  7. Tasleem S. Honey is the best medicine in ancient and modern era. Journal of Hospital and Clinical Pharmacy. 2017;3(2):7-10. [Link] 
  8. Silici S, Koc AN, Mistik S. Comparison of in-vitro activities of antifungal drugs and propolis against yeasts isolated from patients with superficial mycoses. Annals of Microbiology. 2007;57(2):269-72. [Crossref] 
  9. Rahman MM, Richardson A, Sofian-Azirun M. Antibacterial activity of propolis and honey against Staphylococcus aureus and Escherichia coli. African Journal of Microbiology Research. 2010;4(16):1872-8. [Link] 
  10. Basualdo C, Sgroy V, Finola MS, Marioli JM. Comparison of the antibacterial activity of honey from different provenance against bacteria usually isolated from skin wounds. Vet Microbiol. 2007;124(3-4):375-81. [Crossref]  [PubMed] 
  11. Kuropatnicki AK, Szliszka E, Krol W. Historical aspects of propolis research in modern times. Evid Based Complement Alternat Med. 2013;2013:964149. [Crossref]  [PubMed]  [PMC] 
  12. Guine RPF. Bee pollen: chemical composition and potential beneficial effects on health. Current Nutrition & Food Science. 2015;11(4):301-8. [Crossref] 
  13. Yucel B, Acikgoz Z, Bayraktar H, Seremet C. Effect of apilarnil (drone bee larvae) administration on growth performance and secondary sex characteristics of male broilers. J Anim Vet Adv. 2011;10:1163-2266. [Crossref] 
  14. Sawczuk R, Karpinska J, Miltyk W. What do we need to know about drone brood homogenate and what is known. J Ethnopharmacol. 2019;245:111581. [Crossref]  [PubMed] 
  15. Wikiwand [Internet]. [Cited: January 09, 2023]. Bee brood. Available from: [Link] 
  16. Rutka V, Galoburda R, Galins J, Galins A. Bee drone brood homogenate chemical composition, stabilization and application: a review. Food Sci. 2021;36:96-103. [Crossref] 
  17. De Oliveira TS, Engels W. Classification of substages in preimaginal development of honey bee drones (Hymenoptera: Apidae). Entomol. Gen. 2013;34:287-93. [Crossref] 
  18. Yücel B, Sahin H, Yıldız O, Kolaylı S. Bioactive components and effect mechanism of apilarnil. J. Anim. Prod. 2019;60(2):125-30. [Crossref] 
  19. Kekeçoğlu M, Çaprazlı T, Ağan K. Erkek Arı Larvasının Sağlık Üzerine Etkisi. Kadirli Uygulamalı Bilimler Fakültesi Dergisi. 2021;1(2):139-53. Erişim linki: [Link] 
  20. Honey Bee Research Centre [Internet]. [Cited: January 08, 2023]. Stages of Bee Growth. Available from: [Link] 
  21. Meda A, Lamien CE, Millogo J, Romito M, Nacoulma OG. Therapeutic uses of honey and honeybee larvae in central Burkina Faso. J Ethnopharmacol. 2004;95(1):103-7. [Crossref]  [PubMed] 
  22. Jensen AB, Evans J, Jonas-Levi A, Benjamin O, Martinez I, Dahle B, et al. Standard methods for Apis mellifera brood as human food. Journal of Apicultural Research. 2016;56. [Crossref] 
  23. Acikgoz Z, Yucel B. Using facilities of apilarnil (bee drone larvae) in poultry nutrition. Works of the Faculty of Agriculture and food Sciences. University of Sarajevo. 2016;61:12-5. [Link] 
  24. Muraviev DW, Kalachinskaya AM. Drone homogenate and hens productivity. Viestnik Kazanskovo GAU. 2014;9(1):130-4. [Crossref] 
  25. Vakina TN, Petrova EV, Trifonov VN, Fedorov EN, Fedorov AV, Andreeva ES, et al. Method for restoring male sex drive (libido). United States Patent Application Publication. 2017;US 9730973 B2. [Link] 
  26. Vasilenko YK, Klimova OV, Lazaryan DS. Biological effect of drone brood under chronic hyperlipidemia conditions. Pharm Chem J. 2002;36:434-6. [Crossref] 
