Journal of Literature Pharmacy Sciences

Sıcaklığa Duyarlı Lipozomların Kanser Tedavisinde Kullanımları
Uses of Thermosensitive Liposomes in Cancer Treatment
Tahir Emre YALÇINa
aGazi Üniversitesi Eczacılık Fakültesi, Farmasötik Teknoloji ABD, Ankara, TÜRKİYE
J Lit Pharm Sci. 2020;9(3):285-91
doi: 10.5336/pharmsci.2020-75806
Article Language: TR
Full Text
ÖZET
 Kanser, insanlar için en tehlikeli hastalıklardan biridir ve her yıl milyonlarca ölüme neden olmaktadır. Kanser tedavisi için cerrahi, kemoterapi, radyoterapi, immünoterapi, hormon tedavisi ve bu yöntemlerin kombinasyonlarını içeren çeşitli stratejiler geliştirilmiştir. Günümüzde nanotaşıyıcılar, kanserin tanı ve tedavisine yönelik en yeni yaklaşımlardır. Lipozomlar, miseller, polimerik nanopartiküller, nanojeller ve dendrimerler gibi nano boyuttaki ilaç taşıyıcı sistemler, kanser tedavisindeki başarıyı artırmaktadır. Bu ilaç taşıyıcı sistemler arasında kanser tedavisi için lipozomlara olan ilgi giderek artmaktadır. Kanser tedavisinde kanserli hücrelere zarar verirken sağlıklı hücrelerin etkilenmemesi çok önemlidir. Salımı uyarıcılarla tetiklenen lipozomal sistemler bu ihtiyacı karşılama potansiyeline sahiptir. Uyarıcılar, yüklenmiş ilaçların hastalıklı dokulara salınmasında önemli bir rol oynamaktadır. Işık, pH ve yüksek sıcaklık hedefe özgü uyarıcılardır. Sıcaklığa duyarlı lipozomlar, tümöre hedeflenmiş kemoterapide önemli bir araştırma alanıdır. Bölgesel vücut sıcaklığı artırımı ile sıcaklığa duyarlı lipozomların beraber kullanılması, tümör içerisindeki ilaç konsantrasyonunu artırır. Böylece ilacın antitümör etkinliği artarken yan etkiler azalır.

Anahtar Kelimeler: Lipozomlar; tedavi edici hipertermi; ilaç tedavisi
ABSTRACT
 Cancer is one of the most dangerous diseases for humans and causes millions of death every year. Various strategies including surgery, chemotherapy, radiotherapy, immunotherapy, hormone therapy, and combinations of these methods have been developed for cancer treatment. Nowadays, nanocarriers have been the latest approaches for the diagnosis and treatment of cancer. Nanoscale drug delivery systems such as liposomes, micelles, polymeric nanoparticles, nanogels, and dendrimers increase success in cancer treatment. Amongst these drug delivery systems, there has been a growing interest of liposomes for cancer treatment. It is very important for cancer treatment that healthy cells are not affected while destroying cancer cells. Trigger release liposome systems hold potential to meet this need. The triggers play a key role in releasing the encapsulated drug into the diseased tissues. The target-specific triggers are light, pH, and hyperthermia. Thermosensitive liposomes have been an important research area in the field of tumor targeted chemotherapy. The combination of increasing local body temperature and thermosensitive liposomes results in increased intratumoral drug concentrations. Thus improve the antitumor efficacy of drugs and reduce side effects.

Keywords: Liposomes; therapeutic hyperthermia; drug therapy
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-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

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Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

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Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

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