  27. Vasilenko YK, KlishinaI I. Lazaryan DS. A comparative study of the immunotropic and hepatotropic action of beekeeping products in rats with drug-induced hepatitis. Pharm Chem J. 2005;39:319-22. [Crossref] 
  28. Doğanyiğit Z, Okan A, Kaymak E, Pandır D, Silici S. Investigation of protective effects of apilarnil against lipopolysaccharide induced liver injury in rats via TLR 4/ HMGB-1/ NF-κB pathway. Biomed Pharmacother. 2020;125:109967. [Crossref]  [PubMed] 
  29. Andritoiu CV, Lungu C, Danu M, Ivanescu B, Andriescu CE, Vlase L, et al. Evaluation of the healing effect of ointments based on bee products on cutaneous lesions in wistar rats. Pharmaceuticals (Basel). 2021;14(11):1146. [Crossref]  [PubMed]  [PMC] 
  30. Andritou CV, Andritou V, Zonda GI, Foia L, Carlan M, Costuleanu M. Experimental treatment involving apitherapy in hereditary hemolyticanemia. Romanian Journal of Medical and Dental Education. 2012;1:34-7. [Link] 
  31. Kogalniceanu S, Lancrajan I, Ardelean G. Changes of the glucidic metabo-lism determined by the physical effort of the treatment with aslavital and apilarnil. Arad Medical Journal. 2010;13:33-41. [Link] 
  32. Yokoyama Y, Shinohara K, Kitamura N, Nakamura A, Onoue A, Tanaka K, et al. Metabolic effects of bee larva-derived protein in mice: assessment of an alternative protein source. Foods. 2021;10(11):2642. [Crossref]  [PubMed]  [PMC] 
  33. Stângaciu, S, Apiterapy course notes. Constanţa Apiterapy Research Hospital. Bucuresti. Romania. 1999;1. Erişim linki: [Link] 
  34. Prikhodko A, Yankina O, Kim N, Koltun G, Skolo A. Chemical composition of the far eastern homogenate of drone brood. E3S Web of Conferences. 2020;203:04-015. [Crossref] 
  35. Finke MD. Nutrient composition of bee brood and its potential as human food. Ecology of Food and Nutrition. 2005;44(4):257-70. [Crossref] 
  36. Narumi S. Honeybee brood as a nutritional food. Mitsubachi Kagaku (Honeybee Science). 2004;25:119-24. Available from: [Link] 
  37. Bogdanov S. Royal jelly, bee brood: composition, health, medicine: a review. Bee Product Science. 2016:1-36. [Link] 
  38. Ilieşiu NV. Apilarnil. Editura Apimondia, Bucuresti. Romania. 1991. Available from: [Link] 
  39. Sidor E, Dżugan M. Drone brood homogenate as natural remedy for treating health care problem: a scientific and practical approach. Molecules. 2020;25(23):5699. [Crossref]  [PubMed]  [PMC] 
  40. Krell R. Value-Added Products from Beekeeping. 1st ed. Roma: FAO Food and Agriculture Organization of the United Nations; 1996. [Link] 
  41. Bărnuțiu LI, Mărghitaș LA, Dezmirean D, Bobiș O, Mihai C, Pavel C. Physico-chemical composition of apilarnil (bee drone larvae). Lucrări Științifice. 2013;59:199-202. [Link] 
  42. Balkanska R, Karadjova I, Ignatova M. Comparative analyses of chemical composition of royal jelly and drone brood. Bulgarian Chemical Communications. 2014;46(2):412-6. [Link] 
  43. Isidorov VA, Bakier S, Stocki M. GC-MS Investigation of the chemical composition of honeybee drone and queen larva homogenate. J of Apiculturel Sci. 2016;60(1):111-20. [Crossref] 
  44. Mărgăoan R, Mǎrghitaş L, Dezmirean D, Bobiș O, Bonta V, Cătană C, et al. Comparative study on quality parameters of royal jelly, apilarnil and queen bee larvae triturate. Biology. 2017;74(1):51. [Crossref] 
  45. Silici S. Chemical content and bioactive properties of drone larvae (Apilarnil). Mellifera. 2019;19(2):14-22. [Link] 
  46. Sidor E, Miłek M, Zaguła G, Bocian A, Dżugan M. Searching for differences in chemical composition and biological activity of crude drone brood and royal jelly useful for their authentication. Foods. 2021;10(9):2233. [Crossref]  [PubMed]  [PMC] 
  47. Borkovcová M, Mlček J, Adámková A, Adámek M, Bednářová M, Musilová Z, et al. Use of foods based on bee drone brood: Their sensory and microbiological evaluation and mineral composition. Sustainability. 2022;14(5):2814. [Crossref] 
  48. Schneider E, Rolli-Derkinderen M, Arock M, Dy M. Trends in histamine research: new functions during immune responses and hematopoiesis. Trends Immunol. 2002;23(5):255-63. [Crossref]  [PubMed] 
  49. Mao X, Zeng X, Qiao S, Wu G, Li D. Specific roles of threonine in intestinal mucosal integrity and barrier function. Front Biosci (Elite Ed). 2011;3(4):1192-200. [Crossref]  [PubMed] 
  50. Lazaryan DS. Comparative amino acid analysis of bee brood. Pharmaceutical Chemistry Journal. 2002;36(12):680-2. [Crossref] 
  51. Ghosh S, Jung C, Meyer-Rochow VB. Nutritional value and chemical composition of larvae, pupae, and adults of worker honey bee, Apis mellifera ligustica as a sustainable food source. Journal of Asia-Pacific Entomology. 2016;19(2):487-95. [Crossref] 
  52. Ghosh S, Sohn HY, Pyo SJ, Jensen AB, Meyer-Rochow VB, Jung C. Nutritional Composition of Apis mellifera Drones from Korea and Denmark as a Potential Sustainable Alternative Food Source: Comparison Between Developmental Stages. Foods. 2020;9(4):389. [Crossref]  [PubMed]  [PMC] 
  53. Mandla R, Kumar NR. Comparison of carbohydrates in the worker, drone and queen brood food of Apis mellifera during spring. J Glob Biosci. 2016;5(3):3765-8. [Link] 
  54. Lipiński Z, Żółtowska K, Wawrowska J, Zaleska M. The concentration of carbohydrates in the developmental stages of the Apis mellifera carnica drone brood. J Apic Sci. 2008;52(1):5-11. [Link] 
  55. Erdem S, İnci H. Apilarnilin yağ asidi özelliklerinin belirlenmesi [Determination of fatty acid properties of apilarnil]. Türk Tarım ve Doğa Bilimleri Dergisi. 2022;9(4):900-6. [Crossref] 
  56. Choi JS. Nutrition, safety, health functional effects, and availability of honeybee (Apis mellifera L.) Drone Pupae. Insects. 2021;12(9):771. [Crossref]  [PubMed]  [PMC] 
  57. Aurori CM, Giurgiu AI, Conlon BH, Kastally C, Dezmirean DS, Routtu J, et al. Juvenile hormone pathway in honey bee larvae: a source of possible signal molecules for the reproductive behavior of Varroa destructor. Ecol Evol. 2020;11(2):1057-68. [Crossref]  [PubMed]  [PMC] 
  58. Erdem B, Özkök A. Can food supplement produced from apilarnil be an alternative to testosterone replacement therapy. Hacettepe Journal of Biology and Chemistry. 2017;4(45):635-8. [Crossref] 
  59. Seres A. Sexual hormone effects of honeybee (Apis mellifera) drone milk in male and female rats [Ph.D. thesis]. Szeged: University of Szeged; 2014. (Cited: 07.07.2023).Available from: [Link] 
  60. Burimistrova L. Physico-chemical and biological appreciation of drone brood [Ph.D. thesis]. Russia: Ryazan Medical University; 1999. p.159. Available from: [Link] 
  61. Trifonov VN, Elistratova JA, Elistratov KG, Kurus NV. Patent application publication. Pub. No: US 2014/0323.014 A1. United States, Patent Application Publication. 2014. Available from: [Link] 
  62. Shoinbayeva KB, Omirzak T, Bigara T, Abubakirova A, Aauylbay A. Biologically active preparation and reproductive function of stud rams. Asian Journal of Pharmaceutics. 2017;11(03):184-91. [Crossref] 

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7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com